A5085834116- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Obsessive-Compulsive Spectrum Disorders
- Genetic Associations and Epidemiology
- Attention Deficit Hyperactivity Disorder
- Pelvic floor disorders treatments
- Parkinson's Disease Mechanisms and Treatments
- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- Mitochondrial Function and Pathology
- Eating Disorders and Behaviors
- Neuroendocrine regulation and behavior
- MicroRNA in disease regulation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Genomic variations and chromosomal abnormalities
- Memory and Neural Mechanisms
- Neurological diseases and metabolism
- Bladder and Urothelial Cancer Treatments
- CRISPR and Genetic Engineering
- Cancer-related gene regulation
- Inflammatory mediators and NSAID effects
- Genetic Neurodegenerative Diseases
- Genomics and Rare Diseases
- Animal Genetics and Reproduction
- ATP Synthase and ATPases Research
Radboud University Nijmegen
2016-2025
Radboud University Medical Center
2016-2025
University Medical Center
2019-2023
ING Direct
2023
UK Dementia Research Institute
2019
Radboud Institute for Molecular Life Sciences
2014-2018
Massachusetts General Hospital
2011-2016
Center for Human Genetics
2011-2016
Harvard University
2011-2016
Dutch Expert Centre for Screening
2016
The excitatory/inhibitory (E/I) imbalance hypothesis posits that between excitatory (glutamatergic) and inhibitory (GABAergic) mechanisms underlies the behavioral characteristics of autism. However, how E/I arises it may differ across autism symptomatology brain regions is not well understood. We used innovative analysis methods-combining competitive gene-set gene-expression profiles in relation to cortical thickness (CT) investigate relationships genetic variance, structure participants...
Autism spectrum disorders (ASDs) and autistic traits in the general population may share genetic susceptibility factors. In this study, we investigated such potential overlap based on common variants. We developed validated a self-report questionnaire of adults. then conducted genome-wide association studies (GWASs) six trait scores derived from through exploratory factor analysis 1981 adults population. Using results Psychiatric Genomics Consortium GWAS ASDs, observed sharing between ASDs...
Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) often co-occur. Both are highly heritable; however, it has been difficult to discover genetic risk variants. Glutamate GABA main excitatory inhibitory neurotransmitters in the brain; their balance is essential for proper brain development functioning. In this study we investigated role of glutamate genetics ADHD severity, symptom severity performance, based on gene set analysis, an approach investigate...
Abstract Parkinson’s disease is caused by a complex interplay of genetic and environmental factors. Although number independent molecular pathways processes have been associated with familial disease, common mechanism underlying especially sporadic still largely unknown. In order to gain further insight into the etiology we here conducted network literature analyses integrate top-ranked findings from thirteen published genome-wide association studies (involving 13.094 cases 47.148 controls)...
Abstract The core diagnostic criteria for autism comprise two symptom domains – social and communication difficulties, unusually repetitive restricted behaviour, interests activities. There is some evidence to suggest that these are dissociable, though this hypothesis has not yet been tested using molecular genetics. We test a genome-wide association study ( N = 51,564) of non-social trait related autism, systemising, defined as the drive analyse build systems. demonstrate systemising...
The prevalence of somatic insulinopathies, like metabolic syndrome (MetS), obesity, and type 2 diabetes mellitus (T2DM), is higher in Alzheimer's disease (AD), autism spectrum disorder (ASD), obsessive-compulsive (OCD). Dysregulation insulin signalling has been implicated these neuropsychiatric disorders, shared genetic factors might partly underlie this observed multimorbidity. We investigated the overlap between AD, ASD, OCD with MetS, T2DM by estimating pairwise global correlations using...
Type 2 diabetes mellitus (T2DM) is linked with several neurodegenerative and psychiatric disorders, either as a comorbid condition or risk factor. We aimed to expand the evidence by examining associations broad range of brain disorders (psychiatric neurological excluding late-onset disorders), while also accounting for temporal order T2DM these disorders.In population-based cohort-study 1,883,198 Danish citizens, born 1955-1984 followed until end 2016, we estimated between 16 first diagnosed...
Abstract The co-occurrence of insulin resistance (IR)-related metabolic conditions with neuropsychiatric disorders is a complex public health challenge. Evidence the genetic links between these phenotypes emerging, but little currently known about genomic regions and biological functions that are involved. To address this, we performed Local Analysis [co]Variant Association (LAVA) using large-scale (N=9,725-933,970) genome-wide association studies (GWASs) results for three IR-related (type 2...
Abstract Dyslexia is the most common childhood learning disorder and it a significantly heritable trait. At least nine chromosomal loci have been linked to dyslexia, additional susceptibility on other chromosomes suggested. Within two of these loci, DYX1C1 (15q21) ROBO1 (3p12) recently proposed as dyslexia candidate genes through molecular analysis translocation breakpoints in dyslexic individuals carrying balanced translocations. Moreover, genetic association studies indicated cluster five...
Autism spectrum disorders (ASDs) are highly heritable, and six genome-wide association studies (GWASs) of ASDs have been published to date. In this study, we integrated the findings from these GWASs with other genetic data identify enriched networks that associated ASDs. We conducted bioinformatics systematic literature analyses 200 top-ranked ASD candidate genes five GWASs. The sixth GWAS was used for replication validation our findings. Further corroborating evidence obtained through rare...
Levels of sociability are continuously distributed in the general population, and decreased represents an early manifestation several brain disorders. Here, we investigated genetic underpinnings population. We performed a genome-wide association study (GWAS) score based on four social functioning-related self-report questions from 342,461 adults UK Biobank. Subsequently gene-wide functional follow-up analyses. Robustness analyses were form GWAS split-half validation analyses, as well...
The co-occurrence of insulin resistance (IR)-related metabolic conditions with neuropsychiatric disorders is a major public health challenge. Evidence the genetic links between these phenotypes emerging, but little currently known about genomic regions and biological functions that are involved. To address this, we performed Local Analysis [co]Variant Association (LAVA) using large-scale (N = 9,725-933,970) genome-wide association studies (GWASs) results for three IR-related (type 2 diabetes...
Oppositional defiant disorder (ODD) is a frequent psychiatric seen in children and adolescents with attention‐deficit‐hyperactivity (ADHD). ODD also common antecedent to both affective disorders aggressive behaviors. Although the heritability of has been estimated be around 0.60, there little research into molecular genetics ODD. The present study examined association irritable defiant/vindictive dimensions categorical subtypes (based on latent class analyses) previously described specific...