A5050907541- Rheumatoid Arthritis Research and Therapies
- Retinal Diseases and Treatments
- Muscle Physiology and Disorders
- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Adipose Tissue and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Bioinformatics and Genomic Networks
- Statistical Methods and Bayesian Inference
- Gene expression and cancer classification
- Parasites and Host Interactions
- Lymphoma Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Statistical Methods and Inference
- Advanced Causal Inference Techniques
- HER2/EGFR in Cancer Research
- Congenital heart defects research
- SARS-CoV-2 and COVID-19 Research
- Statistical Methods in Clinical Trials
- Retinal Development and Disorders
- Bone Tumor Diagnosis and Treatments
- Parasite Biology and Host Interactions
- Single-cell and spatial transcriptomics
Leiden University Medical Center
2015-2024
Leiden University
2015-2018
Centraal Bureau voor de Statistiek
2015
Loyola University Medical Center
2013
KU Leuven
2006-2009
<h3>Background</h3> A prolonged symptom or disease duration at treatment initiation is associated with unfavourable outcomes in rheumatoid arthritis (RA). It unknown whether this relation linear, referring to a common 'the-earlier-the-better principle', transient time frame which the more susceptible exists, 'window of opportunity'. To elucidate this, we evaluated shape associations persistence RA. <h3>Methods</h3> Patients 1987 RA treated modifying antirheumatic drugs (DMARDs) Leiden Early...
The logistic transformation, originally suggested by Johnson (1949), is applied to analyze responses that are restricted a finite interval (e.g. (0,1)), so-called bounded outcome scores. Bounded scores often have non-standard distribution, e.g. J- or U-shaped, precluding classical parametric statistical approaches for analysis. Applying the transformation on normally distributed random variable, gives rise logit-normal (LN) distribution. This distribution can take variety of shapes (0,1)....
Objective Fatigue is prevalent and disabling in rheumatoid arthritis (RA). Surprisingly, the long-term course of fatigue studied seldom it unclear to what extent influenced by inflammation. This study aimed determine during 8 years follow-up, its association with severity inflammation effect improved treatment strategies. Methods 626 patients RA included Leiden Early Arthritis Clinic cohort were years. severity, measured on a 0–100 mm scale, other clinical variables assessed yearly. Patients...
Significance Chronic helminth infections are accompanied by profound immune regulation. In humans, helminth-induced reactivity has not been thoroughly investigated in trial settings. We assessed the effect of anthelmintic treatment on responses a whole community placebo-controlled randomized controlled trial. show increased to helminth-specific as well unrelated antigens, parallel with decreased expression cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), which is molecule involved...
To study neo-aortic growth and the evolution of valve regurgitation (AR) in patients with transposition great arteries (TGA) after arterial switch operation (ASO) from newborn to adulthood identify at risk.Neo-aortic dimensions (annulus/root/sinotubular junction) were assessed serially 345 TGA who underwent ASO between 1977 2015. Linear mixed-effect models used assess increase over time risk factors for dilatation. Risk factor analysis AR by using time-dependent Cox regression models.After a...
<b>Tele-monitoring during the COVID-19 pandemic is recognised as a safe strategy to monitor patients at home. This first controlled study that demonstrates effectiveness of home monitoring reduce hospital admissions 28-day follow-up.</b>https://bit.ly/39vvngH
Aims The optimal method of tibial component fixation remains uncertain in total knee arthroplasty (TKA). Hydroxyapatite coatings have been applied to improve bone ingrowth uncemented designs, but may only coat the directly accessible surface. As peri-apatite (PA) is solution deposited, this increase coverage implant surface and thereby fixation. We assessed PA-coated TKAs versus cemented TKAs. Patients Methods were randomised or In 60 patients (30 each group), radiostereometric analysis...
Abstract Background Analysis of muscle biopsies allowed to characterize the pathophysiological changes Duchenne and Becker muscular dystrophies (D/BMD) leading clinical phenotype. Muscle tissue is often investigated during interventional dose finding studies show in situ proof concept pharmacodynamics effect tested drug. Less invasive readouts are needed objectively monitor patients' health status, quality, response treatment. The identification serum biomarkers correlating with function...
To assess whether chronic central serous chorioretinopathy (cCSC) patients without a complete resolution of subretinal fluid (SRF) after either half-dose photodynamic therapy (PDT) or high-density subthreshold micropulse laser (HSML) treatment may benefit from crossover treatment.Multicenter prospective interventional case series.cCSC with persistent SRF at the final visit PLACE trial were included. Patients received PDT HSML.Thirty-two and 10 HSML. At first evaluation (6-8 weeks treatment),...
Longitudinal studies often generate incomplete response patterns according to a missing not at random mechanism. Shared parameter models provide an appealing framework for the joint modelling of measurement and missingness processes, especially in nonmonotone case, assume set effects induce interdependence. Parametric assumptions are typically made distribution, violation which leads model misspecification with potential effect on estimates standard errors. In this article we avoid any...
Background Helminth infections are proposed to have immunomodulatory activities affecting health outcomes either detrimentally or beneficially. We evaluated the effects of albendazole treatment, every three months for 21 months, on STH, malarial parasitemia and allergy. Methods Findings A household-based cluster-randomized, double-blind, placebo-controlled trial was conducted in an area Indonesia endemic STH. Using computer-aided block randomization, 481 households (2022 subjects) 473 (1982...
The severity of joint destruction is highly variable between rheumatoid arthritis (RA) patients. majority its heritability still unexplained. Several autoimmune diseases share genetic risk variants that may also influence disease progression. We aimed to identify factors for the damage in RA by studying susceptibility loci several diseases.
Abstract Background Duchenne muscular dystrophy (DMD) is a fatal disease for which no cure available. Clinical trials have shown to be largely underpowered due inter‐individual variability and noisy outcome measures. The availability of biomarkers able anticipate clinical benefit highly needed improve trial design facilitate drug development. Methods In this study, we aimed appraise the value protein predict prognosis monitor progression or treatment in patients affected by DMD. We collected...
Background Preventive chemotherapy with praziquantel (PZQ) is the cornerstone of schistosomiasis control. However, a single dose PZQ (40 mg/kg) does not cure all infections. Repeated doses at short intervals might increase efficacy in terms rate (CR) and intensity reduction (IRR). Here, we determined versus four repeated treatments on Schistosoma mansoni infection school-aged children from Côte d'Ivoire, using two different diagnostic tests. Methods An open-label, randomized controlled trial...
Abstract Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling are postulated to favor a pathological pulmonary endothelial cell (EC) phenotype in arterial hypertension (PAH). BMP9 is shown reinstate BMP receptor type-II (BMPR2) levels thereby mitigate hemodynamic vascular abnormalities several animal models of (PH). Yet, responses the endothelium PAH patients unknown. Therefore, we treated primary patient-derived healthy ECs with observed that...
Abstract Purpose To describe the treatment outcomes and recurrence risk of chronic central serous chorioretinopathy (cCSC) in patients who had complete resolution subretinal fluid (SRF) after either primary half‐dose photodynamic therapy (PDT) or high‐density subthreshold micropulse laser (HSML) PLACE trial. Methods This multicentre prospective follow‐up study evaluated cCSC at 1 year completion Outcomes included: SRF on OCT, best‐corrected visual acuity (BCVA) Early Treatment Diabetic...
Purpose: A retrospective study was performed with data from the prospective randomized controlled trials, PLACE and SPECTRA, assessing risk of foveal atrophy likelihood structural functional improvement on optical coherence tomography, after half-dose photodynamic therapy in chronic central serous chorioretinopathy. Methods: total 57 chorioretinopathy patients received a single treatment spot that included fovea. Optical tomography scans fundus autofluorescence images were analyzed for...
Abstract Background The multicentre randomised SPARC trial evaluated the efficacy of a nurse-led sexual rehabilitation intervention on functioning, distress, dilator use, and vaginal symptoms after radiotherapy for gynaecological cancers. Methods Eligible women were to or care-as-usual. Four sessions scheduled over 12 months, with concurrent validated questionnaires clinical assessments. Primary outcome was Female Sexual Function Index (FSFI). A generalised-mixed-effects model compared...
Abstract Muscular dystrophies are characterized by a progressive loss of muscle tissue and/or function. While metabolic alterations have been described in patients’‐derived biopsies, non‐invasive readouts able to describe these needed order objectively monitor condition and response treatment targeting abnormalities. We used metabolomic approach study metabolites concentration serum patients affected multiple forms muscular dystrophy such as Duchenne Becker dystrophies, limb‐girdle type 2A...