A5032131242- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Polysaccharides and Plant Cell Walls
- Food Allergy and Anaphylaxis Research
- Growth Hormone and Insulin-like Growth Factors
- Allergic Rhinitis and Sensitization
- Gestational Diabetes Research and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Spine and Intervertebral Disc Pathology
- Bone Tissue Engineering Materials
- Heterotopic Ossification and Related Conditions
- Hip and Femur Fractures
- Dermatology and Skin Diseases
- Diabetes Treatment and Management
- Bone health and treatments
- Electrospun Nanofibers in Biomedical Applications
- Ion channel regulation and function
- Skin and Cellular Biology Research
- Lipoproteins and Cardiovascular Health
- Hormonal Regulation and Hypertension
- Fibroblast Growth Factor Research
- Connective tissue disorders research
- Nausea and vomiting management
- Pancreatic function and diabetes
- Genetic Syndromes and Imprinting
Nippon Medical School Hospital
2023-2025
Sumitomo Hospital
2024
Osaka Police Hospital
2019-2023
Osaka University
1993-2021
NTT WEST Osaka Hospital
2014-2018
Keio University
2018
NTT (United States)
2016
Creative Research Enterprises (United States)
2015
Osaka City General Hospital
2014
Itami City Hospital
2013
Bone homeostasis is regulated by communication between bone-forming mature osteoblasts (mOBs) and bone-resorptive osteoclasts (mOCs). However, the spatial-temporal relationship mode of interaction in vivo remain elusive. Here we show, using an intravital imaging technique, that mOB mOC functions are via direct cell-cell contact these cell types. The mOBs mOCs mainly occupy discrete territories steady state, although detected spatiotemporally limited areas. In addition, a pH-sensing...
OBJECTIVE We have already reported that A1C is elevated because of iron deficiency in late pregnancy among nondiabetic pregnant women. This report examined whether the same phenomenon observed women with diabetes. RESEARCH DESIGN AND METHODS longitudinal study was conducted 17 diabetes (20-35 weeks pregnancy). A1C, serum glycated albumin, erythrocyte indexes, and metabolism indexes were measured. RESULTS levels significantly increased pregnancy, whereas albumin showed no significant changes....
A1C levels have been shown to be elevated in relation glycemia late pregnancy, although the precise mechanisms remain undetermined. We hypothesized that iron deficiency is involved increase pregnancy.In study 1, A1C, serum glycated albumin, erythrocyte indexes, and metabolism indexes were determined 47 nondiabetic pregnant women not receiving supplementation who divided into four groups according gestational period (group I, 21-24 weeks; group II, 25-28 III, 29-32 IV, 33-36 weeks). In 2,...
Abstract Bone morphogenetic protein (BMP)-2 plays a central role in bone-tissue engineering because of its potent bone-induction ability. However, the process BMP-induced bone formation vivo remains poorly elucidated. Here, we aimed to establish method for intravital imaging entire BMP-2-induced ectopic formation. Using multicolor transgenic mice, visualized spatiotemporal induction, including appearance and motility osteoblasts osteoclasts, angiogenesis, collagen-fiber formation,...
Abstract Advanced glycation endproducts (AGEs), which result from nonenzymatic reactions of glucose with tissue proteins, have been shown to accumulate on long-lived proteins in advanced aging and diabetes mellitus. Thus, AGEs implicated some the chronic complications associated these disorders. In this study, we investigated effects glucose-modified protein production potent bone resorption factors by cells derived explants human bone. stimulated release interleukin-6 (IL-6) culture...
Vascular cell adhesion molecule-1 (VCAM-1) has been shown to be highly expressed in atherosclerotic lesions. Although the soluble form of VCAM-1 (sVCAM-1) is detected human sera, relation between degree atherosclerosis and serum sVCAM-1 level not defined. In present study, concentrations were measured sera from 101 Japanese NIDDM patients. The mean ± SD concentration 26 patients with symptomatic vascular diseases (789 187 ng/ml) was higher than that 75 without disease (664 ±175 ng/ml). Among...
Previous studies showed higher risk of cardiovascular and cerebrovascular (CCV) events in primary aldosteronism compared with essential hypertension, but the patients these were limited to high plasma aldosterone concentration (PAC). The introduction aldosterone-renin ratio as screening test for led recognition normal PAC (nPA). However, there is no information on including nPA.In this retrospectively cross-sectional study, clinical features CCV event at diagnosis nPA investigated...
Osteoclastic bone resorption and osteoblastic formation/replenishment are closely coupled in metabolism. Anabolic parathyroid hormone (PTH), which is commonly used for treating osteoporosis, shifts the balance from osteoclastic to osteoblastic, although it unclear how these cells coordinately regulated by PTH. Here, we identify a serine protease inhibitor, secretory leukocyte inhibitor (SLPI), as critical mediator that involved PTH-mediated shift phase. Slpi highly upregulated osteoblasts...
The human and Old World primate genomes possess conserved endogenous retrovirus sequences that have been implicated in evolution, reproduction, carcinogenesis. Human (HERV)-K with 5′LTR-gag-pro-pol-env-rec/np9-3′LTR represents the newest family integrated into genome 1 to 5 million years ago. Although a high-level expression of HERV-K melanomas, breast cancers, terato-carcinomas has demonstrated, mechanism lineage-specific activation long terminal repeat (LTR) remains obscure. We studied...
Anamorelin is a selective ghrelin receptor agonist that used to treat cancer-related cachexia. Ghrelin stimulates growth hormone (GH) secretion. However, the association between anamorelin and hyperglycemia remains unclear. We herein report case of anamorelin-induced in patient with type 1 diabetes mellitus. A 67-year-old woman history was hospitalized because pleural effusion. After hospitalization, administered anamorelin. Four days after starting treatment, her blood glucose GH levels...
Most Japanese pediatric neurologists attempt other treatments before using adrenocorticotropic hormone (ACTH) therapy for West syndrome (WS), and even then, they use only a low-dose synthetic ACTH to avoid serious adverse effects. In this multi-institutional study, the authors analyzed initial effects, long-term outcome in patients treated with Japan.The medical records of 138 WS, who were first time at authors' institutions between 1989 1998, analyzed.At end therapy, excellent effect on...
<i>Background:</i> Konjac glucomannan (GM) is a well-known dietary fiber with various beneficial functions: the higher viscosity displayed stronger potency. However, high-viscous GM powders, ordinary konjac powder and highly purified were mostly unsuitable for application to food industries. Our aims are develop new physiological functions of low-viscous powder, pulverized or re-granulated fine GM, using murine model atopic dermatitis. <i>Methods:</i> Male 4-week-old...
Konjac is a traditional Japanese food with peculiar texture, and it has been suggested that its main ingredient, konjac glucomannan (KGM), ameliorates metabolic disorders such as diabetes hypercholesteremia. We have found feeding pulverized KGM (PKGM) prevents skin inflammation in murine model of atopic dermatitis. Here, we show dietary PKGM suppresses allergic rhinitis-like symptoms mice upon immunization nasal sensitization ovalbumin (OVA). The PKGM-fed showed much lower frequency sneezing...
Feeding with pulverized konjac glucomannan (PKGM) suppresses the development of eczema and hyper-IgE production in NC/Nga mice, a model atopic dermatitis. This study aimed to examine effects PKGM on scratching behavior skin inflammatory immune responses mice.Four-week-old mice were maintained for 8 or 9 weeks diet containing PKGM. Scratching clinical symptoms evaluated every 2 weeks. Effects cutaneous inflammation by histopathological analysis. Local expression levels substance P...
The aim of this study was to investigate the clinical and endocrinological characteristics adrenal incidentalomas in Osaka region, Japan. a multicenter retrospective analysis 150 patients with who underwent radiographic endocrine evaluations between 2005 2013. Most were discovered by computed tomography (77.0%) rest identified abdominal ultrasonography (14.6%), magnetic resonance imaging (4.2%), or positron emission (4.2%). Adrenal more frequently localized on left side than right. average...
Patients with Werner syndrome present diverse signs of aging that begin in adolescence. A Japanese nationwide survey was conducted to establish a registry could clarify the disease profile patients syndrome. The questionnaires were sent 7888 doctors. identified 116 diagnosed based on diagnosis criteria. Forty enrolled registry. Data clinical symptoms, treatment information, and laboratory examination from who provided informed consent collected. data at enrollment analyzed. patients' average...
<i>Background:</i>Japanese cedar <i>(Cryptomeria japonica)</i> pollen is a major cause of seasonal pollinosis in Japan. Protease activity the grains may trigger pro-allergic responses but no such proteases have yet been identified as allergens. <i>Objectives:</i>We report molecular cloning and immunochemical characterization novel <i>C. japonica </i>pollen allergen belonging to aspartic protease family. <i>Methods:</i>We focused on...
Abstract Aims Increases in C‐reactive protein (CRP) levels have been shown to be associated with cardiovascular diseases as well asymptomatic atherosclerosis and closely related traditional risk factors. The aim of this study was determine the clinical biochemical characteristics CRP non‐diabetic, non‐smoker subjects without hypertension. Methods A 75‐g oral glucose tolerance test performed on 305 Japanese aged 40–70 years who were undergoing health examinations. We recruited Subjects known...
Aim: Previous studies have been inconsistent results about the effects of statins on serum triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and high sensitivity C-reactive protein (hsCRP) levels. We therefore investigated pitavastatin lipid profiles hsCRP levels in patients with type 2 diabetes mellitus.Methods: The study population was 65 Japanese diabetic who had administered mg daily completed a 6-month follow-up. Serum lipids were measured before after treatment for 1, 3,...