A5029335611- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Enterobacteriaceae and Cronobacter Research
- Bacterial Identification and Susceptibility Testing
- Vibrio bacteria research studies
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical and Antibiotic Environmental Impacts
- Infections and bacterial resistance
- Streptococcal Infections and Treatments
- Bacterial Infections and Vaccines
- Neonatal and Maternal Infections
- Antibiotic Use and Resistance
- Plant Pathogenic Bacteria Studies
- Infective Endocarditis Diagnosis and Management
- Escherichia coli research studies
- Salmonella and Campylobacter epidemiology
- Respiratory viral infections research
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Antifungal resistance and susceptibility
- Bacterial Genetics and Biotechnology
- Neonatal Health and Biochemistry
- Cystic Fibrosis Research Advances
Administración Nacional de Laboratorios e Institutos de Salud
2016-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2025
Centro Científico Tecnológico - San Juan
2016-2023
Ministerio de Salud
2011
Virginia Commonwealth University
2007
Invasive pneumococcal disease remains an important health priority owing to increasing incidence caused by pneumococci expressing non-vaccine serotypes. We previously defined 621 Global Pneumococcal Sequence Clusters (GPSCs) analysing 20 027 isolates collected worldwide and from published genomic data. In this study, we aimed investigate the lineages behind predominant serotypes, mechanism of serotype replacement in disease, as well major contributing invasive post-vaccine era their...
We have characterized nine mcr-1-harboring plasmids from clinical Escherichia coli isolates previously described in Argentina and Canada. Three of these carried a mcr-1-variant called here mcr-1.5. All E. were not clonally related recovered different years locations. However, their showed high identity among them to others other countries, which strongly suggests that this plasmid-type is playing an important role spreading mechanism resistance polymyxins.
Background. The global spread of carbapenemase-producing Enterobacterales has become an epidemiological risk for healthcare systems by limiting available antimicrobial treatments. COVID-19 pandemic worsened this scenario, prompting the emergence extremely resistant microorganisms. Methods. Between March 2020 and September 2021, NRL confirmed 82 clinical isolates harboring a combination blaKPC MBL genes. Molecular typing was analyzed PFGE MLST. Modified double-disk synergy (MDDS) tests were...
The antimicrobial peptide P6.2 was previously de novo designed as an alpha helix cationic amphipathic molecule. In previous work, we have shown that this displayed significant activity against both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) bacteria. However, while lacked biofilm-inhibiting properties the P. aeruginosa strain PA01, it anti-inflammatory effects in a murine acute lung infection model challenged with pathogen. its possible synergy meropenem...
Phenotypic and genotypic characterization of 133 isolates Neisseria meningitidis obtained from meningococcal disease cases in Argentina during 2010 were performed by the National Reference Laboratory as part a project coordinated PAHO within SIREVA II network. Serogroup, serotype, serosubtype MLST performed. Minimum Inhibitory Concentration to penicillin, ampicillin, ceftriaxone, rifampin, chloramphenicol, tetracycline ciprofloxacin determined interpreted according CLSI guidelines. Almost...
Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition gene cassettes. Both occurred in otherwise contrasting histories antibiotic-resistant S. lineages PMEN3 PMEN9. A single clade spread globally, evading vaccine-induced immunity frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. repeatedly integrated Tn 916 -type 1207.1 elements,...
The aim of this study was to characterize the first 14 optrA-carrying linezolid resistant E. faecalis clinical isolates recovered in seven Argentinian hospitals between 2016 and 2021. epidemiology optrA genetic context were determined. phenotypically genotypically characterized. Susceptibility 13 antimicrobial agents performed; clonal relationship assessed by pulsed field gel electrophoresis (PFGE) multilocus sequence typing (MLST). Data provided whole-genome sequencing used for...
In Argentina, NDM metallo-β-lactamase was first reported in 2013. By now, it has disseminated throughout the country diverse Gram negative bacteria. Here, we report case of a paediatric patient that underwent 1-year hospitalisation due to erythrodermic psoriasis 2014 and received multiple antimicrobial treatments. During his stay, five isolates were obtained from rectal swabs (rs) or blood culture (bc) suspicious carbapenemase production: K. quasipneumoniae subsp. (rs), Citrobacter freundii...
By studying the beta-lactamase content of several Acinetobacter spp. isolates from Argentina, producing expanded-spectrum beta-lactamases (ESBL) VEB-1a or PER-2, a novel Ambler class A gene was identified. It encoded narrow-spectrum SCO-1, whose activity inhibited by clavulanic acid. SCO-1 hydrolyzes penicillins at high level and cephalosporins carbapenems very low level. beta-Lactamase identified unrelated VEB-1a-positive PER-2-positive recovered three hospitals. The bla(SCO-1) apparently...
Introduction: The HTR2C gene is an important candidate in pharmacogenetic studies of antipsychotic-induced weight gain (AIWG). However, inconsistent results have been obtained. present study investigated the association between -759C>T, functional polymorphism receptor, and AIWG. Methods: A prospective cohort 48 female inpatients with schizophrenia related illness treated according to normal clinical practice second generation antipsychotics (SGAs) risperidone, clozapine, quetiapine,...