A5039097955- Optical Network Technologies
- Advanced Photonic Communication Systems
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Photonic and Optical Devices
- Respiratory viral infections research
- Antibiotics Pharmacokinetics and Efficacy
- Wireless Signal Modulation Classification
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced Optical Network Technologies
- Neural Networks and Reservoir Computing
- Pharmaceutical studies and practices
- Neonatal and Maternal Infections
- Optical Wireless Communication Technologies
- Infective Endocarditis Diagnosis and Management
- Laser Material Processing Techniques
- Bacterial Identification and Susceptibility Testing
- Advanced Fiber Laser Technologies
- Semiconductor Lasers and Optical Devices
- Otolaryngology and Infectious Diseases
- Advanced Fiber Optic Sensors
- Immunodeficiency and Autoimmune Disorders
- Advanced Surface Polishing Techniques
- PAPR reduction in OFDM
Fudan University
2020-2025
Shanghai Micro Satellite Engineering Center
2022-2025
Centers for Disease Control and Prevention
2013-2024
National Center for Immunization and Respiratory Diseases
2009-2024
China Earthquake Administration
2020-2024
United States Department of Health and Human Services
2016-2020
Sinopec (China)
2016
University of Science and Technology of China
2015
First People's Hospital of Foshan
2014
North China Electric Power University
2013
ABSTRACT β-Lactam antibiotics are the drugs of choice to treat pneumococcal infections. The spread β-lactam-resistant pneumococci is a major concern in choosing an effective therapy for patients. Systematically tracking β-lactam resistance could benefit disease surveillance. Here we developed classification system which isolate assigned “PBP type” based on sequence signatures transpeptidase domains (TPDs) three critical penicillin-binding proteins (PBPs), PBP1a, PBP2b, and PBP2x. We...
We performed culture-based and PCR-based tests for pneumococcal identification serotyping from carriage specimens collected in rural urban Kenya. Nasopharyngeal 237 healthy children <5 years old (C-NPs) combined nasopharyngeal/oropharyngeal 158 adults (A-NP/OPs, 118 HIV-positive) were assessed using isolation (following broth culture enrichment) with Quellung-based serotyping, real-time lytA-PCR, conventional multiplexed PCR-serotyping (cmPCR). Culture-based testing C-NPs, HIV-positive...
ABSTRACT Group A streptococci (GAS) are genetically diverse. Determination of strain features can reveal associations with disease and resistance assist in vaccine formulation. We employed whole-genome sequence (WGS)-based characterization 1,454 invasive GAS isolates recovered 2015 by Active Bacterial Core Surveillance performed conventional antimicrobial susceptibility testing. Predictions were made for genotype, carbohydrate, resistance, surface proteins (M family, fibronectin binding, T,...
Abstract Background Group B Streptococcus (GBS) is a leading cause of neonatal sepsis and meningitis an important invasive infections in pregnant nonpregnant adults. Vaccines targeting capsule polysaccharides common proteins are under development. Methods Using whole genome sequencing, validated bioinformatics pipeline, targeted antimicrobial susceptibility testing, we characterized 6340 GBS isolates recovered during 2015–2017 through population-based Active Bacterial Core surveillance...
Seamless fiber-terahertz integrated communication has emerged as a promising technology in the special field of 6G, including mobile fronthaul and wireless bridges. Electronic terahertz systems have advantages high-level integration, small form factors, potentially low costs, but their drawbacks are bandwidths high harmonic interference levels. In this paper, an end-to-end learning-based waveform-to-waveform automatic equalization framework (W2WAEF) is proposed to overcome above shortcomings...
In the upcoming 6G, integrated sensing and communication (ISAC) system in millimeter wave (MMW) band will have a vital role numerous application scenarios, enhancing convenience of our lives. The photonic-based MMW ISAC can exploit broad bandwidth photonic devices, significantly improving performance. Furthermore, use devices enables seamless integration with fiber-wireless network. this paper, we proposed simple-structured W-band system, incorporating optical fiber transmission into system....
ABSTRACT The group A Streptococcus (GAS) sof gene encodes the serum opacity factor protein, which is capable of opacifying mammalian sera and binding at least two host proteins, fibronectin fibrinogen. exists in approximately 50% clinical isolates, there a classical association so-called nephritogenic strains with factor-positive phenotype. In both type emm49 strain emm12 strain, sequences upstream 5′ end downstream putative terminator were determined to be nearly identical region M 1 genome...
Geographic and interseasonal heterogeneity of pharyngeal group A streptococcal (GAS) genotypes (emm types) is poorly characterized. We evaluated emm type subtype distribution among pediatric pharyngitis isolates obtained from 9 sites in the United States during 2000-2001 (year 1) 10 1 site Canada 2001-2002 2). The 7 predominant types were same both years, although their order changed. 12, 1, 28 accounted for 49.2% year isolates, 4 47.1% 2 isolates; 6 72.1% 69.4% 2. From to 2, proportions 12...
According to population-based invasive pneumococcal surveillance in the United States during 2007, 898 (26%) of 3,511 isolates were penicillin nonsusceptible. Non-7-valent conjugate vaccine (PCV7) serotypes other than 19A accounted for 40% these penicillin-nonsusceptible isolates; these, 15A (11%), 23A (8%), 35B and 6C (5%) most common (cumulatively 32% isolates). Each except represented a single serotype clonal complex combination that predated introduction PCV7. We evaluated genetic...
Pharyngeal group A streptococcal (GAS) emm type surveillance enhances understanding of the epidemiology pharyngitis and invasive GAS disease formulation multivalent type-specific vaccines. In addition, such provides pre-GAS vaccine baseline data. We assessed geographic temporal trends in emm-type distribution among pediatric pharyngeal isolates collected systematically United States Canada from 2000 to 2007.We approximately 100 acute each 13 widely scattered sites (10 3 Canada) annually for...
Genomic sequence-based deduction of antibiotic minimum inhibitory concentration (MIC) has great potential to enhance the speed and sensitivity antimicrobial susceptibility testing. We previously developed a penicillin-binding protein (PBP) typing system two methods (Random Forest (RF) Mode MIC (MM)) that accurately predicted β-lactam MICs for pneumococcal isolates carrying characterized PBP sequence type (phenotypic known at least one isolate this type). This study evaluates prediction...
Aside from ambient light noise, shot and linear/nonlinear effects, strong low-frequency noise (LFN) severely affects the signal quality in LED-based visible communication (VLC) systems, which hinders implementation of data-driven end-to-end (E2E) deep learning approaches real LED-VLC systems. We present a learning-based autoencoder to deal with this challenge. A novel modeling strategy is proposed bypass influence LFN other low signal-to-noise ratio data when training channel model our E2E...
From 2015-2018 to 2019‒2021, hypertoxigenic M1UK lineage among invasive group A Streptococcus increased in the United States (1.7%, 21/1,230 11%, 65/603; p<0.001). was observed 9 of 10 states, concentrated Georgia (n = 41), Tennessee 13), and New York 13). Genomic cluster analysis indicated recent expansions.
Emerging services such as 8K/16K high-quality video streaming, virtual reality/augmented reality, beyond-5G mobile Internet, and edge computing are driving the need for even higher speed, capacity, flexibility in optical access networks. Coherent passive networks (CPONs) have garnered significant attention recent years due to their superior receiver sensitivity high 100G speeds beyond. Research interest has surged flexible, multi-dimensional multiplexing schemes that go beyond traditional...
Theseven-valent pneumococcal conjugated polysaccharide vaccine PC7V was licensed for use among children in 2000. Since 90 serotypes of pneumococci exist, an increase nonvaccine could occur through immune selection capsular type switching. Eleven hundred sixty-eight invasive isolates (24 serotypes), recovered primarily from pediatric patients (855 = 73%) and 22 reference strains known multilocus sequence types (STs) were subjected to macrorestriction profiling (pulsed-field gel...
Using sequence analysis to detect variation within the hypervariable M protein N terminus, we found 41 emm types encompassing 81 subtypes, among 1064 consecutive invasive group A streptococcus isolates from a recent multistate, population-based surveillance. Seventeen of 30 represented by multiple displayed subtypes. Most subtypes differed reference strain sequences as result single base substitutions or other alterations likely be stably inherited. The Centers for Disease Control and...
Beta-hemolytic group C and G streptococci cause a considerable invasive disease burden sometimes outbreaks. Little is known about the critical epidemiologic parameter of genetic relatedness between isolates. We determined emm types 334 Streptococcus dysgalactiae subsp. equisimilis isolates, attempted typing 5 canis isolates from recent population-based surveillance for Thirty-four were observed, including one S. canis. formulated multilocus sequence (MLST) primers with six seven loci...
We used whole-genome sequencing to characterize 199 nonvaccine serotype 35B pneumococcal strains that caused invasive disease (IPD) in the United States during 2015-2016 and related these findings previous IPD data obtained by Active Bacterial Core surveillance. Penicillin-nonsusceptible increased post-pneumococcal 7-valent conjugate vaccine years (2001-2009) further after implementation of 13-valent 2010. This increase was primarily 35B/sequence type (ST) 558 lineage. 35B/ST558 9V/ST156...
Inverse design has been widely studied as an efficient method to reduce footprint and improve performance for integrated silicon photonic (SiP) devices. In this study, we have used inverse develop a series of ultra-compact dual-band wavelength demultiplexing power splitters (WDPSs) that can simultaneously perform both 1:1 optical splitting. These WDPSs could facilitate the potential coexistence passive networks (PONs). The is performed on standard silicon-on-insulator (SOI) platform using,...
High-speed optical transmission systems suffer from severe intersymbol-interference (ISI) caused by limited bandwidth. To address this challenge, previous studies on bandwidth signals have explored the use of a post filter after full-response equalization to whiten colored noise and enhance system performance. However, requires additional training or scanning processes appropriate coefficient values, which introduces overhead time consumption. A low-complexity duobinary neural network...
Photonic millimeter-wave communication systems are promising for high-capacity, high-speed wireless networks, and their production is driven by the growing demand from data-intensive applications. However, challenges such as inter-symbol interferences (ISIs), inter-band (IBIs), symbol timing offsets (STOs), nonlinearity impairments exist, especially in non-orthogonal multiband configurations. This paper proposes demonstrates neural network-based waveform-to-symbol converter (NNWSC) a...
Invasive pneumococcal disease (IPD) has greatly decreased since implementation in the U.S. of 7 valent conjugate vaccine (PCV7) 2000 and 13 (PCV13) 2010. We used whole genome sequencing (WGS) to predict phenotypic traits (serotypes, antimicrobial phenotypes, pilus determinants) determine multilocus genotypes from 5334 isolates (~90% cases) recovered during 2015-2016 through Active Bacterial Core surveillance. identified 44 serotypes; 26 accounted for 98% isolates. PCV13 serotypes (inclusive...
Bacterial mutations predisposing pneumococcus to causing meningitis, a more severe form of invasive pneumococcal disease (IPD), are largely unknown. Knowledge such may improve our understanding pathogenesis and inform preventive strategies. Here we report pbp1b gene mutation (pbp1bA641C N214T change in PBP1b transglycosylase domain) that is associated with meningitis an exploratory cohort IPD patients (n = 2054, p 6.8 × 10-6), independent confirmatory 2518, 2.3 combined analysis 4572, 3.0...
Background Streptococcus pyogenes is a major cause of severe, invasive infections in humans. The bacterial pathogen harbors wide array virulence factors and exhibits high genomic diversity. Rapid changes circulating strains community are common. Understanding the current prevalence dynamics S. lineages could inform vaccine development disease control strategies. Methods We used whole-genome sequencing (WGS) to characterize all isolates obtained through Center for Disease Control Prevention's...