A5078268367- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Migration, Identity, and Health
- New Caledonia Indigenous Studies
- Island Studies and Pacific Affairs
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Multiculturalism, Politics, Migration, Gender
- Chemical synthesis and alkaloids
- French Urban and Social Studies
- Fungal Biology and Applications
- Asymmetric Hydrogenation and Catalysis
- Canadian Identity and History
- Synthetic Organic Chemistry Methods
- Intimate Partner and Family Violence
- Synthesis and Biological Activity
- Plant Pathogens and Fungal Diseases
- Mycorrhizal Fungi and Plant Interactions
- Bat Biology and Ecology Studies
- HIV/AIDS Impact and Responses
- African Studies and Ethnography
- Plant-Microbe Interactions and Immunity
- Cultural Identity and Heritage
- Child Abuse and Trauma
- Adolescent Sexual and Reproductive Health
University of Minnesota
2014-2025
Comisión de Investigaciones Científicas
2025
Minot State University
2021
Centre National de la Recherche Scientifique
2010-2020
Université de Bourgogne
2006-2020
Institut de Chimie
2010-2020
Inserm
2003-2016
Centre de recherche en Epidémiologie et Santé des Populations
2009-2016
Hôpital Paul-Brousse
2016
Université Paris 8
2013-2016
Acacia hydaspica R. Parker is known for its medicinal uses in multiple ailments. In this study, we performed bioassay-guided fractionation of cytotoxic compounds from A. and investigated their effects on growth signaling activity prostate breast cancer cell lines. Four active polyphenolic were identified as 7-O-galloyl catechin (GC), (C), methyl gallate (MG), catechin-3-O-gallate (CG). The four inhibited PC-3 a dose-dependent manner, whereas CG MG MDA-MB-231 growth. All tested survival...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Azacyclopropene Derivatives from Dysidea fragilis Collected in PohnpeiChristine E. Salomon, David H. Williams, and D. John FaulknerCite this: J. Nat. Prod. 1995, 58, 9, 1463–1466Publication Date (Print):September 1, 1995Publication History Published online1 July 2004Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/np50123a021https://doi.org/10.1021/np50123a021research-articleACS PublicationsRequest reuse permissionsArticle...
Bifunctional inhibitors were designed and synthesized based on 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)a1 non-nucleoside reverse transcriptase (RT) diketoacid (DKA) integrase (IN) inhibitors. Biochemical studies revealed activity against RT IN at low nanomolar micromolar concentrations, respectively. Exceptionally IC50 values from a cell-based assay achieved along with remarkably high therapeutic indices. Compound 7 was identified as the best compound of series (IC50: 24 nM...
Though traditionally perceived as weapons, antibiotics are also hypothesized to act microbial signals in natural habitats. However, while subinhibitory concentrations of (SICA) known shift bacterial gene expression, specific hypotheses how SICA influence the ecology populations scarce. We explored whether antibiotic 'signals', or SICA, have potential alter nutrient utilization, niche overlap, and competitive species interactions among Streptomyces soil. For nine diverse isolates, we...
Abstract Cryptosporidium is a common, waterborne gastrointestinal parasite that causes diarrheal disease worldwide. Currently there are no effective therapeutics to treat cryptosporidiosis in at-risk populations. Since natural products known source of anti-parasitic compounds, we screened library extracts and pure product compounds isolated from bacteria fungi collected subterranean environments for activity against parvum . Eight structurally related norditerpene lactones the fungus...
The antimicrobial peptide P6.2 was previously de novo designed as an alpha helix cationic amphipathic molecule. In previous work, we have shown that this displayed significant activity against both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) bacteria. However, while lacked biofilm-inhibiting properties the P. aeruginosa strain PA01, it anti-inflammatory effects in a murine acute lung infection model challenged with pathogen. its possible synergy meropenem...
A case-control study on respiratory cancers was conducted in New Caledonia (South Pacific), where a high incidence of malignant pleural mesothelioma had been observed. The disease pattern suggested an environmental exposure to asbestos. first results showed that, some areas, tremolite asbestos derived from local outcroppings used as whitewash (locally named "pö"). All cases diagnosed between 1993 and 1995 (including 15 mesotheliomas, 228 lung cancers, 23 laryngeal cancers) 305 controls were...
Edible mushrooms are an important source of nutraceuticals and for the discovery bioactive metabolites as pharmaceuticals. In this work, OSMAC (One Strain, Many Active Compounds) approach was used to isolate two new compounds (1 2) along with seven known (3-9) from a mycelial culture unique North American edible mushroom Hericium sp. The fruiting body collected in Marine on St. Croix, Minnesota (USA), cultures were grown four different solid liquid media. Extracts screened antimicrobial...
We report on the structure elucidation of arnamial, a new Δ2,4-protoilludane everninate ester from fungus Armillaria mellea, and apoptotic activity arnamial as well cytotoxic structurally related compounds selected human cancer cells. Arnamial showed cytotoxicity against Jurkat T cells, MCF-7 breast adenocarcinoma, CCRF-CEM lymphoblastic leukemia, HCT-116 colorectal carcinoma cells at IC50 = 3.9, 15.4, 8.9, 10.7 μM, respectively, aryl melledonal C (IC50 14.75 μM). [1,2-13C2]Acetate feeding...
Mines and caves are unusual ecosystems containing unique fungi greatly understudied compared to other environments. The Soudan Mine in Tower, MN, an iron ore mine that closed 1963 after operating for 80 years, was sampled explore fungal diversity investigate taxa tolerate heavy metals potential bioprocessing technologies or as sources of bioactive molecules drug discovery possible biocontrol white-nose syndrome (WNS) bats. is 714 m deep, has 18 levels contains large quantities wooden...
A Palauan specimen of the ascidian Lissoclinum patella contained cyclic peptides patellamides A−C. In contrast to previous reports concerning location in L. and bistratum, it has been demonstrated that these were not located symbiotic cyanobacterium Prochloron sp. but instead distributed throughout tunic. The relevance results with respect biosynthetic origins is discussed.
Success in biological control of plant diseases remains inconsistent the field. A collection well-characterized Streptomyces antagonists (n = 19 isolates) was tested for their capacities to inhibit pathogenic scabies 15 isolates). There significant variation among ability pathogen isolates and pathogens susceptibility inhibition. Only one antagonist could all pathogens, antagonist-pathogen interactions were highly specific, highlighting limitations single-strain inoculum control. However, be...
One new isochromane (pseudoanguillosporin C, 2), seven isochromanones (soudanones A–G, 3–9), and six known analogues including 10 11 were isolated from a culture of the fungus Cadophora sp. 10-5-2 M, collected subterranean 10th level Soudan Underground Iron Mine in Minnesota. All compounds tested against panel microbial pathogens, 2, 3, 10, found to have activity Cryptococcus neoformans (MIC = 35, 40, 20, 30 μg/mL, respectively). Compound was also active Candida albicans, with an MIC 40 μg/mL.
Aims: To study the associations between occupational exposures and risk of lung cancer in New Caledonia. Methods: All cases diagnosed January 1993 December 1995 (228 cancers) 305 population controls were included. Detailed information on lifetime job history, smoking, other potential factors was collected by interview. Occupational assessed from questionnaires an industrial hygienist, without knowledge case-control status. Results: No significant association found with related to nickel...
White-nose syndrome (WNS) is a devastating fungal disease that has been causing the mass mortality of hibernating bats in North America since 2006 and caused by psychrophilic dermatophyte Pseudogymnoascus destructans. Infected shed conidia into hibernaculum sediments surfaces, but it unknown if P. destructans can form stable, reproductive populations outside its bat hosts. Previous studies have found non-pathogenic hibernacula, these fungi may provide insight natural history We compared...
Antiapoptotic Bcl-2 family proteins are validated cancer targets composed of six related proteins. From a drug discovery perspective, these challenging that exert their cellular functions through protein-protein interactions (PPIs). Although several isoform-selective inhibitors have been developed using structure-based design or high-throughput screening (HTS) synthetic chemical libraries, no large-scale screen natural product collections has reported. A competitive displacement fluorescence...