A5043964486- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Kidney Stones and Urolithiasis Treatments
- Biomedical Research and Pathophysiology
- Pediatric Urology and Nephrology Studies
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- CAR-T cell therapy research
- Biomedical Ethics and Regulation
- COVID-19 Clinical Research Studies
- Psychosomatic Disorders and Their Treatments
- Immunotherapy and Immune Responses
- Family Caregiving in Mental Illness
- Methemoglobinemia and Tumor Lysis Syndrome
- Organ and Tissue Transplantation Research
- Neonatal Health and Biochemistry
- Renal Diseases and Glomerulopathies
- Ureteral procedures and complications
- Urological Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Mental Health Treatment and Access
- Healthcare cost, quality, practices
- Modernist Literature and Criticism
- Metabolism and Genetic Disorders
Guy's Hospital
2006-2024
Guy's and St Thomas' NHS Foundation Trust
2013-2024
St Thomas' Hospital
2015-2023
Chelsea and Westminster Hospital
2020
Park University
2020
Seattle University
2020
Microsoft (Brazil)
2020
Lister Hospital
2019
King's College London
2005-2011
Imperial College Healthcare NHS Trust
2009
BackgroundIndividuals with rare kidney diseases account for 5–10% of people chronic disease, but constitute more than 25% patients receiving replacement therapy. The National Registry Rare Kidney Diseases (RaDaR) gathers longitudinal data from these conditions, which we used to study disease progression and outcomes death failure.MethodsPeople aged 0–96 years living 28 types were recruited 108 UK renal care facilities. primary cumulative incidence mortality failure in individuals diseases,...
The concept of regulatory T cell (Treg)-based immunotherapy has enormous potential for facilitating tolerance in autoimmunity and transplantation. Clinical translation Treg therapy requires production processes that satisfy the rigors Good Manufacturing Practice (GMP) standards. In this regard, we report our findings on implementation a robust GMP compliant process ex vivo expansion clinical grade Tregs, demonstrating feasibility developed manufacture final product application. This...
Short-term outcomes in kidney transplantation are marred by progressive transplant failure and mortality secondary to immunosuppression toxicity. Immune modulation with autologous polyclonal regulatory T cell (Treg) therapy may facilitate reduction promoting better long-term clinical outcomes. In a Phase I trial, 12 recipients received 1–10 × 106 Treg per kg at Day +5 posttransplantation lieu of induction (Treg Therapy cohort). Nineteen patients standard (Reference Primary were...
We and others have previously described signatures of tolerance in kidney transplantation showing the differential expression B cell–related genes relative expansions cell subsets. However, all these studies, index group—namely, tolerant recipients—were not receiving immunosuppression (IS) treatment, unlike rest comparator groups. aimed to assess confounding effect regimens develop a novel IS-independent signature tolerance. Analyzing gene three independent transplant patient cohorts (232...
Introduction Psychological distress is common in end-stage kidney disease (ESKD) and associated with poorer health outcomes. Cognitive behavioural therapy (CBT) recommended UK clinical guidelines for the management of depression people long-term conditions. Access to skilled therapists competent managing competing mental physical demands ESKD limited. Online CBT treatments tailored needs population offers a pragmatic solution under-resourced services. This study examines feasibility...
The risk of COVID-19 infection in transplant recipients (TRs) is unknown. Patients on dialysis may be exposed to greater due an inability isolate. Consideration these competing risks important before restarting suspended programs. This study compared outcomes kidney and kidney/pancreas TRs with those the waiting list, following admission a high-prevalence region.Audit data from all 6 London centers were amalgamated. Demographic laboratory collected included mortality, intensive care (ITU)...
There is accumulating evidence that cell surface molecules may be transferred between cells during an encounter. The aim of these experiments was to determine whether transfer allogeneic material T could influence human alloresponses. CD4(+) were cocultured with M1 (human fibroblast) transfectants expressing HLA-DR1, CD80 and CD86 alone or in combination. Up 95% the became positive for HLA-DR appropriate costimulatory after only 4 h coculture. phenomenon required contact membrane fluidity...
Immunosuppressive drugs are essential for the prevention of acute transplant rejection but some may not promote long-term tolerance. Tolerance is dependent on presence and regulatory function CD4+CD25+ T cells in a number animal models. The direct effects immunosuppressive cells, particularly those that interfere with IL-2 signaling uncertain. We studied rapamycin derivative everolimus anti-CD25 monoclonal antibody basiliximab capacity human vitro. Both permitted suppression proliferation...
Background. There are no clear guidelines on renal transplantation in patients with antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis. Methods. We undertook a survey of transplant centres across Europe to assess whether there was consensus about how manage then identified 107 allograft recipients whose primary disease systemic vasculitis and assessed their outcome post-transplant. Results. All questionnaire respondents felt that should be remission at transplantation, 16%...
CD4(+)CD25(+) and CD1d-restricted natural killer T (NKT) cells are thymus-derived self-reactive regulatory that play a key role in the control of pathological immune responses. Little is known about functional cooperation between innate NKT adaptive cells. Here we show human CD4(+)Valpha24(+)Vbeta11(+) (CD4(+) NKT) isolated from peripheral blood by flow cytometric cell sorting secrete substantial amounts IL-2 after stimulation with dendritic (DC) alpha-Galactosylceramide. When cocultured...
Harnessing naturally arising CD4+ CD25+ regulatory T cells (Tregs) for potential adoptive cell therapy is hampered by their innate autoreactivity and limited number.CD4+ Tregs were purified from peripheral blood of human leukocyte antigen (HLA) DR1*0101+ A2- individuals, stimulated with autologous monocyte-derived dendritic (DCs).Here we show that specific an HLA A2 (103-120) peptide can be selected the population a healthy individual detected using tetramer comprised DRB1*0101 peptide. The...
CD4(+)CD25(+) regulatory T cells have been shown to regulate a variety of autoimmune and allogeneic responses in mice humans. The role regulating alloresponses human transplant recipients remains uncertain. Previous research has demonstrated reduced frequency direct pathway donor-specific renal when compared with the reactive an HLA-matched third party. A number mechanisms proposed account for this finding; purpose study was determine whether play significant role. Twelve stable patients...
To estimate the proportion of psychiatric inpatients receiving primary interventions based on randomised controlled trials or systematic reviews trials.Retrospective survey.Acute adult general ward.All patients admitted to ward during a 28 day period.Primary were classified according whether not they supported by evidence from reviews.The received 26/40 (65%; 95% confidence interval (95% CI) 51% 79%) period reviews.When used as denominator, most given in acute psychiatry experimental...
Higher blood pressures (mean systolic difference 16.8 mmHg) when compared to matched individuals are already reported in patients with calcium urolithiasis. We present the prevalence of hypertension and renal impairment cystinuria from our specialist single centre. analysed prospective database adult who attend service. This included details medical operative management their disease. Descriptive statistics were used analyse data. 120 a median age 40 (19–76) years, 66 male (55%) 54 female...
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and carries a fatality rate of 1.0% to 13.5% in confirmed cases.1Verity R. Okell L.C. Ddorigatti I. et al Estimates the severity 2019: model-based analysis.Lancet Infect Dis. 2020; 20: 669-677Abstract Full Text PDF PubMed Scopus (2298) Google Scholar,2Johns Hopkins University Center for Systems Science Engineering (JHU CSSE)COVID-19 Data Repository (CSSE) at Johns...
Kidney transplant recipients (KTRs) with "operational tolerance" (OT) maintain a functioning graft without immunosuppressive (IS) drugs, thus avoiding treatment complications. Nevertheless, IS drugs can influence gene-expression signatures aiming to identify OT among treated KTRs.