A5073370603- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- COVID-19 and Mental Health
- Infection Control and Ventilation
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Bacteriophages and microbial interactions
- Immune Cell Function and Interaction
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
Centers for Disease Control and Prevention
2022-2024
National Center for Emerging and Zoonotic Infectious Diseases
2023-2024
Imperial College London
2022
UK Health Security Agency
2022
Murata (United States)
2022
Abstract To detect new and changing SARS-CoV-2 variants, we investigated candidate Delta–Omicron recombinant genomes from Centers for Disease Control Prevention national genomic surveillance. Laboratory bioinformatic investigations identified validated 9 genetically related viruses with a hybrid spike protein.
Abstract Recombination between SARS-CoV-2 virus variants can result in different viral properties (e.g., infectiousness or pathogenicity). In this report, we describe viruses with recombinant genomes containing signature mutations from Delta and Omicron variants. These are the first evidence for a Delta-Omicron hybrid Spike protein United States.
CDC continues to track the evolution of SARS-CoV-2, including Omicron variant and its descendants, using national genomic surveillance. This report summarizes U.S. trends in proportion estimates during May 2023-September 2024, a period when SARS-CoV-2 lineages primarily comprised descendants variants XBB JN.1. During summer fall 2023, multiple with immune escape substitutions emerged reached >10% prevalence, EG.5-like by June 24, FL.1.5.1-like August 5, HV.1 lineage September 30, HK.3-like...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into numerous lineages with unique spike mutations and caused multiple epidemics domestically globally. Although COVID-19 vaccines are available, new variants the capacity for immune evasion continue to emerge. To understand characterize evolution of circulating SARS-CoV-2 in U.S., Centers Disease Control Prevention (CDC) initiated National Strain Surveillance (NS3) program received thousands clinical specimens from...
Cytotoxic T lymphocytes (CTLs) mediate host defense against viral and intracellular bacterial infections tumors. However, the magnitude of CTL response their function needed to confer heterosubtypic immunity influenza virus infection are unknown. We addressed role CD8
Households are common places for spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We investigated factors associated with household transmission and acquisition SARS-CoV-2. children age <18 years were enrolled into prospective, longitudinal cohorts followed from August 2020 to 2021 in Utah, September New York City, November October Maryland. Participants self-collected nasal swabs weekly onset illness. Swabs tested SARS-CoV-2 using reverse transcription polymerase...
Abstract The SARS-CoV-2 spike protein is a highly immunogenic and mutable that the target of vaccine prevention antibody therapeutics. This makes encoding S-gene an important sequencing target. community overwhelmingly adopted tiling amplicon-based strategies for entire genome. As virus evolved, primer mismatches inevitably led to amplicon drop-out. Given exposure host antibodies, mutation occurred here most rapidly, leading failure over insightful region To mitigate this, we developed...
The COVID-19 pandemic was accompanied by an unprecedented surveillance effort. resulting data were and will continue to be critical for control of SARS-CoV-2. However, some genomic methods experienced challenges as the virus evolved, in incomplete poor quality data. Complete coverage, especially S-gene, is important supporting selection vaccine candidates. As such, we developed a robust method target S-gene amplification sequencing. By focusing on imposing strict coverage metrics, hope...