A5016971282- Birth, Development, and Health
- Urological Disorders and Treatments
- Pregnancy and preeclampsia studies
- Maternal Mental Health During Pregnancy and Postpartum
- Pesticide Exposure and Toxicity
- Pregnancy and Medication Impact
- Esophageal and GI Pathology
- Congenital Anomalies and Fetal Surgery
- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- Gestational Diabetes Research and Management
- Heavy Metal Exposure and Toxicity
- Congenital gastrointestinal and neural anomalies
- Sexual Differentiation and Disorders
- Spinal Dysraphism and Malformations
- Congenital Diaphragmatic Hernia Studies
- Cerebrospinal fluid and hydrocephalus
- Air Quality and Health Impacts
- Folate and B Vitamins Research
- Urinary and Genital Oncology Studies
- Prenatal Substance Exposure Effects
- Renal and related cancers
- Neonatal Respiratory Health Research
- Assisted Reproductive Technology and Twin Pregnancy
- Fetal and Pediatric Neurological Disorders
Radboud University Nijmegen
2015-2025
Radboud University Medical Center
2015-2025
University Medical Center
2012-2022
Radboud Institute for Molecular Life Sciences
2016-2022
National Institute for Health Research
2021
Bradford Teaching Hospitals NHS Foundation Trust
2021
Netherlands Organisation for Health Research and Development
2021
Amalia Kinderziekenhuis
2015-2019
Boston Children's Hospital
2015
Open Evidence
2014
The traditional epidemiologic modes of data collection, including paper-and-pencil questionnaires and interviews, have several limitations, such as decreasing response rates over the last decades high costs in large study populations. use Web-based may be an attractive alternative but is still scarce research because major concerns about selective nonresponse reliability obtained. authors discuss advantages disadvantages current developments this area. In addition, they focus on some...
Abstract Background During the past 25 years, many pregnancy and birth cohorts have been established. Each cohort provides unique opportunities for examining associations of early‐life exposures with child development health. However, to fully exploit large amount available resources facilitate cross‐cohort collaboration, it is necessary accessible information on each its individual characteristics. The aim this work was provide an overview European registered in a freely database located at...
Ataxia-telangiectasia (A-T) is an autosomal recessive neurodegenerative disorder with multisystem involvement and cancer predisposition, caused by mutations in the A-T mutated (ATM) gene. To study genotype–phenotype correlations, we evaluated clinical laboratory data of 51 genetically proven patients, additionally measured ATM protein expression kinase activity. Patients without activity showed classical phenotype. The presence protein, correlated slightly better immunological function....
Jeune asphyxiating thoracic dystrophy (JATD) is a rare, often lethal, recessively inherited chondrodysplasia characterised by shortened ribs and long bones, sometimes accompanied polydactyly, renal, liver retinal disease. Mutations in intraflagellar transport (IFT) genes cause JATD, including the IFT dynein-2 motor subunit gene DYNC2H1. Genetic heterogeneity large DYNC2H1 size have hindered JATD genetic diagnosis.To determine contribution to we screened 71 patients combining SNP mapping,...
Abstract Background Depression and anxiety during pregnancy are associated with adverse health outcomes for both mother child. This study aims to investigate the occurrence of symptoms depression in early late pregnancy, longitudinal changes from factors pregnant women Netherlands. Methods We studied 2897 participating PRegnancy Infant DEvelopment (PRIDE) Study. To assess anxiety, web‐based questionnaires including Hospital Anxiety Scale (HADS) multiple questions on maternal characteristics...
Gestational weight gain differs according to pre-pregnancy body mass index and is related the risks of adverse maternal child health outcomes. charts for women in different groups enable identification offspring at risk We aimed construct gestational reference underweight, normal weight, overweight, grades 1, 2 3 obese compare these with those obtained uncomplicated term pregnancies. used individual participant data from 218,216 pregnant participating 33 cohorts Europe, North America,...
Using a mobile app for self-management could make it easier patients to get insight into their blood pressure patterns. However, little is known about the availability, quality, and features of apps targeting pressure.The goal research was determine functionality, quality that be used monitoring purposes.A systematic search performed based on standards reviews. We searched Dutch official stores Android iOS platforms using predefined keywords included all English pressure. Two independent...
BACKGROUND: In 2002, an increased risk of hypospadias was reported for sons women exposed to diethylstilbestrol (DES) in utero, suggesting transgenerational effects DES. The aim this study further assess the association between parental DES exposure and a case–referent study. METHODS: Cases with were retrieved from hospital information system. Referents recruited via parents cases. Both completed postal questionnaires. Associations estimated by odds ratios (OR) 95% confidence intervals (CI)....
Nurses and other hospital workers are exposed to antineoplastic drugs during daily activities. Previous studies suggest that at occupational exposure levels may be toxic reproduction, but these not consistent or conclusive.Self-administered questionnaires were completed by 4393 nonexposed nurses employed between 1990 1997 (79% response). Questions asked about pregnancy outcome, work-related exposures, lifestyle. Exposure was estimated using task-based dermal measurements self-reported task...