Jonathan W. Uzorka
A5047500175- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- Parasitic Infections and Diagnostics
- Toxoplasma gondii Research Studies
- Antimicrobial Resistance in Staphylococcus
- Diagnosis and treatment of tuberculosis
- vaccines and immunoinformatics approaches
Leiden University Medical Center
2017-2024
Leiden University
2017-2019
Background Screening for tuberculosis (TB) infection often includes QuantiFERON-TB Gold Plus (QFT) testing. Previous studies showed that two-thirds of patients with negative QFT results just below the cut-off, so-called borderline test results, nevertheless had other evidence TB infection. This study aimed to identify a biomarker profile by which due can be distinguished from random variation. Methods supernatants (≥0.15 and <0.35 IU·mL −1 ), low-negative (<0.15 ) or positive (≥0.35...
QuantiFERON (QFT) results near the cut-off are subject to debate. We aimed investigate which borderline QFT were due Mycobacterium tuberculosis (Mtb)-specific responses or test variability.In a contact investigation, tuberculin skin (TST), and T-SPOT.TB (T-SPOT) performed in 785 BCG-unvaccinated contacts. Contacts with low-negative (<0.15), (0.15-0.35), low-positive (0.35-0.70) high-positive (≥0.70 IU/mL) compared respect exposure, TST T-SPOT results. Development of active was...
Abstract SARS-CoV2 infection results in a range of disease severities, but the underlying differential pathogenesis is still not completely understood. At presentation it remains difficult to estimate and predict severity, particular, identify individuals at greatest risk progression towards most severe disease-states. Here we used advanced models with circulating serum analytes as variables combination daily assessment severity using SCODA-score, only single time points also during course...
Several radiological features have been reported in association with latent tuberculosis infection (LTBI) but it has not studied which are specific. The aim of this study was to evaluate allegedly characteristic abnormalities on chest radiography (CXR) patients LTBI compared uninfected controls.From 236 tested QuantiFERON-TB Gold In-Tube (QFT), the CXR re-evaluated a blinded fashion for fibrotic scarring, (non-)calcified nodules and pleural thickening. defined as presence positive QFT result...
While postnatal toxoplasmosis in immune-competent patients is generally considered a self-limiting and mild illness, it has been associated with variety of more severe clinical manifestations. The causal relation some manifestations, e.g. myocarditis, microbiologically proven, but this not unequivocally so for other reported associations, such as epilepsy. We aimed to systematically assess causality between epilepsy patients. A literature search was performed. Bradford Hill criteria were...
Abstract Screening for latent tuberculosis infection (LTBI) is indicated before immunosuppressive therapies but complicated by lack of a gold standard and limited by, e.g., immunosuppression. This study aimed to investigate series patients diagnosed with LTBI during screening therapy, describing how the use diagnostic tests treatment evolved over time. retrospective cohort included all individuals intended therapy in tertiary care hospital between January 2000 December 2017. Evidence LTBI,...