A5072282239- SARS-CoV-2 and COVID-19 Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- SARS-CoV-2 detection and testing
- Folate and B Vitamins Research
- Animal Virus Infections Studies
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Viral gastroenteritis research and epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Glycogen Storage Diseases and Myoclonus
- Genetic Syndromes and Imprinting
- COVID-19 Clinical Research Studies
- COVID-19 diagnosis using AI
- Lipoproteins and Cardiovascular Health
- CRISPR and Genetic Engineering
- Genomics and Rare Diseases
- Genetic Associations and Epidemiology
- Vitamin D Research Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Ion channel regulation and function
- Forensic and Genetic Research
- Glioma Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Lipid metabolism and disorders
Université Mohammed VI des Sciences de la Santé
2020-2024
Institut Pasteur du Maroc
2010-2021
University of Health Science
2020
University of Health Sciences
2020
Institut Pasteur
2014
University of Hassan II Casablanca
2010
In late December 2019, an emerging viral infection COVID-19 was identified in Wuhan, China, and became a global pandemic. Characterization of the genetic variants SARS-CoV-2 is crucial following evaluating it spread across countries. this study, we collected analyzed 3,067 genomes isolated from 55 countries during first three months after onset virus. Using comparative genomics analysis, traced profiles whole-genome mutations compared frequency each mutation studied population. The...
The COVID-19 pandemic has been ongoing since its onset in late November 2019 Wuhan, China. Understanding and monitoring the genetic evolution of virus, geographical characteristics, stability are particularly important for controlling spread disease especially development a universal vaccine covering all circulating strains. From this perspective, we analyzed 30,983 complete SARS-CoV-2 genomes from 79 countries located six continents collected 24 December 2019, to 13 May 2020, according...
Abstract In late December 2019, an emerging viral infection COVID-19 was identified in Wuhan, China, and became a global pandemic. Characterization of the genetic variants SARS-CoV-2 is crucial following evaluating it spread across countries. this study, we collected analyzed 3,067 genomes isolated from 55 countries during first three months after onset virus. Using comparative genomics analysis, traced profiles whole-genome mutations compared frequency each mutation studied population. The...
The methylenetetrahydrofolate reductase (MTHFR) gene is one of the main regulatory enzymes involved in folate metabolism, DNA synthesis and remethylation reactions. influence MTHFR variants on male infertility not completely understood. objective this study was to analyze distribution C677T A1298C using PCR-Restriction Fragment Length Polymorphism (RFLP) a case group consisting 344 men with unexplained reduced sperm counts compared 617 ancestry-matched fertile or normozoospermic controls....
The insulin-like growth factor 2 mRNA-binding protein (IGF2BP2) and the cyclin-dependent kinase 5 regulatory subunit-associated 1-like 1 (CDKAL1) identified through genome-wide association (GWA) studies have been shown to be associated with Type diabetes in various ethnic groups. In this study, we investigated of rs7756992 CDKAL1 rs4402960 IGF2BP2 diabetes, diabetic complications (nephropathy, retinopathy cardiovascular disease), obesity hypertension a Tunisian population.A case-control...
Aims: Type 2 diabetes mellitus (T2DM) is a major public health problem around the world. The C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene have been reported to be associated with T2DM its complications. This study aimed investigate this association in Moroccan population. Methods: A case-control was performed among 282 diabetic patients 232 healthy controls. MTHFR were genotyped by polymerase chain reaction, followed enzymatic digestion HinfI MboII...
The goal of the study is to investigate association between APOA5 polymorphisms and haplotypes with Arterial Hypertension (AHT) in Moroccan patients. was performed 283 subjects, 149 patients AHT 134 controls. All subjects were genotyped for -1131 T > C (rs662799), 56C G (rs3135506) c.553G (rs2075291) polymorphisms. There a strong AHT. significantly associated increased systolic blood pressure (SBP) triglycerides (TG) levels. 4 frequency higher than 5%, constructed from polymorphisms,...
Abstract The COVID-19 pandemic has been ongoing since its onset in late November 2019 Wuhan, China. Understanding and monitoring the genetic evolution of virus, geographical characteristics, stability are particularly important for controlling spread disease especially development a universal vaccine covering all circulating strains. From this perspective, we analyzed 30,983 complete SARS-CoV-2 genomes from 79 countries located six continents collected December 24, 2019, to May 13, 2020,...
Here, we report the draft genome sequences of six severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains. SARS-CoV-2 is responsible for COVID-19 pandemic, which started at end 2019 in Wuhan, China. The isolates were obtained from nasopharyngeal swabs Moroccan patients with COVID-19. Mutation analysis revealed presence spike D614G mutation all genomes, widely present several genomes around world.
The Mediterranean basin has been the theater of migration crossroads followed by settlement several societies and cultures in prehistoric historical times, with important consequences on genetic genomic determinisms. Here, we present Founder Mutation Database (MFMD), established to offer web-based access founder mutation information population. data were collected from literature other online resources systematically reviewed assembled into this database. provided for each includes DNA...
In this case–control study we investigated the relative contribution of commons APOA5 polymorphisms and haplotypes to risk metabolic syndrome in Moroccan patients. Using International Diabetes Federation (IDF) criteria for syndrome, included 176 patients 105 controls. We genotyped (−1131 T > C, c.56C G, c.553G c.1259 C) by PCR-RFLP analysis. The effects constructed on were estimated using logistic regression analyses. statistical analysis showed a significant association between -1131 C G...
Abstract Background WAGR syndrome is a rare genetic disorder characterized by de novo deletion of 11p13 and usually clinically associated with Wilms’ tumor, aniridia, genitourinary anomalies, mental retardation (W-A-G-R). Although the genotypic defects in have been well established. The congenital aniridia caused, nearly 90% cases mutations gene PAX6. In face it imperative to specify whether falls within scope or if an isolated inherited performing karyotype, FISH (Fluorescence Situ...
Abstract Background Multiple myeloma (MM) is a disease characterized by heterogeneous clinical presentations as well complex genetic and molecular abnormalities. In MM, cytogenetic analysis challenge because of the low proliferation malignant plasma cells. Thus, interphase fluorescence in situ hybridization (FISH), performed on sorted cells detected abnormalities independently proliferative infiltrative index. The purpose this study was to explore, for first time, genetics features Moroccan...
In this study, we investigated the association of mtDNA variants and haplogroups with Type 2 diabetes (T2D) in Moroccan patients. The Hypervariable Segments 1 was sequenced 108 diabetic patients 97 controls. Association analyses were performed using Fisher's exact test multivariate logistic regression. prevalence five (C16187T, C16270T, T16172C, A16293G, C16320T) significantly higher cases than Among these variants, only C16270T (p = .02) C16320T .03) remains significant after adjusting by...
Abstract The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), is a new infectious that first emerged in Hubei province, China, December 2019. On March 2020, the Moroccan Ministry of Health confirmed COVID-19 case Morocco. virus SARS-CoV-2 was identified sample expatriate residing Italy. Without therapeutic vaccine or specific antiviral drugs, early detection and isolation become essential against novel Coronavirus. This study aims to analyze...
Coronary artery diseases (CAD) are clinical cardiovascular events associated with dyslipidemia in common. The interaction between environmental and genetic factors can be responsible for CAD. present paper aimed to examine the association c.56C > G (rs3135506) APOA5 gene polymorphism CAD Moroccan individuals perform an update meta-analysis. variant was genotyped 122 patients 134 unrelated controls. Genetic analysis comparison of biochemical parameters were performed using R statistical...