A5105878279- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Health Systems, Economic Evaluations, Quality of Life
- Muscle and Compartmental Disorders
- Chronic Kidney Disease and Diabetes
- Hemodynamic Monitoring and Therapy
- Renal function and acid-base balance
- Body Composition Measurement Techniques
- Acute Kidney Injury Research
- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Climate Change and Health Impacts
- Organ Donation and Transplantation
- Potassium and Related Disorders
- Poverty, Education, and Child Welfare
- Healthcare cost, quality, practices
- Palliative Care and End-of-Life Issues
- Heart Failure Treatment and Management
- Neurological and metabolic disorders
- Healthcare Policy and Management
- Renal and Vascular Pathologies
- Gender, Labor, and Family Dynamics
- Therapeutic Uses of Natural Elements
- Nutrition and Health in Aging
- Iron Metabolism and Disorders
Keele University
2016-2025
University Hospitals of North Midlands NHS Trust
2015-2024
SKiN Health
2024
Takeda (United States)
2020-2024
Royal Stoke University Hospital
2010-2023
University of Sheffield
2022
Cliniques Universitaires Saint-Luc
2021
Amsterdam UMC Location University of Amsterdam
2021
University of Amsterdam
2021
RELX Group (United States)
2018-2020
ABSTRACT. The European APD Outcome Study (EAPOS) is a 2-yr, prospective, multicenter study of the feasibility and clinical outcomes automated peritoneal dialysis (APD) in anuric patients. A total 177 patients were enrolled with median age 54 yr (range, 21 to 91 yr). Previous time on was 38 mo 1.6 259 mo), 36% had previously been hemodialysis for >90 d. Diabetes cardiovascular disease present 17% 46% patients, respectively. prescription adjusted at physician discretion aim creatinine...
Globally, the number of patients undergoing maintenance dialysis is increasing, yet throughout world there significant variability in practice initiating dialysis. Factors such as availability resources, reasons for starting dialysis, timing initiation, patient education and preparedness, modality access, well varied "country-specific" factors significantly affect experiences outcomes. As burden end-stage kidney disease (ESKD) has increased globally, also been a growing recognition...
Lay summary The International Society for Peritoneal Dialysis last published a guideline on prescribing peritoneal dialysis (PD) in 2006. This focused clearance of toxins and used measure waste product removal by using urea as an example. suggested that specific quantity small solute was needed to achieve `adequacy'. It is now generally accepted, however, the well-being person related many different factors not just toxins. has been written with focus doing PD. proposed delivery should be...
Blood pressure (BP) and volume control are critical components of dialysis care have substantial impacts on patient symptoms, quality life, cardiovascular complications. Yet, developing consensus best practices for BP been challenging, given the absence objective measures extracellular status lack high-quality evidence many therapeutic interventions. In February 2019, Kidney Disease: Improving Global Outcomes (KDIGO) held a Controversies Conference titled Pressure Volume Management in...
The global nephrology community recognizes the need for a cohesive strategy to address growing problem of end-stage kidney disease (ESKD). In March 2018, International Society Nephrology hosted summit on integrated ESKD care, including 92 individuals from around globe with diverse expertise and professional backgrounds. attendees were 41 countries, 16 participants 11 low- lower-middle-income countries. purpose was develop strategic plan improve worldwide access by identifying prioritizing...
Home dialysis modalities (home hemodialysis [HD] and peritoneal [PD]) are associated with greater patient autonomy treatment satisfaction compared in-center modalities, yet the level of home-dialysis use worldwide is low. Reasons for limited utilization context-dependent, informed by local resources, costs, access to healthcare, health system policies, provider bias or preferences, cultural beliefs, individual lifestyle concerns, potential care-partner time, financial burdens. In May 2021,...
Abstract. Peritoneal solute transport increases with time on treatment in a proportion of peritoneal dialysis (PD) patients, contributing to ultrafiltration failure. Continuous exposure the peritoneum hypertonic glucose solutions results morphologic damage that may have causative role changes function. The purpose this analysis was establish whether increased preceded selected group long-term PD patients. transport, residual renal function, peritonitis rate, and were recorded prospectively...
Background. Comorbidity is the single most important determinant of outcome in patients on renal replacement therapy. The aims this study were to evaluate a semi‐quantitative approach comorbidity scoring predicting survival commencing peritoneal dialysis (PD), and establish interaction between other known predictors patient outcome, particular membrane function, residual function (RRF) plasma albumin. Methods. was recorded prospective, centre cohort 303 PD. Using seven disease domains,...
Peritoneal infection and poor ultrafiltration continue to be the major causes of treatment failure in CAPD. The combined effects peritonitis continuous exposure dialysis fluid remain most likely candidates affecting peritoneum long term. purpose this study was observe on longitudinal peritoneal function.The equilibration test (PET) utilized quantify changes low-molecular-weight solute transfer (D/P(creat)) (UF) 233 patients treated with Of these, 166 represented an unselected cohort (Group...
ABSTRACT. Worsening fluid balance results in reduced technique and patient survival peritoneal dialysis. Under these conditions, the glucose polymer icodextrin is known to enhance ultrafiltration long dwell. A multicenter, randomized, double-blind, controlled trial was undertaken compare versus 2.27% establish whether improves status. Fifty patients with urine output <750 ml/d, high solute transport, either treated hypertension or untreated BP >140/90 mmHg, a requirement for equivalent of...
BACKGROUND: Loss of residual renal function has a profound effect on the survival peritoneal dialysis patients. Less is known impact function. The purpose this study was to investigate influence solute transport clinical outcome in CAPD METHODS: Two hundred and ten consecutive patients commencing since 1990 were enrolled into single centre prospective longitudinal observational urea, protein, kinetics. On entry, at 6-monthly intervals, estimations made weight, body mass index (BMI), plasma...
Systemic inflammation, as evidenced by elevated inflammatory cytokines, is a feature of advanced renal failure and predicts worse survival. Dialysate IL-6 concentrations associate with variability in peritoneal small solute transport rate (PSTR), which has also been linked to patient Here, we determined the link between systemic intraperitoneal inflammation regards membrane function survival part Global Fluid Study, multinational, multicenter, prospective, combined incident prevalent cohort...
♦Extending technique survival on peritoneal dialysis (PD) remains a major challenge in optimizing outcomes for PD patients while increasing utilization. The primary objective of the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) is to identify modifiable practices associated with improvements patient survival. In collaboration International Society (ISPD), PDOPPS seeks standardize PD-related data definitions provide forum effective international collaborative clinical...
Human blood Vγ9/Vδ2 T cells, monocytes and neutrophils share a responsiveness toward inflammatory chemokines are rapidly recruited to sites of infection. Studying their interaction in vitro relating these findings vivo observations patients may therefore provide crucial insight into events. Our present data demonstrate that cells potent survival signals resulting neutrophil activation the release chemoattractant CXCL8 (IL-8). In turn, readily respond harboring phagocytosed bacteria, as...
A pathophysiological taxonomy: classification of membrane dysfunction, which provides mechanistic links to functional characteristics, should be used when prescribing individualized dialysis or planning modality transfer (e.g. automated peritoneal (PD) haemodialysis) in the context shared and informed decision-making with person on PD, taking individual circumstances treatment goals into account. (practice point).Identification fast solute rate (PSTR): It is recommended that PSTR determined...
Over a three-year period, 217 episodes of bacterial peritonitis occurred in 183 patient years. Thirty-seven were due to Staphylococcus aureus and 19 (51%) these required removal the catheter eradicate infection. This compared with loss 4/63 (6.3%) coagulase negative staphylococci infections (p less than 0.001); 7/67 (9.5%) culture 10/30 (33.3%) gram-negative organisms 0.05). half (51.3%) S. associated exit-site infections, this rose 100% (10/10) recurrent 0.01). A prospective analysis nasal...
"Epidemiology: Study Design and Data Analysis." Journal of the American Statistical Association, 101(473), pp. 404–405
Peritoneal dialysis (PD) patients may be overhydrated especially when inflammation is present. We hypothesized that with a plasma albumin below the median value would have measurable overhydration without proportional increase in volume (PV).We investigated cross-sectional sample of 46 prevalent PD powered to detect PV associated whole body and hypoalbuminemia. was determined from (125)I-labeled dilution, absolute total water D dilution (TBW(D)), relative hydration multifrequency...