Maria Garcia Quesada
A5028773306- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Bacterial Infections and Vaccines
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Tuberculosis Research and Epidemiology
- Viral gastroenteritis research and epidemiology
- Immunodeficiency and Autoimmune Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 epidemiological studies
- Long-Term Effects of COVID-19
- Vaccine Coverage and Hesitancy
- Child Nutrition and Water Access
- Tracheal and airway disorders
- Antimicrobial Resistance in Staphylococcus
- Escherichia coli research studies
- COVID-19 and Mental Health
- Neural and Behavioral Psychology Studies
- Face Recognition and Perception
- Evolutionary Psychology and Human Behavior
Johns Hopkins University
2020-2025
Emory University
2023-2024
University of Geneva
2017
Pneumococcal conjugate vaccine (PCV) introduction has reduced pneumococcal meningitis incidence. The Serotype Replacement and Distribution Estimation (PSERENADE) project described the serotype distribution of remaining in countries using PCV10/13 for least 5–7 years with primary series uptake above 70%. was estimated a multinomial Dirichlet regression model, stratified by PCV product age. In PCV10-using sites (N = 8; cases 1141), PCV10 types caused 5% <5 age 15% among ≥5 years; top...
Serotype-specific surveillance for invasive pneumococcal disease (IPD) is essential assessing the impact of 10- and 13-valent conjugate vaccines (PCV10/13). The Pneumococcal Serotype Replacement Distribution Estimation (PSERENADE) project aimed to evaluate global evidence estimate PCV10/13 by age, product, schedule, syndrome. Here we systematically characterize summarize landscape routine serotype-specific IPD in PCV10/13-using countries describe subset that are included PSERENADE. Of 138...
Pneumococcal conjugate vaccines (PCVs) that are ten-valent (PCV10) and 13-valent (PCV13) became available in 2010. We evaluated their global impact on invasive pneumococcal disease (IPD) incidence all ages. Serotype-specific IPD cases population denominators were obtained directly from surveillance sites using PCV10 or PCV13 national immunisation programmes with a primary series uptake of at least 50%. Annual rate ratios (IRRs) estimated comparing the before any PCV each year post-PCV10...
Few studies have prospectively assessed SARS-CoV-2 community infection in children aged 0 to 4 years. Information about incidence and clinical virological features young could help guide prevention mitigation strategies.To assess incidence, features, symptoms a prospective household cohort compare viral load by age group, symptoms, lineage children, older adults.This study enrolled 690 participants from 175 Maryland households with 1 or more years between November 24, 2020, October 15, 2021....
Widespread use of pneumococcal conjugate vaccines (PCVs) has reduced vaccine-type invasive disease (IPD). We describe the serotype distribution IPD after extensive ten-valent PCV (PCV10; Synflorix, GSK) and 13-valent (PCV13; Prevenar 13, Pfizer) globally. data were obtained from surveillance sites participating in WHO-commissioned Pneumococcal Serotype Replacement Distribution Estimation (PSERENADE) project that exclusively used PCV10 or PCV13 (hereafter sites, respectively) their national...
Background. SARS-CoV-2 infections are frequently milder in children than adults, suggesting that immune responses may vary with age. However, information is limited regarding young children.
Both affective states and personality traits shape how we perceive the social world interpret emotions. The literature on priming has mostly focused brief influences of emotional stimuli perceptual cognitive processes. Yet this approach does not fully capture more dynamic processes at root states, with such lingering beyond duration inducing external stimuli. Our goal was to put in perspective three different types (induced sustained mood as depression anxiety) investigate they may interact...
Attributing infectious causes of diarrhea is critical to inform treatment and burden estimates. The attributable fraction (AF) approach based on the association between pathogen quantity has been frequently used but may underestimate incidence. We leveraged data from multisite birth-cohort Malnutrition Enteric Disease (MAL-ED) Study, where diarrheal non-diarrheal stools were collected 1,715 children 0-2 years. compared attribution using a longitudinal AF (LAF) method that considers temporal...
Streptococcus pneumoniae serotype 1 (ST1) was an important cause of invasive pneumococcal disease (IPD) globally before the introduction conjugate vaccines (PCVs) containing ST1 antigen. The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) project gathered IPD surveillance data from sites aimed to estimate PCV10/13 impact on incidence. We estimated incidence rate ratios (IRRs) comparing pre-PCV10/13 period each post-PCV10/13 year by site using a Bayesian multi-level,...
Background: Widespread use of pneumococcal conjugate vaccines (PCVs) has reduced vaccine-type invasive disease (IPD). We describe the serotype distribution IPD after extensive PCV10 and PCV13 globally.Methods: data were obtained from surveillance sites globally that exclusively used or in their national immunization program had primary series uptake ≥70%. Serotype was estimated for cases occurring ≥5 years post-introduction (i.e., mature PCV10/13 period) using multinomial Dirichlet...
Background: Approximately ten years after seven-valent pneumococcal conjugate vaccine (PCV7) was licensed, PCV10 and PCV13 became available. We evaluated their impacts globally on invasive disease (IPD) incidence in all ages. Methods: Serotype-specific IPD cases population denominators were obtained directly from surveillance sites. Annual rate ratios (IRRs) estimated comparing the pre-any PCV to each post-PCV10/13 year using Bayesian multi-level, mixed effects Poisson regressions, by site...
Abstract Background During the coronavirus disease 2019 (COVID-19) pandemic, human parainfluenza type 3 (HPIV-3) and respiratory syncytial virus (RSV) circulation increased as nonpharmaceutical interventions were relaxed. Using data from 175 households (n = 690 members) followed between November 2020 October 2021, we characterized HPIV-3 RSV epidemiology in children aged 0–4 years their households. Methods Households with ≥1 child enrolled; members collected weekly nasal swabs (NS)...
Abstract Background Pneumococcal conjugate vaccines (PCV) have reduced invasive pneumococcal disease (IPD) (see other PSERENADE abstract), of which &gt; 70% was vaccine-type pre-PCV. We described the serotype (ST) distribution remaining IPD in countries with mature infant PCV10/13 programs. Methods ST data were obtained directly from surveillance sites, supplemented published literature. Mature programs defined as exclusive use PCV10 or PCV13 for at least 5-7 years (depended on if prior...
Clinical and subclinical Shigella infections among children living in low- middle-income countries (LMICs) have been associated with long-term adverse effects such as impaired linear growth. The mechanism for the impact of has theorized to occur through contributions environmental enteropathy (EE). While previously biomarkers EE at time infection, we evaluated whether this was sustained after infections, which would support being on A prospective birth cohort study 1,715 8 different LMICs...
Abstract SARS-CoV-2 infections are frequently milder in children than adults, suggesting that immune responses may vary with age. However, information is limited regarding young children. We compared Receptor Binding Domain binding antibody (RBDAb) and neutralizing (neutAb) aged 0-4 years, 5-17 adults 18-62 years a household study. Among 55 participants seropositive at enrollment, had >10-fold higher RBDAb titers (373 vs.35, P <0.0001), the highest 11/12 households adults. Children...
The uptake of COVID-19 vaccines remains low despite their high effectiveness. Epidemic models that represent decision-making psychology can provide insight into the potential impact vaccine promotion interventions in context pandemic. We coupled a network-based mathematical model SARS-CoV-2 transmission Georgia, USA with social-psychological vaccination which side effects, post-vaccination infections, and other unidentified community-level factors could "nudge" individuals towards resistance...
Estimates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence in young children and risk factors for seropositivity are scarce. Using data from a prospective cohort study households during the pre-coronavirus disease 2019 (COVID-19) vaccine period, we estimated SARS-CoV-2 by age evaluated seropositivity. The Epidemiology Response Children (SEARCh) enrolled 175 Maryland (690 participants) with ≥1 child aged 0-4 years November 2020-March 2021; individuals vaccinated...