Idrissa Diawara
A5011974999- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Streptococcal Infections and Treatments
- Antibiotic Use and Resistance
- Tuberculosis Research and Epidemiology
- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Infective Endocarditis Diagnosis and Management
- Nosocomial Infections in ICU
- Vibrio bacteria research studies
- Bacteriophages and microbial interactions
- Diagnosis and treatment of tuberculosis
- Antibiotics Pharmacokinetics and Efficacy
- Viral gastroenteritis research and epidemiology
- Neonatal and Maternal Infections
- Escherichia coli research studies
- Essential Oils and Antimicrobial Activity
- Pharmacological Effects of Medicinal Plants
- Viral Infections and Outbreaks Research
- Poxvirus research and outbreaks
Université Mohammed VI des Sciences de la Santé
2019-2024
University of Health Science
2020-2024
University of Health Sciences
2020-2024
University of Hassan II Casablanca
2015-2023
Centre Hospitalier Universitaire Ibn Rochd
2015-2023
Laboratoire National de Référence
2022
Association Marocaine Pour la Recherche Développement
2014
Sidi Mohamed Ben Abdellah University
2014
Invasive pneumococcal disease remains an important health priority owing to increasing incidence caused by pneumococci expressing non-vaccine serotypes. We previously defined 621 Global Pneumococcal Sequence Clusters (GPSCs) analysing 20 027 isolates collected worldwide and from published genomic data. In this study, we aimed investigate the lineages behind predominant serotypes, mechanism of serotype replacement in disease, as well major contributing invasive post-vaccine era their...
Pneumococcal conjugate vaccine (PCV) introduction has reduced pneumococcal meningitis incidence. The Serotype Replacement and Distribution Estimation (PSERENADE) project described the serotype distribution of remaining in countries using PCV10/13 for least 5–7 years with primary series uptake above 70%. was estimated a multinomial Dirichlet regression model, stratified by PCV product age. In PCV10-using sites (N = 8; cases 1141), PCV10 types caused 5% <5 age 15% among ≥5 years; top...
Pneumococcal conjugate vaccines (PCVs) that are ten-valent (PCV10) and 13-valent (PCV13) became available in 2010. We evaluated their global impact on invasive pneumococcal disease (IPD) incidence all ages. Serotype-specific IPD cases population denominators were obtained directly from surveillance sites using PCV10 or PCV13 national immunisation programmes with a primary series uptake of at least 50%. Annual rate ratios (IRRs) estimated comparing the before any PCV each year post-PCV10...
Extended-spectrum β-lactamases producing Escherichia coli (ESBL-EC) lend resistance to most β-lactam antibiotics. Because of limited treatment options, ESBL-EC infections are generally more difficult treat, leading higher hospital costs, reduced rates microbiological and clinical responses, a threat the patient’s life. This study aimed determine antibiotic pattern isolated from patients with urinary tract infection in Morocco. retrospective laboratory-based was conducted at Cheikh Khalifa...
Widespread use of pneumococcal conjugate vaccines (PCVs) has reduced vaccine-type invasive disease (IPD). We describe the serotype distribution IPD after extensive ten-valent PCV (PCV10; Synflorix, GSK) and 13-valent (PCV13; Prevenar 13, Pfizer) globally. data were obtained from surveillance sites participating in WHO-commissioned Pneumococcal Serotype Replacement Distribution Estimation (PSERENADE) project that exclusively used PCV10 or PCV13 (hereafter sites, respectively) their national...
The purpose of this study was to compare the incidence rate invasive pneumococcal disease, rates antibiotic resistance and serotype distribution among children ≤5 years old before after PCVs introduction in Casablanca, Morocco.This conducted at Ibn Rochd University Hospital Centre Casablanca during two periods encompassing pre-and post-implementation PCVs, respectively from January 2007 October 2010 2011 December 2014. All non-duplicate S. pneumoniae isolates recovered were included.There...
Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition gene cassettes. Both occurred in otherwise contrasting histories antibiotic-resistant S. lineages PMEN3 PMEN9. A single clade spread globally, evading vaccine-induced immunity frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. repeatedly integrated Tn 916 -type 1207.1 elements,...
We describe cases with monkeypox virus (MPXV) Clade Ib in Burundi from their first detection July until 20 August 2024. Testing 442 people vesicular lesions confirmed 170 (98 male; 72 female), 82 (48%) being < 15 years old. Differential diagnosis of the 30 individuals testing MPXV negative revealed chickenpox 20. Cases occurred 26 49 health districts, but mostly Bujumbura Nord (88/170; 67%). Case-derived genetic sequences and South-Kivu (Democratic Republic Congo), clustered together...
Pneumococcal disease outbreaks of vaccine preventable serotype 4 sequence type (ST)801 in shipyards have been reported several countries. We aimed to use genomics establish any international links between them.Sequence data from ST801-related outbreak isolates Norway (n = 17), Finland 11) and Northern Ireland 2) were combined with invasive pneumococcal surveillance the respective countries, genomes an collection 41 > 40,000), totalling 106 genomes. Raw mapped recombination excluded before...
Pertussis, a vaccine preventable disease, is still responsible of significant morbidity and mortality around the world, mostly in newborns. The aim present study was (1) to introduce pertussis surveillance major pediatric hospital Casablanca (2) analyze prevalence among children under 14 years age their entourage Casablanca, Morocco. This prospective non-case controlled study, including suspected Pertussis admitted at Abderrahim Harouchi Pediatric Hospital from January 2013 June 2015....
Here, we report the draft genome sequences of six severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains. SARS-CoV-2 is responsible for COVID-19 pandemic, which started at end 2019 in Wuhan, China. The isolates were obtained from nasopharyngeal swabs Moroccan patients with COVID-19. Mutation analysis revealed presence spike D614G mutation all genomes, widely present several genomes around world.
Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide, especially among children the elderly. The ability to effectively treat pneumococcal infection has been compromised due acquisition antibiotic resistance, particularly β-lactam drugs. This study aimed describe prevalence molecular evolution penicillin non-susceptible S. (PNSP) isolated from invasive diseases before after conjugate vaccine implementation in Casablanca, Morocco. Isolates were obtained Microbiology...
Introduction: Acute bacterial meningitis is one of the most severe infectious diseases. Rapid, accurate, and inexpensive diagnosis crucial for patient management. This study describes a duplex real-time (RT) PCR assay detection Neisseria meningitidis Streptococcus pneumoniae in cerebrospinal fluid (CSF) using SYBR Green-based RT-PCR method coupled with melting curve analysis. Methodology: We used analysis to detect S. N. CSF samples. The sensitivity, specificity, limit were determined. gold...
Background: Widespread use of pneumococcal conjugate vaccines (PCVs) has reduced vaccine-type invasive disease (IPD). We describe the serotype distribution IPD after extensive PCV10 and PCV13 globally.Methods: data were obtained from surveillance sites globally that exclusively used or in their national immunization program had primary series uptake ≥70%. Serotype was estimated for cases occurring ≥5 years post-introduction (i.e., mature PCV10/13 period) using multinomial Dirichlet...
Background: Approximately ten years after seven-valent pneumococcal conjugate vaccine (PCV7) was licensed, PCV10 and PCV13 became available. We evaluated their impacts globally on invasive disease (IPD) incidence in all ages. Methods: Serotype-specific IPD cases population denominators were obtained directly from surveillance sites. Annual rate ratios (IRRs) estimated comparing the pre-any PCV to each post-PCV10/13 year using Bayesian multi-level, mixed effects Poisson regressions, by site...
Streptococcus pneumoniae, a major contributor to global morbidity and mortality, disproportionately affects children, the elderly, immunocompromised individuals. Despite vaccination efforts, challenge of serotype replacement highlights ongoing struggle against invasive pneumococcal diseases (IPD) in Morocco, emphasizing need for updated public health strategies vaccine efficacy assessments.
Simple parapneumonic effusion is a pleural associated with lung infection (i.e., pneumonia). Streptococcus pneumoniae remains the most common pathogen causing effusions. In Morocco, pneumococcal conjugate vaccine 13-valent (PCV13) was introduced in national immunization program October 2010 2 + 1 schedule for prevention of disease, and replaced by PCV10 July 2012 same schedule. We report case effusions caused S. serotype 19A child immunized 3 doses PCV13. This 2.5 years old previously...
This study aimed to investigate the nature of amino acid motifs found in PBPs Streptococcus pneumoniae isolates invasive diseases from pediatric patients at Casablanca, Morocco. Five penicillin-susceptible (PSSP), ten penicillin-intermediate (PISP), and fifteen penicillin-resistant S. (PRSP) were studied by PCR–RFLP DNA sequencing pbp1a, − 2b, 2x genes. There no changes conserved PBP1a, PBP2b PBP2x for PSSP strains. Substitution close PBP1a all PRSP six/five PISP. Analysis showed that but...
Abstract Objectives We reported tet(S/M) in Streptococcus pneumoniae and investigated its temporal spread relation to nationwide clinical interventions. Methods whole-genome sequenced 12 254 pneumococcal isolates from 29 countries on an Illumina HiSeq sequencer. Serotype, multilocus ST antibiotic resistance were inferred genomes. An SNP tree was built using Gubbins. Temporal reconstructed a birth–death model. Results identified 131 none carried other known tet genes. Tetracycline...
Abstract This study determined the chemical composition of Cinnamomum verum J.Presl, Cistus ladaniferus L., Laurus nobilis L. , Senecio anteuphorbuim, Boswellia serrata Roxb. ex Colebr. and Schinus molle essential oils (EOs) by gas chromatography‐mass spectrometry. Moreover, six EOs were screened in order to reveal their antibacterial antioxidant activities. They initially tested against pathogenic bacteria: Staphylococcus aureus (MRSA: methicillin‐resistant ), Escherichia coli (ESBL:...