Rutger J. Ploeg
A5037152123- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Renal and Vascular Pathologies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Neurological Complications and Syndromes
- Tissue Engineering and Regenerative Medicine
- Clinical Nutrition and Gastroenterology
- Cardiac Ischemia and Reperfusion
- SARS-CoV-2 detection and testing
- Anesthesia and Neurotoxicity Research
- Metabolism and Genetic Disorders
- Mesenchymal stem cell research
- Pancreatic function and diabetes
- Pancreatitis Pathology and Treatment
- Acute Kidney Injury Research
- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Dialysis and Renal Disease Management
- Pancreatic and Hepatic Oncology Research
- Hernia repair and management
University of Oxford
2016-2025
Leiden University Medical Center
2019-2025
University Medical Center Groningen
2013-2024
Oxford Health NHS Foundation Trust
2022-2024
Oxford BioMedica (United Kingdom)
2015-2024
Nuffield Orthopaedic Centre
2013-2024
John Radcliffe Hospital
2013-2024
Churchill Hospital
2013-2024
Oxford University Hospitals NHS Trust
2015-2024
Science Oxford
2024
In a retrospective analysis on 323 orthotopic liver transplant procedures performed between July 1984 and October 1991 the incidence of two forms primary dysfunction (PDF) liver: nonfunction (PNF), initial poor function (IPF) were studied. The PDF was 22% (73/323) with 6% PNF (20/323) 16% IPF (53/323), while 78% (250/323) had immediate (IF). Occurrence both resulted in higher graft failure rate (P < 0.001), retransplantation patient mortality 0.003) within first three months after OLTx....
Static cold storage is generally used to preserve kidney allografts from deceased donors. Hypothermic machine perfusion may improve outcomes after transplantation, but few sufficiently powered prospective studies have addressed this possibility.In international randomized, controlled trial, we randomly assigned one 336 consecutive donors and the other storage. All 672 recipients were followed for 1 year. The primary end point was delayed graft function (requiring dialysis in first week...
<h2>Summary</h2><h3>Background</h3> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic in 2020. Testing is crucial for mitigating public health and economic effects. Serology considered key to population-level surveillance potentially individual-level risk assessment. However, immunoassay performance not been compared on large, identical sample sets. We aimed investigate the of four high-throughput commercial SARS-CoV-2 antibody immunoassays novel...
In Brief Objective: Hypothermic machine perfusion may improve outcome after transplantation of kidneys donated cardiac death (DCD), but no sufficiently powered prospective studies have been reported. Because organ shortage has led to an increased use DCD kidneys, we aimed compare hypothermic with the current standard static cold storage preservation. Methods: Eighty-two kidney pairs from consecutive, controlled donors 16 years or older were included in this randomized trial Eurotransplant....
<ns3:p><ns3:bold>Background:</ns3:bold> The COVID-19 pandemic caused >1 million infections during January-March 2020. There is an urgent need for reliable antibody detection approaches to support diagnosis, vaccine development, safe release of individuals from quarantine, and population lock-down exit strategies. We set out evaluate the performance ELISA lateral flow immunoassay (LFIA) devices.</ns3:p><ns3:p> <ns3:bold>Methods:</ns3:bold> tested plasma COVID (severe acute respiratory...
ABSTRACT Background The COVID-19 pandemic caused >1 million infections during January-March 2020. There is an urgent need for reliable antibody detection approaches to support diagnosis, vaccine development, safe release of individuals from quarantine, and population lock-down exit strategies. We set out evaluate the performance ELISA lateral flow immunoassay (LFIA) devices. Methods tested plasma COVID (SARS-CoV-2) IgM IgG antibodies by using nine different LFIA used a panel samples who...
The survival of microencapsulated islet grafts is limited, even if capsular overgrowth restricted to a small percentage the capsules. In search processes other than contributing graft failure, we have studied islets in non-overgrown capsules at several time points after allotransplantation rat. All recipients allografts became normoglycemic. Grafts were retrieved 4 and 8 weeks implantation 15.3 +/- 2.3 postimplant, 2 mean period which failure occurred. Overgrowth was complete within it...
Abstract Background The initial treatment of acute necrotizing pancreatitis is conservative. Intervention indicated in patients with (suspected) infected pancreatitis. In the Netherlands, standard intervention necrosectomy by laparotomy followed continuous postoperative lavage (CPL). recent years several minimally invasive strategies have been introduced. So far, these never compared a randomised controlled trial. PANTER study (PAncreatitis, Necrosectomy versus sTEp up appRoach) was...
Hydrogen sulfide (H2S) is an endogenous gasotransmitter with physiologic functions similar to nitric oxide and carbon monoxide. Exogenous treatment H2S can induce a reversible hypometabolic state, which protect organs from ischemia/reperfusion injury, but whether cystathionine γ-lyase (CSE), produces H2S, has protective effects unknown. Here, human renal tissue revealed abundant expression of CSE, localized glomeruli the tubulointerstitium. Compared wild-type mice, CSE knockout mice had...
PLOEG, R. J.; GOOSSENS, D.; MCANULTY, J. F.; SOUTHARD, H.; BELZER, F. O. Author Information
Unexpected donation after cardiac death (DCD) donors suffer arrest suddenly and are maintained with normothermic extracorporeal membrane oxygenation (NECMO) while consent for is obtained. The objective of this study was to determine whether ex vivo machine perfusion (NMP) improves upon the benefits NECMO in a large-animal model unexpected DCD liver transplant.Donor pigs underwent 90-minute were divided 3 groups. In first, livers preserved immediately cold storage (CS, n = 6). other 2 groups,...
Vascular renal resistance (RR) during hypothermic machine perfusion (HMP) is frequently used in kidney graft quality assessment. However, the association between RR and outcome has never been prospectively validated. Prospectively collected values of 302 machine-perfused deceased donor kidneys all types (standard extended criteria donated after cardiac death), transplanted without prior knowledge these values, were studied. In this cohort, we determined delayed function (DGF) 1-year...