A5063061981- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Dialysis and Renal Disease Management
- Renal and Vascular Pathologies
- Pancreatic function and diabetes
- Muscle and Compartmental Disorders
- Abdominal vascular conditions and treatments
- Transplantation: Methods and Outcomes
- Adrenal and Paraganglionic Tumors
- Liver Disease and Transplantation
- Pituitary Gland Disorders and Treatments
- Ocular Surface and Contact Lens
- Pain Mechanisms and Treatments
- Pancreatic and Hepatic Oncology Research
- Renal Diseases and Glomerulopathies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Parathyroid Disorders and Treatments
- Diabetes and associated disorders
- Abdominal Surgery and Complications
- Hormonal Regulation and Hypertension
- Intestinal and Peritoneal Adhesions
- Organ and Tissue Transplantation Research
- Electronic Health Records Systems
- Genetic Syndromes and Imprinting
Mayo Clinic in Arizona
2025
Manchester Royal Infirmary
2015-2024
Manchester University NHS Foundation Trust
2012-2024
Manchester Academic Health Science Centre
2017-2024
University of Manchester
2015-2024
Engineering and Physical Sciences Research Council
2024
NIHR Manchester Biomedical Research Centre
2023
The University of Texas Southwestern Medical Center
2017-2022
National Health Service
2004-2022
LMC Diabetes & Endocrinology (Canada)
2010-2021
Diabetic neuropathy is associated with increased morbidity and mortality. To date, limited data in subjects impaired glucose tolerance diabetes demonstrate nerve fiber repair after intervention. This may reflect a lack of efficacy the interventions but also difficulty tests currently deployed to adequately assess repair, particularly short-term studies. Corneal confocal microscopy (CCM) represents novel noninvasive means quantify damage repair. Fifteen type 1 diabetic patients undergoing...
Corneal confocal microscopy (CCM) is a rapid, noninvasive, clinical examination technique that quantifies small nerve fiber pathology. We have used it to assess the neurological benefits of pancreas transplantation in type 1 diabetic patients.In 20 patients with diabetes undergoing simultaneous and kidney (SPK) 15 control subjects, corneal sensitivity was evaluated using noncontact esthesiometry, morphology assessed CCM.Corneal (1.54 +/- 0.28 vs. 0.77 0.02, P < 0.0001), density (NFD) (13.8...
The study aimed to assess the impact on neuropathy of simultaneous pancreas and kidney transplantation (SPK) in individuals with type 1 diabetes. This longitudinal observational examined neuropathic symptoms, deficits, quantitative sensory testing, neurophysiology, corneal confocal microscopy skin biopsy results 32 healthy (non-diabetic) control participants, 29 diabetes severe diabetic peripheral [DPN] 36 after SPK. Following SPK, HbA1c, eGFR, triacylglycerols HDL improved significantly...
Prognostic risk prediction models aim to estimate the of a future outcome based on available clinical parameters.[1][1] There has been an increase in development such given move towards personalised and precision medicine, since they provide individualised risks for patients.[
No AccessJournal of UrologyAdult urology1 Jun 2007Impact Stents on Urological Complications and Health Care Expenditure in Renal Transplant Recipients: Results a Prospective, Randomized Clinical Trial A. Tavakoli, R.S. Surange, R.C. Pearson, N.R. Parrott, T. Augustine, H.N. Riad TavakoliA. Tavakoli , SurangeR.S. Surange PearsonR.C. Pearson ParrottN.R. Parrott AugustineT. Augustine RiadH.N. View All Author Informationhttps://doi.org/10.1016/j.juro.2007.01.152AboutFull TextPDF ToolsAdd to...
Pancreas transplantation in complicated type 1 (insulin dependent) diabetes mellitus improves the quality of life, increases longevity and stabilizes diabetic complications. There may be clinician reticence due to perceived poor outcomes with published associated mortality rates 5-8% significant co-morbidities, particularly cardiovascular impairment.Retrospective analysis was performed on patients undergoing pancreas a single centre since programme's initiation [simultaneous kidney (SPK) =...
Study Type - Therapy (case series).4. What's known on the subject? and What does study add? The indications timing of native nephrectomy in patients with autosomal dominant polycystic kidney disease (ADPKD) is controversial, especially for those undergoing renal transplantation. Post-transplant unilateral appears to be preferred intervention compared pre-transplant nephrectomy. There seems substantial additive risk bilateral over nephrectomy, prior Pre-transplant should only carried out when...
Background. Transplant renal artery stenosis (TRAS) is a recognized complication resulting in post-transplant hypertension associated with allograft dysfunction. It commonly missed but potentially treatable that may present from months to years after transplant surgery. In this retrospective study, we compared management strategies and outcomes of TRAS 1990 2005. Methods. Case notes recipients demonstrated by angiography were reviewed. Angiography was carried out when there clinical or...
Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate long-term failure. Mismatches between donor and recipient HLA play an important role the acute chronic allogeneic immune response against graft. Perfect matching at clinically relevant loci does obviate need for immunosuppression, suggesting that additional genetic variation plays a critical both short- graft outcomes. By combining patient data samples from supranational...
Kidney and islet transplantation has revolutionized the management of renal failure diabetes. Transplantation is considered as excellent therapeutic intervention for most suitable patients. While advancements in surgical aspects, immunosuppression outcomes have potentially plateaued, new technologies developed which could enhance with benefits to patients clinical teams alike. The science nanotechnology big data are two such technologies, collectively paving way smarter solutions....
<h3>ABSTRACT</h3> COVID-19 is impacting provision of renal transplantation in the UK with a reduction clinical activity. Publicly available Renal Registry and NHS Blood Transplant reports were analysed to model number missed transplant opportunities, waiting list size change dialysis population over six-month period starting 5 March 2020. An estimated 1,670 kidney opportunities may be lost, which will lead 6,317 active patients on kidney-alone list, compared 4,649 based usual activity...
Pancreas transplantation (PT) remains the only treatment that can restore insulin independence among insulin-dependent diabetics. An ageing population in developed countries has led to an increasing number of older patients who may be suitable for PT. Some investigators argue PT recipients than 50 years inferior outcome compared with younger group.The object this study was compare outcomes 31 aged and above 105 below performed between June 2001 December 2007.The incidence general...
A 56-year-old female patient was referred to the transplant assessment clinic in July 2016. She started haemodialysis 2012 for renal failure due urinary tract infections. is doing very well on dialysis and has an excellent exercise tolerance without shortness of breath or angina. had no infections since starting other comorbidity, except well-controlled hypertension hyperparathyroidism requiring treatment with cinacalcet. Clinical examination essentially normal truncal obesity height 167 cm...
Kidneys from older donors are likely to have a lower nephron mass. Nevertheless they constitute valuable source of kidney allografts. Long cold ischemic time (CIT), with or without delayed graft function (DGF), has been associated reduced survival. The aim this study was review the experience single UK center assess interaction storage time, donor age, organ exchange, and HLA-DR mismatching on short- long-term survival.We analyzed 788 first cadaver transplants that were performed in our 1990...