A5053857956- SARS-CoV-2 and COVID-19 Research
- Genomics and Phylogenetic Studies
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Mycobacterium research and diagnosis
- Plant Pathogenic Bacteria Studies
- Microbial Community Ecology and Physiology
- Genomics and Rare Diseases
- Bacteriophages and microbial interactions
- Genetic Associations and Epidemiology
- CRISPR and Genetic Engineering
- Plant-Microbe Interactions and Immunity
- vaccines and immunoinformatics approaches
- SARS-CoV-2 detection and testing
- Forensic and Genetic Research
- Vibrio bacteria research studies
- COVID-19 epidemiological studies
- BRCA gene mutations in cancer
- Veterinary medicine and infectious diseases
- Cancer Genomics and Diagnostics
- Mosquito-borne diseases and control
- Estrogen and related hormone effects
- Bacterial biofilms and quorum sensing
- Connexins and lens biology
- Plant tissue culture and regeneration
Mohammed V University
2017-2024
In late December 2019, an emerging viral infection COVID-19 was identified in Wuhan, China, and became a global pandemic. Characterization of the genetic variants SARS-CoV-2 is crucial following evaluating it spread across countries. this study, we collected analyzed 3,067 genomes isolated from 55 countries during first three months after onset virus. Using comparative genomics analysis, traced profiles whole-genome mutations compared frequency each mutation studied population. The...
The COVID-19 pandemic has been ongoing since its onset in late November 2019 Wuhan, China. Understanding and monitoring the genetic evolution of virus, geographical characteristics, stability are particularly important for controlling spread disease especially development a universal vaccine covering all circulating strains. From this perspective, we analyzed 30,983 complete SARS-CoV-2 genomes from 79 countries located six continents collected 24 December 2019, to 13 May 2020, according...
Abstract In late December 2019, an emerging viral infection COVID-19 was identified in Wuhan, China, and became a global pandemic. Characterization of the genetic variants SARS-CoV-2 is crucial following evaluating it spread across countries. this study, we collected analyzed 3,067 genomes isolated from 55 countries during first three months after onset virus. Using comparative genomics analysis, traced profiles whole-genome mutations compared frequency each mutation studied population. The...
Breast cancer is one of the main global priorities in terms public health. It remains most frequent women and leading cause their death. The human microbiome plays various roles maintaining health by ensuring a dynamic balance with host or appearance pathologies including breast cancer. In this study, we performed an analysis bacterial signature differences between tumor adjacent tissues patients Morocco. Using 16S rRNA gene sequencing, observed that tissue contained much higher percentage...
Abstract The COVID-19 pandemic has been ongoing since its onset in late November 2019 Wuhan, China. Understanding and monitoring the genetic evolution of virus, geographical characteristics, stability are particularly important for controlling spread disease especially development a universal vaccine covering all circulating strains. From this perspective, we analyzed 30,983 complete SARS-CoV-2 genomes from 79 countries located six continents collected December 24, 2019, to May 13, 2020,...
Here, we report the draft genome sequences of six severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains. SARS-CoV-2 is responsible for COVID-19 pandemic, which started at end 2019 in Wuhan, China. The isolates were obtained from nasopharyngeal swabs Moroccan patients with COVID-19. Mutation analysis revealed presence spike D614G mutation all genomes, widely present several genomes around world.
Genetic variations in the human genome represent differences DNA sequence within individuals. This highlights important role of whole sequencing which has become keystone for precision medicine and disease prediction. Morocco is an hub studying population migration mixing history. study presents analysis 3 Moroccan genomes; variant revealed 6 379 606 single nucleotide variants (SNVs) 1 050 577 small InDels. Of those identified SNVs, 219 152 were novel, with 1233 occurring coding regions,...
Autosomal dominant hyper-IgE syndrome (AD-HIES) is linked to negative mutations of the STAT3 protein whose molecular basis for dysfunction unclear and presenting with a variety clinical manifestations only supportive treatment. To establish relationship between impact in different domains severity manifestations, 105 were analyzed their on stability, flexibility, function, binding affinity using Silico approaches. Our results showed that 73% studied have an physicochemical properties...
Ending COVID-19 pandemic requires a collaborative understanding of SARS-CoV-2 and mechanisms. Yet, the evolving nature coronaviruses results in continuous emergence new variants virus. Central to this is need for monitoring system able detect potentially harmful virus real-time. In manuscript, we present International Database Variations (IDbSV), result ongoing efforts curating, analyzing, sharing comprehensive interpretation SARS-CoV-2's genetic variations variants. Through user-friendly...
Abstract The SARS-CoV-2 identified as coronavirus species associated with severe acute respiratory syndrome. At the time of writing, genetic diversity Moroccan strains is poorly documented. present study aims to analyze and identify variants fortyeight collected from mid-March end May prediction their possible sources. Our results revealed 108 mutations in SARS-CoV-2, 50% were non-synonymous seven genes (S, M, N, E, ORF1ab, ORF3a, ORF8) variable frequencies. Remarkably, eight predicted have...
Small molecule antagonists that bind to the ligand-binding domain (LBD) of estrogen receptor alpha (ERα) are effective in treating ERα-positive breast cancer patients. However, acquired treatment resistance is observed presence somatic mutations LBD ERα. Y537S most aggressive mutation, causing constitutive activity ERα absence ligand and reducing affinity sensitivity certain such as 4-hydroxy tamoxifen (4-OHT). To better understand mechanism 4-OHT, we performed a comparative study wild-type...
ABSTRACT This report describes the whole-genome shotgun sequences of two multidrug-resistant Acinetobacter baumannii strains, ABE8_07 and ABE12_M, isolated from a Moroccan hospital floor. These genome will initiate study characterization in Morocco.
Here, we report the draft genome sequence of Stenotrophomonas maltophilia MDMC339, a strain able to survive in difficult conditions imposed by Merzouga desert. The analyzed contains 4,788,525 bp with 4,262 genes coding for proteins, including several related stress.
Hereditary deafness is clinically and genetically heterogeneous. We investigated segregating as a recessive trait in two families. Audiological examinations revealed an asymmetric mild to profound hearing loss with childhood or adolescent onset. Exome sequencing of probands identified homozygous c.475G>A;p.(Glu159Lys) variant CLDN9 (NM_020982.4) one family c.370_372dupATC;p.(Ile124dup) affected individual second family. Claudin 9 (CLDN9) integral membrane protein constituent epithelial...
<title>Abstract</title> Africa's 1.5 billion people are underrepresented in genomic databases. The African Genome Variation Project exclusively studied populations south of the Sahara, making Morocco, on northwest coast, a desirable genetic variety study site. Understanding variation and customized therapy require population-specific reference genomes. This presents Phase 1 results from Moroccan (MGP), which sequenced 109 Of 27 million variations we found, 1.4 were unique 15,378 highly...
We report the draft genome sequences of three Pseudomonas chengduensis strains isolated from sand dunes Merzouga (MDMC17 strain) and Erg Lihoudi (MDMC216 MDMC224 strains) regions in Moroccan desert. These bacteria are able to tolerate harsh environmental conditions desert ecosystem.
We report the draft genome sequences of Enterobacter hormaechei subsp. xiangfangensis strains MDMC82 and MDMC76, which were isolated from sand dunes Merzouga desert in Moroccan Sahara. These bacteria are able to tolerate harsh environmental conditions desert.
The increasing commercialization of new gene panels based on next-generation sequencing for clinical research has significantly improved our understanding breast cancer genetics and led to the discovery mutation variants. study included 16 unselected Moroccan patients tested with multi-gene panel (HEVA screen panel) using Illumina Miseq, followed by Sanger validate most relevant mutation. Mutational analysis revealed presence 13 mutations (11 single-nucleotide polymorphisms [SNPs] 2 indels),...
affects up to 50% of people worldwide. Here, we present the draft genome sequences six
Mycobacterium tuberculosis is known to cause pulmonary and extrapulmonary tuberculosis. In Morocco, the spread of multidrug-resistant (MDR) (TB) has become a major challenge. Here, we announce draft genome sequences two strains, MTB1 MTB2, isolated from patients with in describe variants associated drug resistance.