A5023813944- Genetic Associations and Epidemiology
- Pharmacogenetics and Drug Metabolism
- Alzheimer's disease research and treatments
- Genomics and Rare Diseases
- Bioinformatics and Genomic Networks
- Diet and metabolism studies
- Pain Management and Opioid Use
- Pancreatic function and diabetes
- Genetics and Neurodevelopmental Disorders
- Biochemical Analysis and Sensing Techniques
- Nutritional Studies and Diet
- Berberine and alkaloids research
Faculté de médecine de Tunis
2022-2024
Tunis El Manar University
2022-2024
Institut Pasteur de Tunis
2022-2024
Tunis University
2022
Abstract Adverse drug reactions (ADR) represent a significant contributor to morbidity and mortality, imposing substantial financial burden. Genetic ancestry plays crucial role in response. The aim of this study is characterize the genetic variability selected pharmacogenes involved with ADR Tunisians Italians, comparative analysis against global populations. A cohort 135 healthy 737 Italians were genotyped using SNP array. Variants located 25 Very Important Pharmacogenes implicated...
The prevalence of Type 2 diabetes (T2D) is increasing worldwide. Genetics and lifestyle, especially diet, are contributing factors. Analyses macro- micronutrient intake across global populations may help to explain their impact on glucose homeostasis disease development. To this end, 420 Tunisians were enrolled in a prospective cross-sectional study daily food consumption. Various data collected blood samples drawn for biochemical assay. A 24-h recall questionnaire was obtained from...
Alzheimer's disease (AD) and Type 2 diabetes (T2D) are both age-associated diseases. Identification of shared genes could help develop early diagnosis preventive strategies. Although genetic background plays a crucial role in these diseases, we noticed an underrepresentation tendency North African populations omics studies.First, conducted comprehensive review pathways between T2D AD through PubMed. Then, the function identified variants was investigated using annotation tools including...
Type 2 diabetes (T2D) is a multifactorial disease involving genetic and environmental components. Several genome-wide association studies (GWAS) have been conducted to decipher potential aberrations promoting the onset of this metabolic disorder. These GWAS identified over 400 associated variants, mostly in intronic or intergenic regions. Recently, growing number exome genotyping sequencing experiments coding variants with T2D. Such were mainly European populations, few candidate-gene...
Chronic pain is a major socioeconomic burden in the Mediterranean region. However, we noticed an under-representation of these populations pharmacogenetics management studies. In this context, aimed 1) to decipher pharmacogenetic variant landscape among compared worldwide order identify therapeutic biomarkers for personalized and 2) better understand biological process through