Michele Nurse-Lucas
A5018229514- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Antibiotic Resistance in Bacteria
- Influenza Virus Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antibiotics Pharmacokinetics and Efficacy
University of the West Indies
2016-2024
University of the West Indies System
2021
Invasive pneumococcal disease remains an important health priority owing to increasing incidence caused by pneumococci expressing non-vaccine serotypes. We previously defined 621 Global Pneumococcal Sequence Clusters (GPSCs) analysing 20 027 isolates collected worldwide and from published genomic data. In this study, we aimed investigate the lineages behind predominant serotypes, mechanism of serotype replacement in disease, as well major contributing invasive post-vaccine era their...
Abstract Streptococcus pneumoniae is a leading cause of pneumonia and meningitis worldwide. Many different serotypes co-circulate endemically in any one location 1,2 . The extent mechanisms spread vaccine-driven changes fitness antimicrobial resistance remain largely unquantified. Here using geolocated genome sequences from South Africa ( n = 6,910, collected 2000 to 2014), we developed models reconstruct spread, pairing detailed human mobility data genomic data. Separately, estimated the...
Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition gene cassettes. Both occurred in otherwise contrasting histories antibiotic-resistant S. lineages PMEN3 PMEN9. A single clade spread globally, evading vaccine-induced immunity frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. repeatedly integrated Tn 916 -type 1207.1 elements,...
Pneumococcal disease outbreaks of vaccine preventable serotype 4 sequence type (ST)801 in shipyards have been reported several countries. We aimed to use genomics establish any international links between them.Sequence data from ST801-related outbreak isolates Norway (n = 17), Finland 11) and Northern Ireland 2) were combined with invasive pneumococcal surveillance the respective countries, genomes an collection 41 > 40,000), totalling 106 genomes. Raw mapped recombination excluded before...
There are currently 94 known pneumococcal capsular polysaccharide serotypes and their prevalence differs by geographic region the period studied. Streptococcus pneumoniae infections have been diagnosed clinically in Trinidad Tobago other Caribbean countries, however data on serotype sequence type distributions this country limited. The objective of study was to determine multilocus types (MLSTs) invasive non-invasive isolates from Tobago.Ninety-eight several regional hospitals were analyzed...
In Latin America and the Caribbean, pneumococcal infections are estimated to account for 12 000–18 000 deaths, 327 pneumonia cases, 4000 meningitis cases 1229 sepsis each year in children under five years old. Pneumococcal antimicrobial resistance has evolved into a worldwide health problem last few decades. This study aimed determine susceptibility profiles of isolates collected Trinidad Tobago their associated genetic determinants. Whole-genome sequences were obtained from 98 recovered at...