A5076156434- Effects and risks of endocrine disrupting chemicals
- Nanoparticles: synthesis and applications
- Air Quality and Health Impacts
- Indoor Air Quality and Microbial Exposure
- Toxic Organic Pollutants Impact
- Nanoparticle-Based Drug Delivery
- Inhalation and Respiratory Drug Delivery
- Chemical Safety and Risk Management
- Contact Dermatitis and Allergies
- Carcinogens and Genotoxicity Assessment
- Odor and Emission Control Technologies
- Environmental Toxicology and Ecotoxicology
- Microplastics and Plastic Pollution
- Safety Warnings and Signage
- Advanced Nanomaterials in Catalysis
- Healthcare and Environmental Waste Management
- Environmental Justice and Health Disparities
- Animal testing and alternatives
- COVID-19 epidemiological studies
- Graphene and Nanomaterials Applications
- Infection Control and Ventilation
- Pesticide Exposure and Toxicity
- Protein Interaction Studies and Fluorescence Analysis
- Climate Change and Health Impacts
- Chemistry and Chemical Engineering
National Institute for Public Health and the Environment
2015-2024
Trinity College Dublin
2022
Nederlandse Internisten Vereniging
2012
The bisphenols S, F, and AF (BPS, BPF, BPAF) are used to replace the endocrine disrupting chemical bisphenol A (BPA) while exerting estrogenic effects of comparable potency. We assessed cumulative risk for aforementioned BPs in Europe compared before after year 2011, which was when first BPA restrictions became effective. For this, we probabilistically modeled external exposures from food, personal care products (PCPs), thermal paper, dust (using tools MCRA PACEM food PCPs, respectively)....
Abstract The European Green Deal outlines ambitions to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the Commission has published Chemicals Strategy for Sustainability: Towards Toxic‐Free Environment , which provides targets innovation better protect human environmental health, including challenges posed hazardous chemicals animal testing. project PATROLS (Physiologically Anchored Tools Realistic nanOmateriaL hazard aSsessment) addressed multiple...
In the risk assessment of chemical substances, aggregation exposure to a substance from different sources via pathways is not common practice. Focusing on single source can lead significant underestimation risk. To gain more insight how perform an aggregate assessment, we applied deterministic (tier 1) and person-oriented probabilistic approach 2) for four most parabens through personal care products in children between 0 3 years old. Following approach, worst-case estimate calculated...
Two small-scale field studies were conducted to investigate the transfer of substances from products into dust due direct and air-mediated transfer. The project focused on semivolatile organic compounds (SVOCs), which are frequently found in re-emitted dust. For studies, four artificial containing deuterium-labeled SVOCs (eight phthalates adipates) installed residential indoor environments. plastic vertically substance evaporation air. One product a carpet horizontally source A pyrethroid...
Semivolatile organic compounds (SVOCs) can be released from products and distributed in the indoor environment, including air dust. However, mechanisms extent of substance transfer into dust are not well understood. Therefore, a small-scale field study nine SVOCs was investigated: Four artificial consumer were doped with eight deuterium-labeled plasticizers (phthalates adipates) installed five homes to investigate emission processes evaporation, abrasion, direct transfer. Intentional release...
Abstract Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the size, shape, chemical composition and surface properties encapsulating nanoparticle, and, thus, less dependent on physicochemical active pharmaceutical ingredient encapsulated. In current work, we aimed to investigate impact formulation type biodistribution profile for two clinically relevant nanoformulations. We performed a comparative study in healthy rats at several dose levels durations up...
Traditionally, administered mass is used to describe doses of conventional chemical substances in toxicity studies. For deriving toxic nanomaterials, and composition alone may not adequately the dose, because particles with same can have completely different depending on properties such as particle size. Other dose metrics number, volume, or surface area been suggested, but consensus lacking. The discussion regarding most adequate metric for nanomaterials clearly needs a systematic, unbiased...
As personal care products (PCPs) are used in close contact with a person, they major source of consumer exposure to chemical substances contained these products. The estimation realistic PCPs is currently hampered by the lack appropriate data and methods. To estimate aggregate consumers PCPs, person-oriented model has been developed (the Probabilistic Aggregate Consumer Exposure Model, PACEM). simulates daily population based on product use collected from survey among Dutch population....
Background: SARS-CoV-2 can be effectively transmitted between individuals located in close proximity to each other for extended durations. Aircraft provide such conditions. Although high attack rates during flights were reported, little was known about the risk levels of aerosol transmission aircraft cabins. Objectives: The major objective estimate contracting COVID-19 from particles Methods: In two single-aisle and one twin-aisle aircraft, dispersion generated over a seven-row economy class...
Abstract Background Physiologically based kinetic models facilitate the safety assessment of inhaled engineered nanomaterials (ENMs). To develop these models, high quality datasets on well-characterized ENMs are needed. However, there at present, several data gaps in systemic availability poorly soluble particles after inhalation. The aim present study was therefore to acquire two comparable parametrize a physiologically-based model. Method Rats were exposed cerium dioxide (CeO 2 , 28.4 ±...
Abstract Physiologically‐based kinetic (PBK) modeling is a valuable tool to understand the kinetics of nanoparticles (NPs) in vivo. However, estimating PBK parameters remains challenging and commonly requires animal studies. To develop predictive models estimate parameter values based on NP characteristics, database containing corresponding characteristics needed. As first step toward this objective, study estimates for gold NPs (AuNPs) provides comparison two different NPs. Two experiments...
Assessing exposure to semivolatile organic compounds (SVOCs) that are emitted from consumer products and building materials in indoor environments is critical for reducing the associated health risks. Many modeling approaches have been developed SVOC assessment indoors, including DustEx webtool. However, applicability of these tools depends on availability model parameters such as gas-phase concentration at equilibrium with source material surface, y0, surface-air partition coefficient, Ks,...
The use of nanobiomaterials (NBMs) is becoming increasingly popular in the field medicine. To improve understanding on biodistribution NBMs, present study aimed to implement and parametrize a physiologically based pharmacokinetic (PBPK) model. This model was used describe two NBMs after intravenous administration rats, namely, poly(alkyl cyanoacrylate) (PACA) loaded with cabazitaxel (PACA-Cbz), LipImage™ 815. A Bayesian parameter estimation approach applied PBPK using data. Parametrization...