A5052338940- DNA Repair Mechanisms
- Skin and Cellular Biology Research
- Genomics and Rare Diseases
- RNA regulation and disease
- Genetic Associations and Epidemiology
- Lysosomal Storage Disorders Research
- Dermatological and Skeletal Disorders
- BRCA gene mutations in cancer
- Genetic and rare skin diseases.
- Genetics and Neurodevelopmental Disorders
- Carcinogens and Genotoxicity Assessment
- Genomic variations and chromosomal abnormalities
- Wnt/β-catenin signaling in development and cancer
- Metabolism and Genetic Disorders
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Connexins and lens biology
- Hearing, Cochlea, Tinnitus, Genetics
- Porphyrin Metabolism and Disorders
- Nutrition, Genetics, and Disease
- Glycogen Storage Diseases and Myoclonus
- Carbohydrate Chemistry and Synthesis
- Mitochondrial Function and Pathology
- Retinal Diseases and Treatments
Tunis El Manar University
2015-2024
Institut Pasteur de Tunis
2015-2024
Tunis University
2014-2024
Institut National des Sciences et Technologies de la Mer
2020
Institut National de Nutrition et de Technologie Alimentaire
2017
Hôpital Charles-Nicolle
2006-2015
Institut Pasteur
1997-2014
Genomics (United Kingdom)
2013
Centre National de la Recherche Scientifique
1995-2010
University of Louisiana at Lafayette
2010
We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders cancers, which together are the predominant problem of 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care multi-scale, multi-modal multi-level systems approaches tackle NCDs as a common group diseases. Rather than studying each...
Despite rising incidence and mortality rates in Africa, cancer has been given low priority the research field healthcare services. Indeed, 57% of all new cases around world occur income countries exacerbated by lack awareness, preventive strategies, increased life expectancies. recent efforts devoted to epidemiology, statistics on Africa are often dispersed across different registries. In this study our goal included identifying most promising prevention treatment approaches available...
Branchio-oto-renal (BOR) syndrome is an autosomal dominant disorder, characterised by the association of branchial, otic and renal anomalies with variable degrees severity. We have recently identified EYA1, a human homologue Drosophila eyes absent gene, as gene underlying this syndrome. The products both genes share highly conserved 271 amino acid C-terminal region (eyaHR). eyaHR was also found in two other (EYA2 EYA3), demonstrating existence novel family. report here on complete genomic...
Genome-wide Association Studies (GWAS) revealed novel genetic markers for breast cancer susceptibility. But little is known about the risk factors and molecular events associated with in Arab Population. Therefore, we designed a broad study to investigate susceptibility prognostic implications of GWAS loci Tunisian population. In cohort 640 unrelated patients 371 healthy control subjects, characterized variation 9 single nucleotide polymorphisms (SNPs), namely rs1219648, rs2981582;...
Abstract Gut microbiota plays an important role in the regulation of immune system and host’s metabolism. We aimed to characterize gut Tunisian participants with without diabetes. enrolled ten type 1 diabetes mellitus (T1DM), patients 2 (T2DM), 11 subjects Bacteria was quantified fecal samples by quantitative PCR (qPCR). Statistical tests multivariate analysis were performed using RStudio program. Results showed that proportions Firmicutes, Akkermansia muciniphila, Faecalibacterium...
Abstract Background Tunisia is a North African country of 10 million inhabitants. The native background population Berber. However, throughout its history, has been the site invasions and migratory waves allogenic populations ethnic groups such as Phoenicians, Romans, Vandals, Arabs, Ottomans French. Like neighbouring Middle Eastern countries, Tunisian shows relatively high rate consanguinity endogamy that favor expression recessive genetic disorders at rates. Many factors could contribute...
Abstract Adverse drug reactions (ADR) represent a significant contributor to morbidity and mortality, imposing substantial financial burden. Genetic ancestry plays crucial role in response. The aim of this study is characterize the genetic variability selected pharmacogenes involved with ADR Tunisians Italians, comparative analysis against global populations. A cohort 135 healthy 737 Italians were genotyped using SNP array. Variants located 25 Very Important Pharmacogenes implicated...
Science Shops (SSs) represent a Community-Based Participatory Research (CBPR) model that fosters collaboration between community organizations and research institutions. This highlights the growing importance of ethics in such projects. The study aims to identify analyse ethical challenges encountered during implementation Shop projects within InSPIRES consortium. Eight pilot conducted by were selected for qualitative assessment practices CBPR. Semi-structured interviews with SS...
Summary: We have cloned and expressed the gp63 gene of Leishmania major in BCG to develop a recombinant vaccine against zoonotic cutaneous leishmaniasis. Two different expression systems were investigated. The first system consists pAN, Mycobacterium paratuberculosis promoter, which drives ORF2, an open reading frame IS900. This allows production heterologous polypeptides as hybrids with ORF2 product. second relies on antigenic fragments fusion proteins N-terminal region fortuitum...
Five patients from 4 unrelated Tunisian families who presented with disseminated neonatal infection by Mycobacterium bovis bacille Calmette-Guérin strain were investigated. Two had different homozygous interleukin-12 receptor β1 subunit gene splice-site mutations (64+5G→A and 550-2A→G). siblings 1 patient, all of whom the same town, carried mutation (297del8) within interleukin-12p40 gene. This is first description familial cytokine deficiency reported so far. All complete lack expression...
A family history of breast cancer has long been thought to indicate the presence inherited genetic events that predispose this disease. In North Africa, many specific epidemio-genetic characteristics have observed in families when compared Western populations. Despite these specificities, majority genetics studies performed Africa remain restricted investigation BRCA1 and BRCA2 genes. Thus, comprehensive data at a whole exome or genome level from local patients are lacking. sequencing (WES)...
Objective. The aim of the present study was to investigate whether angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with diabetic nephropathy and type 2 diabetes in Tunisian population. Design. A case-control conducted among 141 unrelated patients (90 patients) or without (51 103 non-diabetic controls normal fasting blood glucose. Genotyping performed using a nested polymerase chain reaction amplification order identify correctly heterozygous...