H.J. van Wijk
A5009749055- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Meat and Animal Product Quality
- SARS-CoV-2 and COVID-19 Research
- Wheat and Barley Genetics and Pathology
- Research Data Management Practices
- Genetic Associations and Epidemiology
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Animal Genetics and Reproduction
- Biomedical Text Mining and Ontologies
- Scientific Computing and Data Management
- Colorectal and Anal Carcinomas
- Inflammatory Bowel Disease
- Bioinformatics and Genomic Networks
- Advanced Proteomics Techniques and Applications
- Neurological Disorders and Treatments
- Hepatitis C virus research
- Genetic factors in colorectal cancer
- Animal Nutrition and Physiology
- Chronic Lymphocytic Leukemia Research
- Pregnancy and Medication Impact
- Gene expression and cancer classification
- Genetics, Bioinformatics, and Biomedical Research
- COVID-19 diagnosis using AI
Leiden University Medical Center
2005-2024
Wageningen University & Research
2006
Máxima Medisch Centrum
2006
Radboud University Nijmegen
2006
The COVID-19 pandemic has challenged healthcare systems and research worldwide. Data is collected all over the world needs to be integrated made available other researchers quickly. However, various heterogeneous information that are used in hospitals can result fragmentation of health data multiple 'silos' not interoperable for analysis. Consequently, clinical observations hospitalised patients prepared reused efficiently timely. There a need adapt management make observational patient...
Breeding goals in pigs are subject to change and directed much more toward retail carcass yield meat quality because of the high economic value these traits. The objective this study was estimate genetic parameters growth, carcass, Carcass components included ham loin weights as primal cuts, which were further dissected into boneless subprimal cuts. Meat traits pH, drip loss, purge, firmness, color marbling both loin. Phenotypic measurements collected on a commercial crossbred pig population...
A QTL study for carcass composition and meat quality traits was conducted on finisher pigs of a cross between synthetic Piétrain/Large White boar line commercial sow cross. The mapping population comprised 715 individuals evaluated total 30 related to growth fatness (4 traits), (11 (15 traits). Offspring 8 sires (n = 715) were used linkage analysis genotyped 73 microsatellite markers covering 14 chromosomal regions representing approximately 50% the pig genome. examined selected based...
Diagnostic services for tuberculosis (TB) are not sufficiently accessible in low-resource settings, where most cases occur, which was aggravated by the COVID-19 pandemic. Early diagnosis of pulmonary TB can reduce transmission. Current TB-diagnostics rely on detection Mycobacterium (Mtb) sputum requiring costly, time-consuming methods, and trained staff. In this study, quantitative lateral flow (LF) assays were used to measure levels seven host proteins sera from pre-COVID-19 patients...
We investigated efficient case-control association analysis using family data. The outcome of interest was coronary heart disease. employed existing and new methods that take into account the correlations among related individuals to obtain proper type I error rates. considered for autosomal single-nucleotide polymorphisms were: 1) generalized estimating equations-based methods, 2) variance-modified Cochran-Armitage (MCA) trend test incorporating kinship coefficients, 3) genotypic modified...
Abstract SARS-CoV2 infection results in a range of disease severities, but the underlying differential pathogenesis is still not completely understood. At presentation it remains difficult to estimate and predict severity, particular, identify individuals at greatest risk progression towards most severe disease-states. Here we used advanced models with circulating serum analytes as variables combination daily assessment severity using SCODA-score, only single time points also during course...
Our aim is to develop methods for identifying a (causal) variant or variants from dense panel of single-nucleotide polymorphisms (SNPs) that are genotyped on the evidence previous studies. Because large number SNPs in close proximity each other, magnitude linkage disequilibrium (LD) plays an important role. Namely, highly correlated may hamper standard such as multivariate logistic regression due multicolinearity between covariates. Sequences models with high dimension naturally raise...
Summary Porcine chromosome 4 harbours many quantitative trait loci (QTL) affecting meat quality, fatness and carcass composition traits, detected in resource pig populations previously. However, prior to selection commercial breeds, QTL identified an intercross between divergent breeds require confirmation, so that they can be segregated. Consequently, the objective of this study was validate several on porcine responsible for quality traits. The experimental population consisted 14...
In a previous study, QTL for carcass composition and meat quality were identified in commercial finisher cross. The main objective of the current study was to confirm fine map on SSC4 SSC11 by genotyping an increased number individuals markers analyze data using combined linkage disequilibrium analysis method. A modified version method excludes information from analysis, enabling comparison results based only or information. Nine additional paternal half-sib families genotyped 18 markers,...
We introduce an approximate model for linkage curves which accommodates the polygenic structure of complex diseases and accounts simultaneous action closely located genes. The is extended so that information on biological pathways can be integrated. Using data rheumatoid arthritis, we describe some many applications allows: it used to test residual in presence already established loci, derive a global linkage, relevance gene list terms help candidate prioritization by integration...
Marker density of a QTL region on pig chromosome 4 was increased. New microsatellites were identified by in silico mining BAC-end and genomic shotgun sequences. Among 8,784 sequences predicted within the region, 148 identified. In addition, 27,450 CA/TG repeats sequences, which 157 most likely located SSC4q. A selection 61 new mapped, together with previously mapped markers. The results showed that human-pig comparative map combination sequence resources provides an excellent source for...
Breeding for improved pork quality has been the focus of much research in recent years and some results have already put into practice. The realized genetic response to selection within lines generally limited, however, compared with responses obtained other traits. relatively limited progress caused by lack incentive producers from industry, clear definition quality, high costs collection estimates, consequently availability phenotypic measures. discovery HAL gene greatly helped elimination...
Abstract Background The COVID-19 pandemic has challenged healthcare systems and research worldwide. Data is collected all over the world needs to be integrated made available other researchers quickly. However, various heterogeneous information that are used in hospitals can result fragmentation of health data multiple ‘silos’ not interoperable for analysis. Consequently, clinical observations hospitalised patients prepared reused efficiently timely. There a need adapt management make...