A5090467089- Cerebral Palsy and Movement Disorders
- Family and Disability Support Research
- Infant Development and Preterm Care
- Stroke Rehabilitation and Recovery
- Botulinum Toxin and Related Neurological Disorders
- Neonatal and fetal brain pathology
- Children's Physical and Motor Development
- Childhood Cancer Survivors' Quality of Life
- Adolescent and Pediatric Healthcare
- Occupational Therapy Practice and Research
- Mental Health and Patient Involvement
- Inclusion and Disability in Education and Sport
- Assistive Technology in Communication and Mobility
- Balance, Gait, and Falls Prevention
- Child and Adolescent Health
- Chronic Disease Management Strategies
- Health Sciences Research and Education
- Nerve Injury and Rehabilitation
- Neurogenetic and Muscular Disorders Research
- Health disparities and outcomes
- Healthcare innovation and challenges
- Delphi Technique in Research
- Muscle Physiology and Disorders
- Primary Care and Health Outcomes
- Educational Research and Analysis
Bath Spa University
2025
Queen's University Belfast
2015-2024
Southampton Solent University
2022
King's College Hospital
2022
University of Dundee
2021
University of Glasgow
2020
Australian Catholic University
2014-2019
Iranshahr University
2012-2016
Temple University
2016
Musgrave Park Hospital
2005-2011
Abstract Immunohistochemical staining of 16 brains post mortem from patients with progressive multiple sclerosis and two biopsy specimens acute demyelinating disease was performed using a panel monoclonal antibodies reactive T cells T‐cell subsets, B cells, Ia (HLA‐DR) antigens. Lymphocytic perivascular cuffs were most prominent at the edge active plaques occasionally seen in areas no evidence demyelination or macrophage infiltration. Perivascular consisted predominantly + many T8 variable...
Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous studies have shown that allopurinol has positive effects on several cardiovascular parameters. The ALL-HEART study aimed determine whether improves major outcomes in ischaemic heart disease.ALL-HEART was multicentre, prospective, randomised, open-label, blinded-endpoint trial done 18 regional centres England and Scotland, recruited from 424 primary care practices. Eligible were aged 60 years or older, disease...
Abstract Fresh‐frozen autopsy material containing active inflammatory lesions from 9 different patients with multiple sclerosis (MS) was analyzed by immunocytochemistry using a panel of monoclonal antibodies, and dual‐label immunocytochemical method developed which permitted the simultaneous detection two surface Marchkers on single cell. We now report following. (1) The predominant T‐cell phenotype within MS is CD2,3,8. This Marchks suppressor‐cytotoxic subset. (2) These cells do not...
Aim The aim of this study was to use a prospective longitudinal describe age-related trends in energy efficiency during gait, activity, and participation ambulatory children with cerebral palsy (CP). Method Gross Motor Function Measure (GMFM), Paediatric Evaluation Disability Inventory (PEDI), Lifestyle Assessment Questionnaire-Cerebral Palsy (LAQ-CP) scores, (oxygen cost) gait were assessed representative sample 184 (112 male; 72 female; mean age 10y 9mo; range 4–16y) CP. Ninety-four had...
Abstract Background Children with cerebral palsy (CP) experience a variety of functional limitations depending on the severity their condition that impact participation in day‐to‐day activities. Methods The gross motor function and restrictions experienced by 60 ambulant children CP (mean age 11.04 years) were assessed using Gross Motor Function Measure (GMFM‐88) Lifestyle Assessment Questionnaire – Cerebral Palsy (LAQ‐CP). Results A significant negative correlation existed between GMFM‐88...
The concurrent validity of a 1 minute walk test at child's maximum walking speed was assessed in children with bilateral spastic cerebral palsy (BSCP). distance covered during the compared children's gross motor function as by Gross Motor Function Measure (GMFM). Twenty-four male and 10 female CP (mean age 11y, range 4 to 16y) participated study. Classification System (GMFCS) levels were; level I (n=3), II (n=17), III (n=10), IV (n=4). Participants had clinical diagnoses symmetrical diplegia...
The aim of the study was to establish if a relationship exists between energy efficiency gait, and measures activity limitation, participation restriction, health status in representative sample children with cerebral palsy (CP). Secondary aims were investigate potential differences clinical subtypes gross motor classification, explore other relationships under investigation. A longitudinal 184 ambulant CP conducted (112 males, 72 females; 94 had unilateral spastic C P, 84 bilateral six...
To assess if young people with cerebral palsy experience and health professionals provide practices that may improve transition from child to adult services.Seventy-five (31 females, 44 males; mean age 18 years 5 months [standard deviation 2 months]) and/or parents 108 completed a questionnaire describing their or the provision of nine practices.The percentage reporting each practice was: appropriate parent involvement (90%); promotion self-efficacy (37%); named worker who supports process...
Abstract Aim To explore the experiences of health services among adults with cerebral palsy (CP) in Ireland, from perspectives CP, their support people, and service providers. Method A qualitative descriptive study design was used. In‐depth semi‐structured interviews were conducted between March August 2021 people who supported them, professionals. Thematic analysis used to evaluate data. Results Twenty‐one seven (family carer[s], spouse or partner, friend), 15 providers participated study....
A randomized placebo-controlled trial was carried out to investigate the efficacy of neuromuscular electrical stimulation (NMES) and threshold (TES) in strengthening quadriceps muscles both legs children with cerebral palsy (CP). Sixty (38 males, 22 females; mean age 11y [SD 3y 6mo]; range 5-16y) were one following groups: NMES (n=18), TES (n=20), or placebo (n=22). Clinical presentations diplegia (n=55), quadriplegia (n=1), dystonia ataxia non-classifiable CP (n=2). Thirty-four walked...
While passive range of motion (PROM) is commonly used to inform decisions on therapeutic management, knowledge PROM children with spastic cerebral palsy (CP) limited. A population-based sample 178 CP (110 male; unilateral, n = 94; bilateral, 84; age 4–17 years) and 68 typically developing (24 were recruited the study. All able walk a minimum 10 m over straight flat course, or without assistive devices. Gross Motor Function Classification System (GMFCS) levels participants were: Level I 55,...
Objectives This study aimed to report the prevalence and clinical characteristics of adults with cerebral palsy (CP) in a geographically defined region UK. Design setting Cross-sectional using Northern Ireland Cerebral Palsy Register (NICPR). Participants All validated cases known NICPR, born 1981–2001 alive resident at age 19 years were included. Results The included 1218 persons CP aged 19–39 years, 46 whom died adulthood. was 2.38 per 1000. majority had spastic (n=1132/1218, 93%) could...
Abstract Background Using digital technologies to provide services and supports remotely may improve efficiency accessibility of healthcare, support people with disabilities live independently. This study aimed explore the experience using access disability during Covid-19 pandemic, from perspective disabilities, families service providers. Methods a multiple case design, we purposively sampled three cases based on user characteristics geographical reach service. We conducted semi-structured...
To establish consensus among adolescents with a physical disability regarding their priorities for enhancing participation in activity and help inform the design of future interventions activity.
<ns3:p>Background Poor transition from child- to adult-oriented healthcare may lead negative outcomes and dissatisfaction with services in adulthood. The aim of the study was examine how is provided experienced by young people cerebral palsy Ireland. This report provides integrated quantitative qualitative findings implications based on totality knowledge generated. Methods A convergent parallel mixed-methods conducted. Data were collected aged 16–22 years, parents, health professionals...