Christophe Masset
A5055007301- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Transplantation: Methods and Outcomes
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- COVID-19 Impact on Reproduction
- Pancreatic function and diabetes
- Polyomavirus and related diseases
- Diabetes and associated disorders
- Organ Donation and Transplantation
- Parvovirus B19 Infection Studies
- Neurological Complications and Syndromes
- Vaccine Coverage and Hesitancy
- Long-Term Effects of COVID-19
- Liver Disease and Transplantation
- Immunodeficiency and Autoimmune Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Systemic Lupus Erythematosus Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood groups and transfusion
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Infective Endocarditis Diagnosis and Management
- Complement system in diseases
Institut de Transplantation Urologie en Nephrologie
2020-2025
Centre Hospitalier Universitaire de Nantes
2019-2024
Inserm
2019-2024
Nantes Université
2019-2024
Center for Research in Transplantation and Translational Immunology
2021-2024
Assistance Publique – Hôpitaux de Paris
2023
Centre d'Investigation Clinique de Nantes
2022
Laboratoire de Microbiologie et Génétique Moléculaires
2021
Hôtel-Dieu de Paris
2019
Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim this registry-based observational study was to explore characteristics outcomes transplants included French nationwide Registry Solid Organ Transplant Recipients with Covid-19. Covid-19 diagnosed symptomatic patients who had positive PCR assay for SARS-CoV-2 or having typical lung lesions imaging. Clinical...
There are no studies which have compared the risk of severe COVID-19 and related mortality between transplant recipients nontransplant patients. We enrolled two groups patients hospitalized for COVID-19, that is, kidney (KTR) from French Registry Solid Organ Transplant (n = 306) a single-center cohort 795). An analysis was performed among subgroups matched age factors or mortality. Severe defined as admission (or transfer) to an intensive care unit, need mechanical ventilation, death. were...
LettersMarch 2022Antibody Response to a Fourth Messenger RNA COVID-19 Vaccine Dose in Kidney Transplant Recipients: A Case SeriesFREESophie Caillard, MD, PhD, Olivier Thaunat, Ilies Benotmane, Christophe Masset, Gilles Blancho, PhDSophie PhDDepartment of Nephrology and Transplantation, University Hospitals Strasbourg, INSERM Unit 1109, France, Transplantation Clinical Immunology, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, 1111, MDDepartment MDInstitut Urologie Néphrologie,...
It remains unclear whether physicians should accept transplantation offers for candidates with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test due to the potential risk of severe infection after initiating immunosuppressive therapy. A multicenter observational study was conducted in 19 French solid organ units. Patients on waiting list liver or kidney transplants who had nasopharyngeal swab at time were recorded. Sixty-five patients included. The recipients...
Kidney transplant recipients (KTRs) are prone to develop severe COVID-19 and less well protected by vaccine than immunocompetent subjects. Thus, the use of neutralizing anti-SARS-CoV-2 monoclonal antibody (MoAb) confer a passive immunity appears attractive in KTRs.We performed French nationwide study compare COVID-19-related hospitalization, 30-day admission intensive care unit (ICU), death between KTRs who received an early infusion MoAb (MoAb group) did not (control group). Controls were...
The rate of early pancreas allograft failure remains high due to thrombosis but also severity rejection episodes. We investigated if adjunct anti-TNFα therapy was safe and could improve outcomes after transplantation. all transplants performed in our institution between 2010 2022. Etanercept, an anti TNFα therapy, added standard immunosuppressive regimen since 2017 approval from institutional human ethics committee. Pancreas survival, episodes, as well infectious complications were analyzed....
The mechanisms regulating CD8
Decreased immunosuppression has been proposed for kidney transplant recipients infected with coronavirus disease 2019 (COVID-19), but the impact on alloreactive immune response during and after infection poorly investigated. We evaluated occurrence of antihuman leukocyte antigen (HLA) donor-specific antibodies (DSAs) (post-COVID-19) rejection episodes COVID-19 particular focus modulation.Kidney from 2 French institutions had anti-HLA antibody screening before COVID-19. Management...
Background About 10–20% of pancreas allografts are still lost in the early postoperative period despite identification numerous detrimental risk factors that correlate with graft thrombosis. Methods We conducted a multicenter study including 899 transplant recipients between 2000 and 2018. Early failure due to complete thrombosis, long-term pancreas, kidney patient survivals were analyzed adjusted donor, recipient perioperative variables using multivariate cause-specific Cox model stratified...
Background. The clinical standard for pancreas preservation transplantation is static cold storage (SCS). Oxygenation during has been shown to be advantageous in studies. This study evaluates the efficiency of different oxygenation modalities hypothermic preservation. Methods. Thirty-two porcine pancreases were procured a controlled donation after circulatory death model and divided preserved 8 groups: (1) SCS, (2) machine perfusion (HMP), (3) oxygenated (HOPE) with 21% oxygen, (4) HOPE...
In nonimmunized patients, similar rejection rates are observed for patients who have undergone thymoglobulin (antithymocyte globulins [ATG]) or basiliximab (BSX) therapy. While ATG may improve delayed graft function, it also be associated with higher infection and malignancy risk. We compared survival clinical outcomes in elderly recipients low immunological risk according to their induction therapy.We conducted a multicentric study on ≥65 years of age receiving first kidney transplant...