A5040930081- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Pancreatic function and diabetes
- Transplantation: Methods and Outcomes
- Cytomegalovirus and herpesvirus research
- Organ Donation and Transplantation
- Neurological Complications and Syndromes
- Renal and Vascular Pathologies
- Diabetes and associated disorders
- Pregnancy and Medication Impact
- Organ and Tissue Transplantation Research
- Liver Disease and Transplantation
- Renal Diseases and Glomerulopathies
- Blood groups and transfusion
- T-cell and B-cell Immunology
- Pharmacological Effects and Toxicity Studies
- Oral and gingival health research
- SARS-CoV-2 and COVID-19 Research
- Viral-associated cancers and disorders
- Immunodeficiency and Autoimmune Disorders
- Polyomavirus and related diseases
- Xenotransplantation and immune response
- Complement system in diseases
- Immune Cell Function and Interaction
- Diabetes Treatment and Management
Institut de Transplantation Urologie en Nephrologie
2016-2025
Inserm
2013-2024
Centre Hospitalier Universitaire de Nantes
2013-2024
Center for Research in Transplantation and Translational Immunology
2019-2024
Nantes Université
2008-2024
Hotel Dieu Hospital
2005-2023
Centre d'Investigation Clinique de Nantes
1991-2022
Fondation Centaure
2021
Astellas Pharma (Japan)
2016
Azienda Ospedaliera Universitaria Pisana
2011-2012
The involvement of immunologic and nonimmunologic events in long-term kidney allograft failure is difficult to assess. development HLA antibodies after transplantation the witness ongoing reactivity against transplant, several studies have suggested that presence correlates with poor graft survival. However, they not discriminated between donor-specific (DS) non-specific (NDS) antibodies. A total 1229 recipients a graft, transplanted 1972 2002, who had over 5-yr period prospective annual...
Interleukin-2 is a major growth factor for activated T lymphocytes, and antibodies reacting with the Tac-chain component of interleukin-2 receptor can prevent allograft rejection in animals. Because Tac chains are expressed only on small fraction monoclonal against may offer more specific means immunosuppression than polyclonal antilymphocyte globulin prophylaxis graft rejection. Therefore, we compared immunosuppressive effect 33B3.1, rat antibody human chain, rabbit antithymocyte randomized...
Background. Corticosteroid-free maintenance immunosuppression after organ transplantation eliminates the well-known corticosteroid-related side effects and may help to improve long-term outcome. We investigated whether a corticosteroid-free tacrolimus (Tac)/mycophenolate mofetil (MMF) regimen, in combination with daclizumab (Dac) induction therapy, provides adequate renal transplantation. Methods. This 6-month, open-label, multicenter, parallel-group study involved 538 patients randomized...
Accurate diagnosis and grading of rejection other pathological processes are paramount importance to guide therapeutic interventions in patients with pancreas allograft dysfunction. A multi-disciplinary panel pathologists, surgeons nephrologists was convened for the purpose developing a consensus document delineating histopathological features transplant biopsies. Based on available published data collective experience, criteria acute cell-mediated (ACMR) were established. Three severity...
The first Banff proposal for the diagnosis of pancreas rejection (Am J Transplant 2008; 8: 237) dealt primarily with acute T-cell-mediated (ACMR), while only tentatively addressing issues pertaining to antibody-mediated (AMR). This document presents comprehensive guidelines AMR, proposed at 10th Conference on Allograft Pathology and refined by a broad-based multidisciplinary panel. Pancreatic AMR is best identified combination serological immunohistopathological findings consisting (i)...
Forty seven renal allografts performed over a period of 12 years in 43 recipients with chronic failure due to biopsy-proved focal glomerulosclerosis (FGS, 5.34% from 888 cadaveric transplantations) were reviewed. Recurrence the disease was suspected 14 grafts (29.8%) on basis immediate proteinuria, but recurrence FGS lesions demonstrated only 7 patients. The remaining patients had minimal-change nephropathy or mesangial hyperplasia. duration before transplantation clear predictive risk...
During a 9-year follow-up, 167 consecutive pancreas transplant recipients (152 simultaneous pancreas-kidney [SPK]) were followed for the detection of posttransplant anti-HLA antibodies. Forty patients (24%) developed antibodies, 26 (65%) had donor-specific antibodies (DSA; 61% anticlass 2) and 14 (35%) non-DSA (78.6% 1). More rejection episodes observed in with positive than without (42.5% vs. 11%; p = 0.001), highest incidence DSA (53.8%). severe rejections (according to rescue therapy)...
Background. Basiliximab is an interleukin-2 receptor (IL-2R; CD25) chimeric monoclonal antibody for immunoprophylaxis against acute rejection in renal transplantation. Its pharmacokinetics were characterized a multicenter open-label, prospective dose-escalation study to identify single-dose regimen providing IL-2R-saturating serum concentrations the critical first posttransplant month. Methods. Thirty-two recipients of primary, mismatched cadaver kidneys enrolled: 20 men and 12 women, who...
A murine IgG1 monoclonal antibody, 25–3 (Immunotech, France), directed against the α chain (CD11a) of human LFA1 molecule was used in treatment 7 histologically documented first acute rejection kidney transplantations under cyclosporine. Four patients (group I) received 20 mg/day for 2 days and 10 8 MoAb. One developed Quincke's edema after injection immediately withdrawn from study. In patients, whose serum creatinine continued to increase, MoAb replaced by steroids, followed ALG 3 4...
Specific tolerance to LEW.1W (RT1U) heart allografts can be induced in adult LEW.1A (RT1a) rats by donorspecific blood transfusion (DST). We have previously shown that both rejected and tolerated grafts are heavily infiltrated T lymphocytes, cases these cells capable of developing similar cytotoxic responses against donor vitro; is therefore not due the deletion alloreactive cells. At same time, we found accumulation IL-2 IFN-γ mRNA was decreased compared with grafts. These results suggested...
Although combined pancreas and kidney transplantation is an established procedure for the treatment of type 1 diabetes (T1D) in patients with end-stage renal disease, role transplant alone (PTA) therapy T1D subjects preserved function still matter debate.We report our single-center experience PTA 71 consecutive all a posttransplant follow-up 5 years. Patient (normoglycemia absence any antidiabetic therapy) survivals were determined, several clinical parameters (including risk factors...
The rate of early pancreas allograft failure remains high due to thrombosis but also severity rejection episodes. We investigated if adjunct anti-TNFα therapy was safe and could improve outcomes after transplantation. all transplants performed in our institution between 2010 2022. Etanercept, an anti TNFα therapy, added standard immunosuppressive regimen since 2017 approval from institutional human ethics committee. Pancreas survival, episodes, as well infectious complications were analyzed....
Survival is the ultimate outcome measure in renal replacement therapy (RRT) and may be used to compare performance among centres. Such comparison, however, meaningless if influences of comorbidity, age early deaths are not considered. We therefore studied survival rates on RRT seven centres Europe after taking into account influence age, deaths, primary diagnoses, comorbidity.A retrospective analysis was carried out 1407 patients who commenced across five European countries during a 7-year...