Kristine A. Lacek
A5058339232- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- vaccines and immunoinformatics approaches
- COVID-19 Clinical Research Studies
- Genetic Associations and Epidemiology
- Cancer Immunotherapy and Biomarkers
- COVID-19 and Mental Health
- Genomics and Rare Diseases
- Bacteriophages and microbial interactions
- COVID-19 epidemiological studies
- Genetic Mapping and Diversity in Plants and Animals
- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
Centers for Disease Control and Prevention
2021-2024
National Center for Immunization and Respiratory Diseases
2023
UK Health Security Agency
2022
Imperial College London
2022
Murata (United States)
2022
Georgia Institute of Technology
2020
CDC has used national genomic surveillance since December 2020 to monitor SARS-CoV-2 variants that have emerged throughout the COVID-19 pandemic, including Omicron variant. This report summarizes U.S. trends in variant proportions from during January 2022-May 2023. During this period, remained predominant, with various descendant lineages reaching predominance (>50% prevalence). first half of 2022, BA.1.1 reached by week ending 8, followed BA.2 (March 26), BA.2.12.1 (May 14), and BA.5 (July...
Abstract To detect new and changing SARS-CoV-2 variants, we investigated candidate Delta–Omicron recombinant genomes from Centers for Disease Control Prevention national genomic surveillance. Laboratory bioinformatic investigations identified validated 9 genetically related viruses with a hybrid spike protein.
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence new variant lineages that have exacerbated COVID-19 pandemic. Some those variants were designated as concern/interest (VOC/VOI) by national or international authorities based on many factors including their potential impact vaccine-mediated protection from disease. To ascertain and rank risk VOCs VOIs, we analyze ability 14 (614G, Alpha, Beta, Gamma, Delta, Epsilon, Zeta, Eta, Theta,...
Abstract Recombination between SARS-CoV-2 virus variants can result in different viral properties (e.g., infectiousness or pathogenicity). In this report, we describe viruses with recombinant genomes containing signature mutations from Delta and Omicron variants. These are the first evidence for a Delta-Omicron hybrid Spike protein United States.
Few studies have prospectively assessed SARS-CoV-2 community infection in children aged 0 to 4 years. Information about incidence and clinical virological features young could help guide prevention mitigation strategies.To assess incidence, features, symptoms a prospective household cohort compare viral load by age group, symptoms, lineage children, older adults.This study enrolled 690 participants from 175 Maryland households with 1 or more years between November 24, 2020, October 15, 2021....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into numerous lineages with unique spike mutations and caused multiple epidemics domestically globally. Although COVID-19 vaccines are available, new variants the capacity for immune evasion continue to emerge. To understand characterize evolution of circulating SARS-CoV-2 in U.S., Centers Disease Control Prevention (CDC) initiated National Strain Surveillance (NS3) program received thousands clinical specimens from...
Abstract The early Omicron lineage variants evolved and gave rise to diverging lineages that fueled the COVID-19 pandemic in 2022. Bivalent mRNA vaccines, designed broaden protection against circulating future variants, were authorized by U.S. Food Drug Administration (FDA) August 2022 recommended Centers for Disease Control Prevention (CDC) September impact of bivalent vaccination on eliciting neutralizing antibodies homologous BA.4/BA.5 viruses as well emerging heterologous needs be...
Introductory The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence many new variant lineages that have exacerbated COVID-19 pandemic. Some those variants were designated as concern/interest (VOC/VOI) by national or international authorities based on factors including their potential impact vaccines. To ascertain and rank risk VOCs VOIs, we analyzed ability to escape from vaccine-induced antibodies. showed differential reductions...
Abstract The SARS-CoV-2 spike protein is a highly immunogenic and mutable that the target of vaccine prevention antibody therapeutics. This makes encoding S-gene an important sequencing target. community overwhelmingly adopted tiling amplicon-based strategies for entire genome. As virus evolved, primer mismatches inevitably led to amplicon drop-out. Given exposure host antibodies, mutation occurred here most rapidly, leading failure over insightful region To mitigate this, we developed...
The COVID-19 pandemic was accompanied by an unprecedented surveillance effort. resulting data were and will continue to be critical for control of SARS-CoV-2. However, some genomic methods experienced challenges as the virus evolved, in incomplete poor quality data. Complete coverage, especially S-gene, is important supporting selection vaccine candidates. As such, we developed a robust method target S-gene amplification sequencing. By focusing on imposing strict coverage metrics, hope...