A5080214074- Lung Cancer Treatments and Mutations
- Cardiac Imaging and Diagnostics
- Advanced Breast Cancer Therapies
- Cardiovascular Function and Risk Factors
- Lung Cancer Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Cardiovascular Health and Disease Prevention
- Ethics in Clinical Research
- PI3K/AKT/mTOR signaling in cancer
- Dialysis and Renal Disease Management
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Genetic Neurodegenerative Diseases
- Renal function and acid-base balance
- Mental Health and Patient Involvement
- Asthma and respiratory diseases
- Health Systems, Economic Evaluations, Quality of Life
- Pain Management and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Thermoregulation and physiological responses
- Heart Rate Variability and Autonomic Control
- Meta-analysis and systematic reviews
- Systemic Sclerosis and Related Diseases
- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
The University of Queensland
2020-2025
University of Dundee
2015-2024
University College Dublin
2022
Royal Brisbane and Women's Hospital
2021-2022
Bradford Teaching Hospitals NHS Foundation Trust
2020
University of Leeds
2020
Radboud University Medical Center
2019
Radboud University Nijmegen
2019
University of Glasgow
2019
Newcastle University
2019
There is considerable overlap between left ventricular noncompaction (LVNC) and other cardiomyopathies. LVNC has been reported in up to 40% of the general population, raising questions about whether it a distinct pathological entity, remodeling epiphenomenon, or merely an anatomical phenotype. The authors determined prevalence predictors healthy population using 4 cardiac magnetic resonance imaging diagnostic criteria. Volunteers >40 years age (N = 1,651) with no history cardiovascular...
The EarlyCDT-Lung test is a high specificity blood-based autoantibody biomarker that could contribute to predicting lung cancer risk. Here we report on the results of phase IV evaluation whether using and any subsequent CT scanning identify those at risk reduces incidence patients with stage III/IV/Unspecified diagnosis, compared standard clinical practice time study began. ECLS was randomised controlled trial 12 208 participants developing in Scotland. intervention arm received and, if...
The role of biomarkers in risk-based early detection lung cancer may enable screening to become cost effective and widely accessible. EarlyCDT-Lung is an example such a blood-based autoantibody biomarker which improve accessibility Low dose Computed Tomography (LDCT) for those at highest risk. We randomized 12 208 individuals aged 50–75 high risk developing either the test or standard clinical care. Outcomes were ascertained from Register Deaths Cancer Registry. Cox proportional hazards...
Randomised trials are at the heart of evidence-based healthcare, but methods and infrastructure for conducting these sometimes complex studies largely evidence free. Trial Forge ( www.trialforge.org ) is an initiative that aims to increase base trial decision making and, in doing so, improve efficiency. This paper summarises a one-day workshop held Edinburgh on 10 July 2014 discuss how advance this initiative. We first outline problem inefficiency randomised go describe Forge. present...
<h3>Objective</h3> To evaluate the role of genetic variation at <i>DMPK</i> locus on symptomatic diversity in 250 adult, ambulant patients with myotonic dystrophy type 1 (DM1) recruited to Observational Prolonged Trial Myotonic Dystrophy Type Improve Quality Life—Standards, a Target Identification Collaboration (OPTIMISTIC) clinical trial. <h3>Methods</h3> We used small pool PCR correct age sampling biases and estimate progenitor allele CTG repeat length somatic mutational dynamics, AciI...
Significance Statement Among patients with CKD, vascular calcification is common and an independent contributor to increased stiffness risk. The authors investigated whether supplementation vitamin K, a cofactor for proteins that inhibit calcification, could improve arterial in parallel-group, double-blind, randomized, placebo-controlled trial involving aged 18 or older CKD stage 3b 4. Vitamin K2 12 months did not stiffness, as measured by pulse wave velocity. An updated meta-analysis...
Lung cancer is the most common cause of related death worldwide. The majority cases are detected at a late stage when prognosis poor. EarlyCDT®-Lung Test detects autoantibodies to abnormal cell surface proteins in earliest stages disease which may allow tumour detection an earlier thus altering prognosis. primary research question is: Does using identify those high risk lung cancer, followed by X-ray and computed tomography (CT) scanning, reduce incidence patients with late-stage (III & IV)...
Good glycaemic control in type 2 diabetes (T2DM) protects the microcirculation. Current guidelines suggest targets be relaxed advanced diabetes. We explored whether disease duration or pre-existing macrovascular complications attenuated association between hyperglycaemia and microvascular function. 743 participants with T2DM (n = 222), cardiovascular (CVD 183), both 177) neither (controls 161) from two centres UK, underwent standard clinical measures endothelial dependent (ACh) independent...
Abstract The evidence base available to trialists support trial process decisions—e.g. how best recruit and retain participants, collect data or share the results with participants—is thin. One way fill gaps in is run Studies Within A Trial, SWATs. These are self-contained research studies embedded within a host that aim evaluate explore alternative ways of delivering organising particular process. SWATs increasingly being supported by funders considered trialists, especially UK Ireland. At...
Approximately 50% of the forearm vasodilatation to intra-arterial infusions acetylcholine is mediated by endothelium-derived nitric oxide. These conclusions have been derived from venous occlusion plethysmographic measurements total blood flow during co-infusions and NG-monomethyl-L-arginine (L-NMMA), an inhibitor oxide synthase. Since plethysmography measures limb flow, relative proportion measurement skin cannot be determined precisely. To determine effects on specifically, we used laser...
Abstract Purpose: The STAKT study examined short-term exposure (4.5 days) to the oral selective pan-AKT inhibitor capivasertib (AZD5363) determine if this drug can reach its therapeutic target in sufficient concentration significantly modulate key biomarkers of AKT pathway and tumor proliferation. Patients Methods: was a two-stage, double-blind, randomized, placebo-controlled, “window-of-opportunity” patients with newly diagnosed ER+ invasive breast cancer. Stage 1 assessed 480 mg b.i.d....
Abstract Objective . To assess the effects of oral L‐arginine supplementation on cutaneous vascular responses in patients with primary Raynaud's phenomenon (RP). Methods Double‐blind, crossover comparison placebo versus (8 gm/day for 28 days). Cutaneous fingers were assessed during iontophoresis acetylcholine and sodium nitroprusside, which are endothelium‐dependent endothelium‐independent vasodilators. Results In control subjects, RP had diminished ‐independent vasodilatation ( P < 0.05,...
Written participant information materials are important for ensuring that potential trial participants receive necessary so they can provide informed consent. However, such frequently long and complex, which may negatively impact patient understanding willingness to participate. Improving readability, ease of comprehension presentation assist with improved recruitment. The Systematic Techniques Assisting Recruitment Trials (MRC START) study aimed develop evaluate interventions improve This...
Abstract Background Extended-spectrum beta-lactamase (ESBL) and AmpC-producing Enterobacterales are common causes of bloodstream infection. ESBL-producing bacteria typically resistant to third-generation cephalosporins result in a sizeable economic public health burden. may develop cephalosporin resistance through enzyme hyper-expression. In no observational study has the outcome treatment these infections been surpassed by carbapenems. Widespread use carbapenems drive development...
High response rates to research questionnaires can help ensure results are more representative of the population studied and provide increased statistical power, on which study may have been predicated. Improving speed quality reduce costs.We conducted a randomized within trial (SWAT) assess questionnaire rates, reminders sent, data completeness with unconditional compared conditional monetary incentives. Eligible individuals were mailed series psychological as follow-up baseline host...
Metabolic acidosis is more common with advancing chronic kidney disease, and has been associated impaired physical function, bone health, accelerated decline in function increased vascular risk. Although oral sodium bicarbonate widely used to correct metabolic acidosis, there exist potential risks of therapy including worsening hypertension fluid overload. Little trial evidence exists decide whether net benefit advanced particularly older people who are most commonly affected, whom quality...
BackgroundNafamostat mesylate is a potent in vitro antiviral agent that inhibits the host transmembrane protease serine 2 enzyme used by severe acute respiratory syndrome coronavirus for cell entry.MethodsThis open-label, pragmatic, randomized clinical trial Australia, New Zealand, and Nepal included noncritically ill hospitalized patients with disease 2019 (Covid-19). Participants were randomly assigned to usual care or plus nafamostat. The primary end point was death (any cause) receipt of...
Erythromelalgia (EM) is a chronic disorder characterized by intermittent burning pain, warmth and erythema of the extremities. Increasing local temperature dependency affected limb(s) precipitates symptoms, whereas direct cooling elevation can provide partial relief. Our previous findings showed that patients with EM have enhanced cutaneous vascular tone at rest during stimulation, which may be due to an increase in sympathetic neural activity. To test this, we measured skin vasoconstrictor...
Unrecognized myocardial infarctions (UMIs) have been described in 19–30% of the general population using late gadolinium enhancement (LGE) on cardiac magnetic resonance. However, these studies focused an unselected cohort including those with known cardiovascular disease (CVD). The aim current study was to ascertain prevalence UMIs a non-high-risk resonance imaging (MRI). A total 5000 volunteers aged >40 years no history CVD and 10-year risk <20%, as assessed by ATP-III score, were recruited...
Background Advanced chronic kidney disease is common in older people and frequently accompanied by metabolic acidosis. Oral sodium bicarbonate used to treat this acidosis, but evidence lacking on whether or not provides a net gain health quality of life for people. Objectives The objectives were determine oral therapy improves physical function, life, markers renal bone turnover vascular compared with placebo mild acidosis; assess the safety bicarbonate; establish cost-effective setting....
Background Erythromelalgia (EM) is a chronic disorder characterized by intermittent pain, warmth and erythema of the extremities. Symptoms can be precipitated increasing temperature affected limb partially relieved direct cooling. Materials methods Microvascular assessment was conducted under ‘hot’ (28°C) environmental conditions in 61 EM (EMI) patients 30 control subjects. Twenty with many symptoms were enrolled as an active group (EMII). Using laser Doppler flowmetry, basal skin...