A5083418135- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Plant Virus Research Studies
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Allergic Rhinitis and Sensitization
- Cardiac pacing and defibrillation studies
- Nutrition and Health in Aging
- Cardiac Valve Diseases and Treatments
- Food Allergy and Anaphylaxis Research
- Pulmonary Hypertension Research and Treatments
- Cardiac Structural Anomalies and Repair
- Plant Pathogenic Bacteria Studies
- Plant Disease Resistance and Genetics
- Inflammatory Biomarkers in Disease Prognosis
- Advanced MRI Techniques and Applications
- Cardiac Arrhythmias and Treatments
- Cocoa and Sweet Potato Agronomy
- Frailty in Older Adults
- Contact Dermatitis and Allergies
- Diabetes Treatment and Management
- Phytoplasmas and Hemiptera pathogens
- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Potassium and Related Disorders
Osaka Police Hospital
2017-2025
Toyonaka Municipal Hospital
2025
Osaka City General Hospital
2020
Osaka University
1998-2019
Chiba University
2017-2019
Centre for Process Innovation
2016
Kobe City Medical Center General Hospital
2013
St. Luke's International Hospital
2013
Central Region Agricultural Research Center
2012
Kamiichi General Hospital
2006-2009
Background The female preponderance in heart failure with preserved ejection fraction (HFpEF) is a distinguishing feature of this disorder, but the association sex degree diastolic dysfunction and clinical outcomes among individuals HFpEF remains unclear. Methods Results We conducted prospective, multicenter, observational study patients (PURSUIT‐HFpEF [Prospective Multicenter Observational Study Patients Heart Failure Preserved Ejection Fraction]: UMIN000021831). Between 2016 2019, 871 were...
Significance We identified hypoxia-inducible domain family, member 1A (Higd1a) as a positive regulator of cytochrome c oxidase (CcO). CcO, the terminal component mitochondrial electron transfer system, reductively converts molecular oxygen to water coupled pump protons across inner membrane. Higd1a is transiently induced under hypoxic conditions and increases CcO activity by directly interacting with in vicinity its active center. Induction leads increased consumption subsequent ATP...
Background Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) are novel inflammation markers. Their combined usefulness for estimating the prognosis of patients with heart failure preserved ejection fraction (HFpEF) admitted acute decompensated remains elusive. Methods Results We investigated 1026 registered in Prospective Multicenter Observational Study Patients Heart Failure Preserved Ejection Fraction. Both NLR PLR values were measured at time admission. Comorbidity...
Abstract Fresh‐frozen autopsy material containing active inflammatory lesions from 9 different patients with multiple sclerosis (MS) was analyzed by immunocytochemistry using a panel of monoclonal antibodies, and dual‐label immunocytochemical method developed which permitted the simultaneous detection two surface Marchkers on single cell. We now report following. (1) The predominant T‐cell phenotype within MS is CD2,3,8. This Marchks suppressor‐cytotoxic subset. (2) These cells do not...
Background: Recent accumulating evidence reveals that the right ventricular (RV)-pulmonary artery (PA) uncoupling is associated with poor outcome in patients heart failure (HF), RV dysfunction, and pulmonary hypertension. However, prognostic utility of RV-PA HF preserved ejection fraction (HFpEF) remains elusive. In this study, we aim to investigate associations outcomes HFpEF inpatients. Methods: We prospectively studied 655 patients, registered PURSUIT-HFpEF (The Prospective Multicenter...
Abstract Aims The HFA‐PEFF score is a part of the stepwise diagnostic algorithm heart failure with preserved ejection fraction (HFpEF). We aimed to evaluate prognostic significance on clinical outcomes in patients HFpEF. Methods and results Prospective mUlticenteR obServational stUdy patIenTs Heart Failure Ejection Fraction (PURSUIT‐HFpEF) study prospective, multicentre, observational which collaborating hospitals Osaka record clinical, echocardiographic, outcome data acute decompensated...
Background An association between uric acid (UA) and cardiovascular diseases, including heart failure (HF), has been reported. However, whether UA is a causal risk factor for HF controversial. In particular, the prognostic value of lowering in patients with preserved ejection fraction (HFpEF) unclear. Methods Results We enrolled HFpEF from PURSUIT‐HFpEF (Prospective Multicenter Observational Study Patients With Heart Failure Preserved Ejection Fraction) registry. investigated was correlated...
Objective Our previously established machine learning-based clustering model classified heart failure with preserved ejection fraction (HFpEF) into four distinct phenotypes. Given the heterogeneous pathophysiology of HFpEF, specific medications may have favourable effects in phenotypes HFpEF. We aimed to assess effectiveness on clinical outcomes using a real-world HFpEF registry dataset. Methods This study is posthoc analysis PURSUIT-HFpEF registry, prospective, multicentre, observational...
The effect of torasemide and furosemide therapy was compared in 50 patients who had chronic heart failure symptoms [NYHA class II-III] despite long-term with both low-dose angiotensin-converting enzyme inhibitors. In this randomized 6-month, open-label trial, baseline follow-up echocardiograms neurohumoral assays were obtained 25 group F (continued same dose oral at 20-40 mg/day) T (received 4-8 mg/day place furosemide). At 6 months, parameters unchanged whereas the a lower left ventricular...
Abstract Aims The prognostic value of serum chloride level has been reported primarily in patients with heart failure reduced ejection fraction, and hence, there is limited evidence preserved fraction (HFpEF). This study was conducted to clarify the relationship between clinical outcomes HFpEF acute decompensated (ADHF). Methods results Patient data were extracted from Prospective mUlticenteR obServational stUdy patIenTs Heart Failure Preserved Ejection Fraction (PURSUIT HFpEF) study, a...
Background Using machine learning for the phenotyping of patients with heart failure preserved ejection fraction (HFpEF) has emerged as a novel approach to understanding pathophysiology and stratifying patients. Our objective is perform HFpEF in stable phase investigate phenotypic trajectory from acute worsening phase. Methods The present study post hoc analysis PURSUIT‐HFpEF (Prospective Multicenter Observational Study Patients Heart Failure Preserved Ejection Fraction) study. We applied...
An intramyocardial dissecting hematoma (IMH) is a rare but potentially fatal complication of an acute myocardial infarction (AMI), typically resulting from hemorrhagic dissection within the spiral fibers. We present case 80-year-old man who experienced chest symptoms persisting for more than 24 hours. Despite immediate revascularization, patient unexpectedly developed cardiogenic shock during hospitalization and subsequently died. A pathological autopsy revealed relatively newly formed in...
Background: Although insulin resistance (IR) is associated with a higher risk of incident heart failure (HF), it not fully understood whether IR could affect clinical outcomes in patients established HF. We investigated the relationship between triglyceride-glucose (TyG) index, simple surrogate marker for IR, and HF preserved ejection fraction (HFpEF). Methods: This retrospective analysis from PURSUIT-HFpEF registry included 917 hospitalized decompensated HFpEF. The TyG index was calculated...
Abstract Aims The impacts of high density lipoprotein cholesterol (HDL‐C) as an anti‐inflammatory and C reactive protein (CRP) inflammatory properties on the pathogenesis heart failure were reported. At present, clinical significance HDL‐C/CRP ratio in with preserved ejection fraction (HFpEF) patients remains unknown. Methods results We examined data 796 consecutive HFpEF (left ventricular ≥50%) hospitalized due to acute decompensated from PURSUIT‐HFpEF registry, a prospective, multicentre...
Objective The pathophysiological heterogeneity of heart failure with preserved ejection fraction (HFpEF) makes the conventional ‘one-size-fits-all’ treatment approach difficult. We aimed to develop a stratification methodology identify distinct subphenotypes acute HFpEF using latent class analysis. Methods established prospective, multicentre registry decompensated HFpEF. Primary candidates for analysis were patient data on hospital admission (160 features). subset was categorised based...
Abstract Under hypertrophic stimulation, cardiomyocytes enter a hypermetabolic state and accelerate biomass accumulation. Although the molecular pathways that regulate protein levels are well-studied, functional implications of RNA accumulation its regulatory mechanisms in remain elusive. Here, we have elucidated quantitative kinetics through single cell imaging c-Myc ( Myc )-mediated analytical model using cultured cardiomyocytes. Nascent labeling combined with demonstrated significantly...
Atrial fibrillation (AF) is common in heart failure with preserved ejection fraction (HFpEF).
<i>Background:</i>Japanese cedar <i>(Cryptomeria japonica)</i> pollen is a major cause of seasonal pollinosis in Japan. Protease activity the grains may trigger pro-allergic responses but no such proteases have yet been identified as allergens. <i>Objectives:</i>We report molecular cloning and immunochemical characterization novel <i>C. japonica </i>pollen allergen belonging to aspartic protease family. <i>Methods:</i>We focused on...
This study investigated the impact of systemic inflammation on bleeding risk in non-valvular atrial fibrillation (NVAF) patients treated with direct oral anticoagulants (DOAC).
Abstract Aims Low‐density lipoprotein cholesterol (LDL‐C), anaemia and low platelets have been associated with worse clinical outcomes in heart failure patients. We investigated the relationship between combination of these three components outcome patients preserved ejection fraction (HFpEF). Methods results examined data 1021 HFpEF hospitalized acute decompensated (HF) from PURSUIT‐HFpEF registry, a prospective, multicenter observational study. The enrolled were classified into four groups...