A5061118548- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Nail Diseases and Treatments
- COVID-19 and Mental Health
- Bacterial Identification and Susceptibility Testing
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Infectious Diseases and Mycology
- Plant Pathogens and Fungal Diseases
- Antimicrobial agents and applications
- Diphtheria, Corynebacterium, and Tetanus
- Biosensors and Analytical Detection
- Infection Control in Healthcare
- Clostridium difficile and Clostridium perfringens research
- Yeasts and Rust Fungi Studies
- Pneumonia and Respiratory Infections
- Parasitic Diseases Research and Treatment
- Plant-Microbe Interactions and Immunity
- Insect symbiosis and bacterial influences
- Invertebrate Immune Response Mechanisms
- Respiratory viral infections research
- Fungal and yeast genetics research
- Bacterial biofilms and quorum sensing
- HIV/AIDS drug development and treatment
- Infection Control and Ventilation
Centers for Disease Control and Prevention
2017-2024
National Center for Emerging and Zoonotic Infectious Diseases
2017-2024
CDC Foundation
2020
University of Florida
2017
ABSTRACT The emerging multidrug-resistant pathogenic yeast Candida auris represents a serious threat to global health. Unlike most other species, this organism appears be commonly transmitted within health care facilities and causes care-associated outbreaks. To better understand the epidemiology of pathogen, we investigated ability C. persist on plastic surfaces common in settings compared with that parapsilosis , species known colonize skin plastics. Specifically, compiled comparative...
The recent emergence of the multidrug-resistant and pathogenic yeast Candida auris continues to cause public health concern worldwide. C. is alarming because it causes care-associated outbreaks can establish invasive infections with high mortality rates. Transmission between patients facilitated by ability persistently colonize multiple body sites, including skin, survive for weeks on surfaces in care settings. Rapid identification colonized needed implement timely infection control...
Candida auris is an emerging multidrug-resistant yeast that contaminates healthcare environments causing healthcare-associated outbreaks. The mechanisms facilitating contamination are not established.
Candida auris is a multidrug-resistant pathogenic yeast whose recent emergence of increasing public-health concern. C. can colonise multiple body sites, including patients' skin, and survive for weeks in the health care environment, facilitating patient-to-patient transmission fueling care-associated outbreaks. Rapid accurate detection colonisation essential timely implementation infection control measures to prevent transmission. Currently, axilla/groin composite swabs, used assess status,...
Few studies have prospectively assessed SARS-CoV-2 community infection in children aged 0 to 4 years. Information about incidence and clinical virological features young could help guide prevention mitigation strategies.To assess incidence, features, symptoms a prospective household cohort compare viral load by age group, symptoms, lineage children, older adults.This study enrolled 690 participants from 175 Maryland households with 1 or more years between November 24, 2020, October 15, 2021....
Candida auris is an emerging, multidrug-resistant yeast that can spread rapidly in healthcare settings. Phenotypic switching has been observed other species and potentially interfere with correct identification. The aim of this study to address misidentification C. by describing alternate phenotypes after broth enrichment subculturing on CHROMagar Candida. Each isolate displayed different frequencies phenotypic switching, suggesting a strain variability. Increased knowledge the multiple...
Abstract We tested 9 disinfectants against Candida auris using the quantitative disk carrier method EPA-MB-35-00: 5 products with hydrogen peroxide or alcohol-based chemistries were effective and 4 quaternary ammonium compound-based not. This work supported a FIFRA Section 18 emergency exemption granted by US Environmental Protection Agency to expand disinfectant guidance for C. auris.
Abstract Background Nikkomycin Z is a competitive inhibitor of chitin synthase—an enzyme needed for synthesis the fungal cell wall. shows promise as treatment coccidioidomycoses and mixed activity has been described against other fungi yeast. To our knowledge, it not previously tested emerging pathogen Candida auris. Objectives determine in vitro nikkomycin C. Methods was by broth microdilution panel 100 isolates genetically diverse auris from around world. Results showed isolates, with an...
Invasive mold diseases (IMDs) cause severe illness, but public health surveillance data are lacking. We describe collected from a laboratory-based, pilot IMD system. During 2017-2019, the Emerging Infections Program conducted active at 3 Atlanta-area hospitals. ascertained potential cases by reviewing histopathology, culture, and Aspergillus galactomannan results classified patients as having an case (based on European Organization for Research Treatment of Cancer/Invasive Fungal Cooperative...
CHROMagar
Households are common places for spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We investigated factors associated with household transmission and acquisition SARS-CoV-2. children age <18 years were enrolled into prospective, longitudinal cohorts followed from August 2020 to 2021 in Utah, September New York City, November October Maryland. Participants self-collected nasal swabs weekly onset illness. Swabs tested SARS-CoV-2 using reverse transcription polymerase...
Abstract We characterized 2 clusters of blastomycosis cases in Minnesota, USA, using whole-genome sequencing and single-nucleotide polymorphism analyses. Blastomyces gilchristii was confirmed as the cause infection. Genomic analyses corresponded with epidemiologic findings for B. infections, demonstrating utility genomic methods future outbreak investigations.
The immune response of Drosophila melanogaster is complex and involves both specific general responses to parasites. In this study we tested for cross-immunity bacteria viruses by scoring the incidence infection with vertically transmitted Sigma virus (DMelSV) in progeny a cross between females transmitting DMelSV at high frequencies males from lines subjected three selection regimes related resistance Bacillus cereus . There was no significant difference transmission among regimes, though...
Abstract Background The Centers for Disease Control and Prevention’s Active Bacterial Core surveillance (ABCs) identified increased serotype 4 invasive pneumococcal disease (IPD), particularly among adults experiencing homelessness (AEH). Methods We quantified IPD cases during 2016-2022. Employing genomic-based characterization of isolates, we serotype-switch variants. Recombinational analyses were used to identify the genetic donor recipient strains that generated a progeny strain....
ABSTRACT This report describes the complete genome sequence assemblies from four representative isolates of human pathogen Corynebacterium belfantii . These data provide necessary references to aid accurate sequence-based species discrimination among closely related spp. pathogens.
The HIV integrase inhibitor, dolutegravir (DTG), in the absence of eliciting (int) resistance, has been reported to select mutations virus 3'-polypurine tract (3'-PPT) adjacent 3'-LTR U3. An analog DTG, cabotegravir (CAB), a high genetic barrier drug resistance and is used formulations for treatment long-acting pre-exposure prophylaxis. We examined whether observed DTG would emerge vitro with CAB. HIV-1IIIB was cultured paired experiments continuous (300 nM) CAB initiated 2 h or 24 after...
Aspergillus fumigatus, an environmental mold, causes life-threatening infections. Studies on the phylogenetic structure of human clinical A. fumigatus isolates are limited. Here, we performed whole genome sequencing 24 collected from 18 patients in U.S. healthcare facilities California. Single-nucleotide polymorphism (SNP) differences between patient ranged 187 to 70 829 SNPs. For five with multiple isolates, calculated within-host diversities. Three had a diversity that 4 10 SNPs and two 2...
Abstract Background Invasive mold infections (IMI) such as aspergillosis and mucormycosis are often fatal among immunocompromised patients cause high-profile outbreaks. Public health surveillance for IMI is challenging; most epidemiologic studies limited to transplant cancer at greatest risk of IMI. The established Mycoses Study Group (MSG) case definition useful clinical trials but lacks sensitivity. To address these challenges, we created within the Georgia Emerging Infections Program....
Abstract Poster session 1, September 21, 2022, 12:30 PM - 1:30 Objective The epidemic of antifungal-resistant dermatophytosis in India has been reported. These infections are associated with severe morbidity, resistance to oral itraconazole and terbinafine, the widespread misuse topical steroids. Trichophyton indotineae emerged as predominant causative agent. In this study, we investigated 162 from eight Indian states using genomic sequencing. primary objective was determine whether a clonal...