A5023560262- Asthma and respiratory diseases
- Pancreatic and Hepatic Oncology Research
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Cancer Genomics and Diagnostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Economic and Financial Impacts of Cancer
- Lung Cancer Treatments and Mutations
- SARS-CoV-2 and COVID-19 Research
- Lung Cancer Diagnosis and Treatment
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Genetics and Plant Breeding
- Intensive Care Unit Cognitive Disorders
- Renal cell carcinoma treatment
- Inhalation and Respiratory Drug Delivery
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Viral Infections and Immunology Research
- Health Systems, Economic Evaluations, Quality of Life
- Crop Yield and Soil Fertility
- Genetic Mapping and Diversity in Plants and Animals
- Colorectal Cancer Treatments and Studies
- Frailty in Older Adults
- Immune Response and Inflammation
NHS Lanarkshire
2016-2025
Wishaw General Hospital
2011-2024
East Kent Hospitals University NHS Foundation Trust
2024
AstraZeneca (United Kingdom)
2024
AbbVie (United States)
2024
NIHR Newcastle Biomedical Research Centre
2023
Newcastle University
2023
Newcastle upon Tyne Hospitals NHS Foundation Trust
2023
Anand Agricultural University
2020-2023
University of Edinburgh
2023
Abstract TLRs are primary sensors of both innate and adaptive immune systems, where they play a pivotal role in the response directed against structurally conserved components pathogens. Synthetic bacterial lipopeptide Pam3CSK4 is TLR2 agonist capable modulating Th1 Th2 responses. This study examines therapeutic effect established airway inflammation murine model asthma. In mice previously sensitized challenged with OVA, given i.p. markedly reduced total inflammatory cell infiltrate...
Introduction Rotavirus vaccine efficacy ranges from >90% in high socio-economic settings (SES) to 50% low SES. With the imminent introduction of rotavirus SES countries, understanding reasons for reduced these could identify strategies improve performance. Methods We developed a mathematical model predict high, middle and based on data specific each setting incidence, protection conferred by natural infection immune response vaccination. then examined factors affecting efficacy. Results...
The EarlyCDT-Lung test is a high specificity blood-based autoantibody biomarker that could contribute to predicting lung cancer risk. Here we report on the results of phase IV evaluation whether using and any subsequent CT scanning identify those at risk reduces incidence patients with stage III/IV/Unspecified diagnosis, compared standard clinical practice time study began. ECLS was randomised controlled trial 12 208 participants developing in Scotland. intervention arm received and, if...
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence new variant lineages that have exacerbated COVID-19 pandemic. Some those variants were designated as concern/interest (VOC/VOI) by national or international authorities based on many factors including their potential impact vaccine-mediated protection from disease. To ascertain and rank risk VOCs VOIs, we analyze ability 14 (614G, Alpha, Beta, Gamma, Delta, Epsilon, Zeta, Eta, Theta,...
The role of biomarkers in risk-based early detection lung cancer may enable screening to become cost effective and widely accessible. EarlyCDT-Lung is an example such a blood-based autoantibody biomarker which improve accessibility Low dose Computed Tomography (LDCT) for those at highest risk. We randomized 12 208 individuals aged 50–75 high risk developing either the test or standard clinical care. Outcomes were ascertained from Register Deaths Cancer Registry. Cox proportional hazards...
Abstract Mast cell activation through the high affinity IgE receptor (FcεRI) is a critical component of atopic inflammation. The cytokine TGF-β1 has been shown to inhibit IgE-dependent mast activation, possibly serving dampen cell-mediated inflammatory responses. We present proof that inhibits FcεRI expression reversible pathway diminishes protein, but not mRNA, subunit proteins α, β, and γ. stability expressed assembled surface complex was unaltered by treatment. However, decreased rate...
Coronavirus disease-19 (COVID-19) infection causes persistent health problems such as breathlessness, chest pain and fatigue, therapies for the prevention early treatment of post-COVID-19 syndromes are needed. Accordingly, we investigating effect a resistance exercise intervention on capacity status following COVID-19 infection.A two-arm randomised, controlled clinical trial including 220 adults with diagnosis in preceding 6 months. Participants will be classified according to presentation:...
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Patients with aspirin sensitive asthma (ASA) can be desensitized to but the mechanisms by which this happens are unknown. To test hypothesis that there may a reduction in aspirin-induced leukotriene release following desensitization, we studied nine patients ASA, 37 +/- 2.3 yr of age (mean SEM) baseline FEV1 94 3.5%. Urinary E4 (LTE4) and were measured before after ingestion threshold dose leading 15% decrease FEV1, then at intervals when maintenance 600 mg was ingested. Prior maximum 15.3...
The economic burden of metastatic pancreatic cancer (mPC) is substantial while treatment options are limited. Little known about the patterns and healthcare costs among mPC patients who initiated first-line gemcitabine plus nanoparticle albumin-bound paclitaxel (nab-P + G) FOLFIRINOX.The MarketScan® claims databases were used to identify adults with ≥2 for cancer, 1 claim a secondary malignancy, completed ≥1 cycle nab-P G or FOLFIRINOX during 4/1/2013 3/31/2015, had continuous plan...
Glucocorticoid-induced TNFR family-related protein (GITR) is expressed at low levels on resting T cells, B cells and macrophages but high regulatory (Treg). Although GITR expression up-regulated CD4+ effector upon activation, the role of in Th1 Th2 cell development unclear. We report here that activation signalling by anti-GITR antibody markedly enhanced induction both cytokine production naive CD4+CD25- cells. Consistent with this observation, significantly key (T-bet) (GATA3) transcription...
The combination chemotherapy regimens of nab-paclitaxel plus gemcitabine (nab-p + G) and FOLFIRINOX (FFX) have each demonstrated improved survival compared with monotherapy in clinical trials for metastatic pancreatic cancer; however, limited comparative data exist. objective this study was to compare patient characteristics outcomes including time treatment failure overall patients cancer receiving first-line the community. We conducted a retrospective, multi-site, observational cohort...
Introduction: Despite a clinically relevant, statistically significant survival benefit with nab -paclitaxel plus gemcitabine and FOLFIRINOX vs single-agent for metastatic pancreatic cancer (mPC), little is known regarding their real-world effectiveness. We analyzed patients mPC using nationally representative electronic medical records database to address this unmet need. Methods: This retrospective analysis of the Navigating Cancer compared outcomes among who received first-line...
Abstract Rapid cycle genomic selection (RC‐GS) helps to shorten the breeding and reduce costs of phenotyping, thereby increasing genetic gains in terms both cost time. We implemented RC‐GS on two multi‐parent yellow synthetic (MYS) populations constituted by intermating ten elite lines involved each population, including four drought waterlogging tolerant donors commercial lines, with proven value. Cycle 1 (C ) was based phenotypic top 5% 500 S 2 families derived from MYS test‐crossed...
There is a need for improved therapies severe asthma. Lebrikizumab, humanized monoclonal antibody that binds to interleukin (IL)-13, under development the treatment of poorly controlled This article reviews potential role IL-13 in pathogenesis asthma, efficacy and safety lebrikizumab humans, progress patient selection therapy. T-helper (Th2) cell-derived cytokine implicated inflammatory responses including serum immunoglobulin-E synthesis, mucus hypersecretion, subepithelial fibrosis....
We compared real-world treatment patterns, resource utilization, and cost of care for patients with metastatic pancreatic cancer treated first-line nab-paclitaxel + gemcitabine or FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan, oxaliplatin).This was a retrospective study inpatient hospital-based outpatient data in the United States. Primary endpoints included median time to discontinuation (TTD) total per patient month. Secondary supportive costs hospitalization rate length.Overall, 345...
Erratic rainfall often results in intermittent drought and/or waterlogging and limits maize (Zea mays L.) productivity many parts of the Asian tropics. Developing climate-resilient germplasm possessing tolerance to these key abiotic stresses without a yield penalty under optimal growing conditions is challenge for breeders working stress-vulnerable agro-ecologies region. Breeding stress-resilient rainfed stress-prone ecologies identified as one priority areas CIMMYT-Asia program. We applied...
Introduction: Real-world comparative effectiveness, safety, and supportive care use of nab -paclitaxel plus carboplatin vs gemcitabine platinum were analyzed in patients with advanced or metastatic squamous cell non-small lung cancer (NSCLC). Materials methods: Patients who received ≥ 1 cycle first-line identified from the Navigating Cancer database. Clinical effectiveness endpoints included overall survival (OS) time to treatment discontinuation (TTD). Other safety utilization care. Cox...