Kirsty Wetherall
A5074601876- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Adolescent Sexual and Reproductive Health
- Diabetes Treatment and Management
- Erythropoietin and Anemia Treatment
- Iron Metabolism and Disorders
- Acute Myocardial Infarction Research
- Child and Adolescent Psychosocial and Emotional Development
- Vascular Procedures and Complications
- Pancreatic function and diabetes
- School Health and Nursing Education
- Hemoglobinopathies and Related Disorders
- Gout, Hyperuricemia, Uric Acid
- Case Reports on Hematomas
- Asthma and respiratory diseases
- Central Venous Catheters and Hemodialysis
- Cardiovascular Disease and Adiposity
- Chemical synthesis and pharmacological studies
- Vitamin K Research Studies
- Cardiovascular Issues in Pregnancy
- Psychiatric care and mental health services
- Adolescent and Pediatric Healthcare
- Youth Development and Social Support
- Coronary Interventions and Diagnostics
University of Glasgow
2018-2024
NIHR Nottingham Digestive Diseases Biomedical Research Unit
2020
University of Nottingham
2020
Sodium-glucose cotransporter 2 inhibitors reduce the risk of heart failure hospitalization and cardiovascular death in patients with reduced ejection fraction (HFrEF). However, their effects on cardiac structure function HFrEF are uncertain.We designed a multicenter, randomized, double-blind, placebo-controlled trial (the SUGAR-DM-HF [Studies Empagliflozin Its Cardiovascular, Renal Metabolic Effects Patients With Diabetes Mellitus, or Prediabetes, Heart Failure]) to investigate empagliflozin...
Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous studies have shown that allopurinol has positive effects on several cardiovascular parameters. The ALL-HEART study aimed determine whether improves major outcomes in ischaemic heart disease.ALL-HEART was multicentre, prospective, randomised, open-label, blinded-endpoint trial done 18 regional centres England and Scotland, recruited from 424 primary care practices. Eligible were aged 60 years or older, disease...
Abstract Background and Aims What is the relationship between blood tests for iron deficiency, including anaemia, response to intravenous in patients with heart failure? Methods In IRONMAN trial, 1137 failure, ejection fraction ≤ 45%, either serum ferritin < 100 µg/L or transferrin saturation (TSAT) 20% were randomized ferric derisomaltose (FDI) usual care. Relationships investigated baseline anaemia severity, TSAT, changes haemoglobin from 4 months, Minnesota Living Heart Failure...
The aim of this study was to mechanistically investigate associations among cigarette smoking, microvascular pathology, and longer term health outcomes in patients with acute ST-segment elevation myocardial infarction (MI). pathophysiology reperfusion injury prognosis smokers MI is incompletely understood. Patients were prospectively enrolled during emergency percutaneous coronary intervention. Microvascular function the culprit artery measured invasively. Contrast-enhanced magnetic...
Significance Statement Among patients with CKD, vascular calcification is common and an independent contributor to increased stiffness risk. The authors investigated whether supplementation vitamin K, a cofactor for proteins that inhibit calcification, could improve arterial in parallel-group, double-blind, randomized, placebo-controlled trial involving aged 18 or older CKD stage 3b 4. Vitamin K2 12 months did not stiffness, as measured by pulse wave velocity. An updated meta-analysis...
The rationale for our study was to investigate the pathophysiology of microvascular injury in patients with acute ST-segment-elevation myocardial infarction relation a history hypertension. We undertook cohort using invasive and noninvasive measures injury, cardiac magnetic resonance imaging at 2 days 6 months, assessed health outcomes longer term. Three hundred twenty-four (mean age, 59 [12] years; blood pressure, 135 [25] / 79 [14] mm Hg; 237 [73%] male, 105 [32%] antecedent hypertension)...
Abstract Aims Subcutaneous (SC) furosemide has potential advantages over intravenous (IV) by enabling self-administration or administration a lay caregiver, such as facilitating early discharge, preventing hospitalizations, and in palliative care. A high-concentration, pH-neutral formulation been developed for SC via small patch infusor pump. We aimed to compare the bioavailability, pharmacokinetic (PK), pharmacodynamic (PD) profiles of new with conventional IV describe first use bespoke...
The aims of this study were to ascertain the relationship between level physical activity and outcomes discriminate determinants performance or avoidance.CLARIFY is an international prospective registry 32,370 consecutive outpatients with stable coronary artery disease who followed for up five years. Patients grouped according frequency activity: i) sedentary (n = 5223; 16.1%); ii) only light most weeks (light; n 16,634; 51.4%); iii) vigorous once twice per week (vigorous ≤ 2×; 5427; 16.8%);...
Young people in the UK are at highest risk of sexually transmitted infections and report higher levels unsafe sex than any other age group. Involving peer supporters intervention delivery is acceptable to students effective reducing behaviours via 'diffusion innovation', particularly where influential their networks. Informal peer-led interventions offer a useful alternative didactic teaching, which has shown limited effects. Building on successful ASSIST anti-smoking intervention, 'STis And...
Background Young people report higher levels of unsafe sex and have rates sexually transmitted infections than any other age group. Schools are well placed to facilitate early intervention, but more effective approaches required. Peer-led can augment school-based education, often fail capitalise on mechanisms social influence. The potential using media in sexual health has not been tested school settings. Objectives Finalise the design Sexually Transmitted And Sexual Health (STASH)...
Effective sex education is the key to good sexual health. Peer-led approaches can augment teacher-delivered education, but many fail capitalise on mechanisms of social influence. We assessed feasibility a novel intervention (STASH) in which students (aged 14-16) nominated as influential by their peers were recruited and trained Peer Supporters (PS). Over 5-10-week period, they spread positive health messages friends year group, both in-person via media, supported do so weekly...
Various informant-based questionnaires are used in clinical practice to screen for pre-stroke cognitive problems. However, there is no guidance on which tool should be preferred. We compared the validity of two most commonly tools.
Background Stronger social and emotional well-being during primary school is positively associated with the health educational outcomes of young people. However, there little evidence on which programmes are most effective for improving well-being. Objective The objective was to rigorously evaluate Social Emotional Education Development (SEED) intervention process pupils’ Design This a stratified cluster randomised controlled trial embedded economic evaluations. Thirty-eight schools were...
Abstract Background Clinical guidelines for depression in adults recommend the use of outcome measures and stepped care models routine care. Such are based on symptom severity, but response to treatment is likely also be influenced by personal contextual factors. This observational study a clinical sample sought examine extent which “symptom severity measures” “complexity assess different aspects patient experience, how they might relate outcomes, including disengagement from treatment....
Arteriovenous fistulae (AVF) are the 'gold standard' vascular access for haemodialysis. Universal usage is limited, however, by a high early failure rate. Several small, single-centre studies have demonstrated better patency rates AVF created under regional anaesthesia (RA) compared with local (LA). The mechanistic hypothesis that sympathetic blockade associated RA causes vasodilatation and increased blood flow through new AVF. Despite this, considerable variation in practice exists UK. A...
Abstract Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of heart failure hospitalisation and cardiovascular death in patients with reduced ejection fraction (HFrEF). However, their effects on carbohydrate antigen 125 (CA-125) are uncertain. CA-125 has a potential role HFrEF assessment congestion, guiding decongestive therapies, predicting outcome. Purpose This exploratory biomarker substudy SUGAR-DM-HF trial investigated relationship levels markers effect SGLT2...