Ben J.�M. Witteman
A5045406391- Pancreatitis Pathology and Treatment
- Gastrointestinal motility and disorders
- Pancreatic and Hepatic Oncology Research
- Microscopic Colitis
- Inflammatory Bowel Disease
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Nutrition and Health in Aging
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Intestinal Malrotation and Obstruction Disorders
- Nutritional Studies and Diet
- Colorectal Cancer Screening and Detection
- Eosinophilic Esophagitis
- Glutathione Transferases and Polymorphisms
- Esophageal and GI Pathology
- Clinical Nutrition and Gastroenterology
- Growth Hormone and Insulin-like Growth Factors
- Clostridium difficile and Clostridium perfringens research
- Genomics, phytochemicals, and oxidative stress
- Infant Health and Development
Ziekenhuis Gelderse Vallei
2016-2025
Wageningen University & Research
2009-2025
Cambridge University Press
2023
New York University Press
2023
Bipar
2021
University Gastroenterology
2015
Hôpital Saint-Antoine
2011
Sorbonne Université
2011
Centre Léon Bérard
2011
GGD Rotterdam-Rijnmond
2009
Extensive population-based studies are much needed to accurately establish epidemiology and disease course in patients with primary sclerosing cholangitis (PSC). We aimed obtain prevalence incidence figures, insight regard survival, liver transplantation (LT), occurrence of malignancies, as well risk factors thereof. Four independent hospital databases were searched 44 hospitals a large geographically defined area the Netherlands, comprising 50% population. In addition, all PSC three Dutch...
Early enteral feeding through a nasoenteric tube is often used in patients with severe acute pancreatitis to prevent gut-derived infections, but evidence support this strategy limited. We conducted multicenter, randomized trial comparing early an oral diet at 72 hours after presentation the emergency department pancreatitis.
Primary sclerosing cholangitis (PSC) is strongly associated with inflammatory bowel disease (IBD). The aim of this study was to assess the IBD phenotype PSC in a large well-phenotyped population-based cohort using endoscopic and histopathologic criteria.PSC cases were identified ascertained, fulfilling well-established criteria, 39 hospitals geographically defined region Netherlands. location recorded according Montreal Classification. As classification does not consider segmental...
<h3>Importance</h3> For patients with painful chronic pancreatitis, surgical treatment is postponed until medical and endoscopic have failed. Observational studies suggested that earlier surgery could mitigate disease progression, providing better pain control preserving pancreatic function. <h3>Objective</h3> To determine whether early more effective than the endoscopy-first approach in terms of clinical outcomes. <h3>Design, Setting, Participants</h3> The ESCAPE trial was an unblinded,...
Infected necrotizing pancreatitis is a potentially lethal disease that treated with the use of step-up approach, catheter drainage often delayed until infected necrosis encapsulated. Whether outcomes could be improved by earlier unknown.
Abstract Background The initial treatment of acute necrotizing pancreatitis is conservative. Intervention indicated in patients with (suspected) infected pancreatitis. In the Netherlands, standard intervention necrosectomy by laparotomy followed continuous postoperative lavage (CPL). recent years several minimally invasive strategies have been introduced. So far, these never compared a randomised controlled trial. PANTER study (PAncreatitis, Necrosectomy versus sTEp up appRoach) was...
The recent addition of immunoglobulin (Ig)G4-associated cholangitis (IAC), also called IgG4-related sclerosing (IRSC), to the spectrum chronic cholangiopathies has created clinical need for reliable methods discriminate between IAC and more common cholestatic entities, primary (PSC) secondary cholangitis. current American Association Study Liver Diseases practice guidelines PSC advise on measurement specific Ig (sIg)G4 in patients, but interpretation elevated sIgG4 levels remains unclear. We...
In Brief Objectives: To determine the relation between intestinal barrier dysfunction, bacterial translocation, and clinical outcome in patients with predicted severe acute pancreatitis influence of probiotics on these processes. Summary Background data: Randomized, placebo-controlled, multicenter trial probiotic prophylaxis (Ecologic 641) (PROPATRIA). Methods: Excretion fatty acid binding protein (IFABP, a parameter for enterocyte damage), recovery polyethylene glycols (PEGs, permeability),...
Infected necrotising pancreatitis is a potentially lethal disease that nearly always requires intervention. Traditionally, primary open necrosectomy has been the treatment of choice. In recent years, surgical step-up approach, consisting percutaneous catheter drainage followed, if necessary, by (minimally invasive) become standard care. A promising minimally invasive alternative endoscopic transluminal approach. This approach consists necrosectomy. We hypothesise less superior to in terms...
The inflammatory bowel disease (IBD) is a chronic lifelong inflammation that may affect the entire gastro-intestinal tract in Crohn's and colon ulcerative colitis (UC). Diet plays an important role IBD patients many of them follow strict diet restriction order to reduce complaints prolong remission intervals. aim this study was assess dietary beliefs, behaviour nutrition knowledge Dutch adults with enable considering patient's perspective on advice.
Abstract Background & Aims Large population‐based studies are much needed to accurately establish the epidemiology of primary biliary cirrhosis ( PBC ). We aimed collect all patients in a geographically defined area evaluate and examine possible association with smoking, age at menarche, first pregnancy number pregnancies. Methods All between 2000 2008 were identified Netherlands, comprising 50% Dutch population. Four independent hospital databases searched 44 hospitals. Medical records...
Previous randomized trials, including the Transluminal Endoscopic Step-Up Approach Versus Minimally Invasive Surgical in Patients With Infected Pancreatic Necrosis (TENSION) trial, demonstrated that endoscopic step-up approach might be preferred over surgical patients with infected necrotizing pancreatitis based on favorable short-term outcomes. We compared long-term clinical outcomes of both approaches after a period at least 5 years.In this follow-up study, we reevaluated all data 83 (of...