A5024464547- Sepsis Diagnosis and Treatment
- Blood transfusion and management
- Traumatic Brain Injury and Neurovascular Disturbances
- Clinical Reasoning and Diagnostic Skills
- Hemodynamic Monitoring and Therapy
- Cerebral Palsy and Movement Disorders
- Long-Term Effects of COVID-19
- Hemoglobin structure and function
- Heart Rate Variability and Autonomic Control
- Influenza Virus Research Studies
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Viral gastroenteritis research and epidemiology
- Balance, Gait, and Falls Prevention
- Neonatal Health and Biochemistry
- Thermal Regulation in Medicine
- COVID-19 Clinical Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
- SARS-CoV-2 and COVID-19 Research
- Photodynamic Therapy Research Studies
- Respiratory viral infections research
- Effects of Vibration on Health
Leiden University Medical Center
2020-2024
Sanquin
2020-2024
Jon J van Rood Centre for Clinical Transfusion Research
2024
Radboud University Nijmegen
2016-2018
Radboud University Medical Center
2016-2018
Radboud Institute for Molecular Life Sciences
2018
We investigated the added predictive value of lactate and clearance to Acute Physiology Chronic Health Evaluation IV model for predicting in-hospital mortality in critically ill patients with sepsis.Retrospective observational cohort study.Mixed ICU Leiden University Medical Center, The Netherlands.Critically adult sepsis who have been admitted Netherlands, from 2006 January 2018.None.We fitted a baseline predictors 13 prespecified combinations at 0, 6 24 hours after admission create set...
Objectives Describing mitochondrial oxygenation (mitoPO 2 ) and its within- between-subject variability over time after 5-aminolevulinic acid (ALA) plaster application in healthy volunteers. Design Prospective cohort study. Setting Measurements were performed Leiden University Medical Center, the Netherlands. Participants Healthy volunteers enrolled from July to September 2020. Interventions Two ALA plasters placed parasternal left right, with a 3-hour interval, examine influence of calendar...
The Physiological Profile Assessment (PPA) is used in research and clinical practice for assessing fall risk. We compared PPA test performance between people with multiple sclerosis (MS) healthy controls, determined the fall-risk profile MS developed a reference database MS.For this study, 416 ambulant (51.5 ± 12.0 years) 352 controls (52.8 12.2 underwent (tests of contrast sensitivity, proprioception, quadriceps strength, reaction time sway) composite scores computed from these measures....
Abstract SARS-CoV2 infection results in a range of disease severities, but the underlying differential pathogenesis is still not completely understood. At presentation it remains difficult to estimate and predict severity, particular, identify individuals at greatest risk progression towards most severe disease-states. Here we used advanced models with circulating serum analytes as variables combination daily assessment severity using SCODA-score, only single time points also during course...
Abstract Purpose Currently, there is no marker of efficacy red blood cell (RBC) transfusion. This study describes the impact RBC transfusion on mitochondrial oxygen tension (mitoPO 2 ) and consumption (mitoVO in critically ill patients with anemia. Methods Critically a hemoglobin concentration < 10 g/dL, for whom single unit had been ordered, were included. MitoPO was measured COMET device immediately before transfusion, 0.5 h, 1 3 24 h after MitoVO calculated from dynamic mitoPO...
This is the first paper to simulate mitochondrial oxygen tension in skin circulatory shock. The relationships of mitoPo 2 with parameters (microcirculatory) delivery aid understanding noninvasive bedside measurement values and show that two orders magnitude higher than classically assumed. model can be used enhance clinical trial design investigating as a resuscitation target
Introduction The recently developed protoporphyrin IX-triple state lifetime technique measures mitochondrial oxygenation tension (mitoPO 2 ) in vivo at the bedside. MitoPO might be an early indicator of oxygen disbalance cells critically ill patients and therefore may support clinical decisions regarding red blood cell (RBC) transfusion. We aim to investigate effect RBC transfusion associated changes haemoglobin concentration on mitoPO other physiological tissue balance with anaemia. present...
We previously reported the added value of 24-hour lactate concentration alone and in combination with clearance at admission for prediction inhospital mortality critically ill patients sepsis. aimed to validate this finding.The derivation cohort from Leiden, The Netherlands, consisted 451 sepsis.The validation 4,440 adult sepsis Medical Information Mart Intensive Care admitted ICU Beth Israel Deaconness Center, Boston, MA, between January 2006 2018.Predictors were: age, chronic...
The influenza H1N1 pandemic of 2009-2010, provided a unique opportunity to assess the course disease, as well analysis risk factors for severe disease in hospitalized children (< 18 years).Retrospective national chart study on with infection during 2009-2010 pH1N1 outbreak.Nine hundred forty patients (56% boys), median age 3.0 years, were enrolled; majority previously healthy. Treatment consisted supplemental oxygen (24%), mechanical ventilation (5%) and antiviral therapy (63%). Fifteen died...