Shohreh Azimi
A5025881305- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Immune responses and vaccinations
- Maternal and Perinatal Health Interventions
- Respiratory viral infections research
- Pregnancy-related medical research
- Preterm Birth and Chorioamnionitis
- Long-Term Effects of COVID-19
- COVID-19 Impact on Reproduction
- Parkinson's Disease Mechanisms and Treatments
- Mycobacterium research and diagnosis
- Nicotinic Acetylcholine Receptors Study
- Neuroinflammation and Neurodegeneration Mechanisms
- Respiratory Support and Mechanisms
- Influenza Virus Research Studies
- Bacillus and Francisella bacterial research
- HIV/AIDS Impact and Responses
- HIV/AIDS drug development and treatment
- Zoonotic diseases and public health
- Adolescent Sexual and Reproductive Health
- Tuberculosis Research and Epidemiology
- HIV, Drug Use, Sexual Risk
- Bacterial Infections and Vaccines
- Pediatric health and respiratory diseases
Leiden University Medical Center
2021-2024
Tehran University of Medical Sciences
2020-2021
Loyola University Medical Center
2021
Islamic Azad University, Karaj
2013-2020
Assistance Publique – Hôpitaux de Paris
2007-2014
Hôpital Saint-Louis
2007-2014
Islamic Azad University, Tehran
2013
Abstract Fractional dosing can be a cost-effective vaccination strategy to accelerate individual and herd immunity in pandemic. We assessed the immunogenicity safety of primary intradermal (ID) vaccination, with 1/5th dose compared standard intramuscular (IM) mRNA-1273 SARS-CoV-2 naïve persons. conducted an open-label, non-inferiority, randomized controlled trial Netherlands between June December 2021. One hundred fifty healthy participants, aged 18–30 years, were (1:1:1) receive either two...
Whether nicotine has therapeutic effects on Parkinson's disease (PD) symptoms is controversial, but high doses and chronic treatment have never been tested. We report the results of a pilot, open‐label trial to assess safety possible efficacy nicotine. Six patients with advanced idiopathic PD received increasing daily transdermal up 105 mg/day over 17 weeks. All one accepted target dose. Nausea vomiting were frequent moderate, occurred in most (four six) who 90 14 weeks treatment. During...
The innate immune system plays a pivotal role in pathogen defense via pattern recognition receptor sensing, initiating responses upon infection or vaccination. Understanding its functional capacity is crucial for deciphering correlates of vaccine efficacy and understanding to infection. In this study, we developed holistic approach study function, generating >3100 readouts across 16 cell types, 18 receptors 11 produced cytokines using spectral flow cytometry. To explore geographical...
The objectives of this study were to analyze the clinical features and laboratory profiles risk factors associated with critical illness children severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).One hundred sixty-six disease 2019 (COVID-19) Iranian pediatric patients recruited through a collaborative research network between March May 2020. Demographics, clinical, laboratory, radiological results obtained from patient files.Of 166 patients, 102 (61%) 64 (39%) males females,...
Cellular metabolism is a key determinant of immune cell function. Here we found that CD14
Abstract The immune system plays a major role in Coronavirus Disease 2019 (COVID-19) pathogenesis, viral clearance and protection against re-infection. Immune cell dynamics during COVID-19 have been extensively documented peripheral blood, but remain elusive the respiratory tract. We performed minimally-invasive nasal curettage mass cytometry to characterize cells of patients 5-6 weeks after hospitalization. Contrary observations no general T depletion at mucosa could be detected. Instead,...
Introduction: To date, little is known about the clinical features of pediatric COVID-19 patients admitted to intensive care units (ICUs). Objective: Herein, we aimed describe differences in demographic characteristics, laboratory findings, presentations, and outcomes Iranian ICU versus those non-ICU settings. Methods: This multicenter investigation involved 15 general pediatrics hospitals included cases with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...
Pneumocystis jirovecii pneumonia (PCP) remains a leading cause of mortality among HIV-infected patients. The aim study was to find out P. in versatile group HIV-positive patients prisoners.Overall, 102 HIV positive from Ghezel Hesar Prison, Karaj, Iran October 2016 March 2017 without any respiratory symptoms were selected with different medication histories against and PCP. Microscopic molecular (qualitative real-time PCR) examination applied on sputum specimens serological investigation...
The introduction of polymerase chain reaction (PCR) techniques has improved the detection respiratory viruses, particularly with use multiplex real-time technique capability simultaneous various pathogens in a single reaction. aim this study was to apply above technology for diagnosis influenza infections and at same time differentiate between common flu species hospitalized patients Laleh hospital (Iran) two seasons (2016- 2017 2017-2018). Different specimens were collected from 540 period...
Abstract Background: The objectives of this study were to analyze the clinical features and laboratory profiles risk factors associated with critical illness children SARS-CoV-2. Methods: 325 COVID-19 pediatric patients recruited through a collaborative research network between March May 2020. Demographics, clinical, laboratory, radiological results obtained from patient files. Results: Of patients, 189 (58%) 136 (42%) males females, respectively. mean age was 6.18 ± 4.99. 195 (60%) 130...
Increased nasopharyngeal carriage of pathogenic bacteria is found in low socioeconomic status (SES) settings. How SES affects local immune responses, important for controlling colonization, currently unknown.Examining bacterial colonization and cytokine response the nasal mucosa children from high SES.Nasosorption samples were collected October 2019 48 50 schoolchildren, a cross-sectional study Makassar, Indonesia. Twenty-five cytokines measured fluid. Quantitative polymerase chain reaction...
Abstract BACKGROUND Nasopharyngeal carriage of pathogenic bacteria precedes invasive disease and higher rates are found in low socioeconomic-status (SES) settings. Local immune responses important for controlling colonization, but whether SES affects these is currently unknown. OBJECTIVE Examining bacterial colonization cytokine response nasal mucosa children from high SES. METHODS Twenty-five cytokines were measured fluid. qPCR was performed to determine density Haemophilus influenzae (H....
Abstract Background: To date, less is known about the clinical features of COVID-19 pediatric patients admitting to ICUs. Herein, we aimed describe differences in demographic characteristics, laboratory findings, presentations, and outcomes between ICU non-ICU settings. Methods: This multicenter study involved 15 general pediatrics hospitals on confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by positive real-time reverse transcription polymerase chain...