A5034102311- Parasites and Host Interactions
- Immune responses and vaccinations
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Research on Leishmaniasis Studies
- Long-Term Effects of COVID-19
- T-cell and B-cell Immunology
- Dietary Effects on Health
- COVID-19 Impact on Reproduction
- COVID-19 epidemiological studies
- Reproductive System and Pregnancy
- Parasitic Diseases Research and Treatment
- Zoonotic diseases and public health
- Vitamin K Research Studies
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Mosquito-borne diseases and control
- Cytomegalovirus and herpesvirus research
- Diverse Scientific Research Studies
Leiden University Medical Center
2016-2024
Loyola University Medical Center
2021
Mass cytometry identifies clusters of type 2 and regulatory immune responses in pre– post–anthelmintic treatment human blood samples.
Schistosomiasis affects over 250 million people, predominantly in Sub-Saharan Africa. In Schistosoma-endemic regions a lack of natural sterilizing immunity means individual are repeatedly infected, treated and reinfected. Due to difficulties tracking infection endemic areas, the kinetics host immune response during these reinfections have not been elucidated. Here, we use repeated (3x) controlled human Schistosoma mansoni (Sm) (repeated CHI) directly study how antigen-specific T cells...
Schistosomiasis is an infection caused by contact with
B-cells play a critical role in the formation of immune responses against pathogens by acting as antigen-presenting cells, modulating and generating memory antibody responses. Here, we studied B-cell subset distributions between regions with higher lower microbial exposure, i.e. comparing peripheral blood from people living Indonesia or Ghana to those healthy Dutch residents using 36-marker mass cytometry panel. By applying an unbiased multidimensional approach, observed differences balance...
Abstract The immune system plays a major role in Coronavirus Disease 2019 (COVID-19) pathogenesis, viral clearance and protection against re-infection. Immune cell dynamics during COVID-19 have been extensively documented peripheral blood, but remain elusive the respiratory tract. We performed minimally-invasive nasal curettage mass cytometry to characterize cells of patients 5-6 weeks after hospitalization. Contrary observations no general T depletion at mucosa could be detected. Instead,...
Abstract Hookworm infection remains a significant public health concern, particularly in low- and middle-income countries, where mass drug administration has not stopped reinfection. Developing vaccine is crucial to complement current control measures, which necessitates thorough understanding of host immune responses. By leveraging controlled human models high-dimensional immunophenotyping, here we investigated the remodeling following with 50 Necator americanus L3 hookworm larvae four...
Abstract Schistosomiasis is a prevalent helminthiasis, affecting over 230 million people worldwide, with varied, stage specific morbidity. Whilst the Th2 and regulatory immune responses in chronic infection have been relatively well studied, we little understanding of human during acute infection. This despite initial infective stages being proposed as crucial targets for much-needed vaccine development. Here, comprehensively map male female single-sex controlled Schistosoma mansoni Using...
Abstract BACKGROUND Vaccinations against infectious diseases save millions of lives, however reduced vaccine responses have been observed in low-income settings. Therefore, understanding differences immune profiles populations with high or low socioeconomic status (SES) is importance for optimizing efficacy. AIM Examining the profile children versus SES city Makassar, Indonesia. METHODS Using mass cytometry, we profiled cells finger-prick blood samples attending and schools RESULTS Distinct...