A5085493727- T-cell and B-cell Immunology
- Sleep and Wakefulness Research
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Sleep and related disorders
- Pancreatic function and diabetes
- Chromosomal and Genetic Variations
- Genomic variations and chromosomal abnormalities
- Metabolism, Diabetes, and Cancer
- Genetic Neurodegenerative Diseases
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- American Constitutional Law and Politics
- Epigenetics and DNA Methylation
- Muscle Physiology and Disorders
- Neurogenetic and Muscular Disorders Research
- RNA and protein synthesis mechanisms
- Mitochondrial Function and Pathology
- Cancer Genomics and Diagnostics
- Sleep and Work-Related Fatigue
- Genetics and Neurodevelopmental Disorders
- American History and Culture
- Monoclonal and Polyclonal Antibodies Research
- Genomics and Chromatin Dynamics
- Diabetes Management and Research
Jerusalem University College
2024
Eastern Virginia Medical School
2019-2023
Hadassah Medical Center
2008-2023
Hebrew University of Jerusalem
1994-2023
Weizmann Institute of Science
1972-2021
St. Michael's Hospital
2021
University of Toronto
2021
St George Hospital
2021
St. George Hospital
2021
Inspira Medical Center Woodbury
2020
A gene discovered by positional cloning has been identified as the von Hippel-Lindau (VHL) disease tumor suppressor gene. restriction fragment encompassing showed rearrangements in 28 of 221 VHL kindreds. Eighteen these were due to deletions candidate gene, including three large nonoverlapping deletions. Intragenic mutations detected cell lines derived from patients and sporadic renal carcinomas. The is evolutionarily conserved encodes two widely expressed transcripts approximately 6 6.5...
Non-insulin-dependent diabetes mellitus (NIDDM) is a genetically heterogeneous disorder. Maturity-onset of the young, form NIDDM with an early age onset and autosomal dominant inheritance, can result from mutations in glucokinase, key enzyme glucose metabolism beta cells liver. We studied 32 French families maturity-onset young as well 21 late-onset to determine frequency clinical features glucokinase. Fasting plasma concentrations oral glucose-tolerance tests were used metabolic status. DNA...
Prior to constructing a library of yeast artificial chromosomes (YACs) containing very large human DNA fragments, we performed series preliminary experiments aimed at developing suitable protocol. We found an inverse relationship between YAC insert size and transformation efficiency. Evidence occasional rearrangement within inserts was resulting in clonally stable internal deletions or unstable variations. A protocol developed for preparative electrophoretic enrichment high molecular mass...
This collection of essays, based on the Locke Lectures that Nagel delivered at Oxford University in 1990, addresses conflict between claims group and those individual. attempts to clarify nature - one most fundamental problems moral political theory concludes its reconciliation is essential task any legitimate system.
Pancreatic beta-cell function was studied in six subjects with mutations the enzyme glucokinase (GCK) who were found to have elevated fasting and postprandial glucose levels comparison normoglycemic controls. Insulin secretion rates (ISRs) estimated by deconvolution of peripheral C-peptide values using a two-compartment model individual kinetics obtained after bolus intravenous injections biosynthetic human C-peptide. First-phase insulin secretory responses over 24-h period on weight...
Acquiring a new skill requires learning multiple aspects of task simultaneously. For example, piano sonata the musical notes and being able to implement this goal by appropriate sequence finger movements. After practice, continues develop off-line during period consolidation. Here we show that different procedural memory are processed separately consolidation: Only movement is enhanced over day; whereas only night sleep. This double dissociation suggests distinct systems, enhancing memory,...
Non-insulin-dependent diabetes mellitus (NIDDM) is considered a model of premature atherosclerosis with strong genetic component. We have investigated the role angiotensin-converting enzyme (ACE; EC 3.4.15.1) gene in 316 unrelated NIDDM individuals, 132 who had myocardial infarction or significant coronary stenoses and 184 no history heart disease (CHD). A deletion-polymorphism ACE was recently reported to be associated especially people classified as low risk. Here we report that D allele...