A5053245243- Neuropeptides and Animal Physiology
- Essential Oils and Antimicrobial Activity
- Receptor Mechanisms and Signaling
- Phytochemicals and Antioxidant Activities
- Pharmacological Receptor Mechanisms and Effects
- Natural Antidiabetic Agents Studies
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Genomics, phytochemicals, and oxidative stress
- Adipose Tissue and Metabolism
- Lipid Membrane Structure and Behavior
- Eicosanoids and Hypertension Pharmacology
- Hydrogen's biological and therapeutic effects
- Sesquiterpenes and Asteraceae Studies
- Protein Hydrolysis and Bioactive Peptides
- Meat and Animal Product Quality
- Lipid metabolism and biosynthesis
- Aldose Reductase and Taurine
- Alkaloids: synthesis and pharmacology
- Monoclonal and Polyclonal Antibodies Research
- Vitamin C and Antioxidants Research
- Ginkgo biloba and Cashew Applications
- Bioactive natural compounds
- Collagen: Extraction and Characterization
- Phytochemical and Pharmacological Studies
University of Hassan II Casablanca
2011-2024
Inserm
1997-2000
Roche (France)
1998
Laboratoire de Génétique Cellulaire
1998
Centre National de la Recherche Scientifique
1984-1985
Hôpital Nord
1985
Abstract: In the present study we examined interaction of opiates with δ and μ opioid binding sites in bovine adrenal medulla. [ 3 H][D‐Ala 2 , D‐Leu 5 ]‐enkephalin ([ H]DADLE) presence saturating concentrations morphiceptin was used to analyze site interactions, whereas either H]DADLE [D‐Ser Leu ]‐enkephalinThr 6 (DSLET) or Me‐Phe 4 Gly ‐ol]‐enkephalin H]DAGO) for determination sites. Both were found interact stereo selectively opiates. The affected differentially by proteolytic enzymes...
Abstract: In this study we examined the interaction of opiates with K binding sites in bovine adrenal medulla. [ 3 H]Ethylketocyclazocine (EKC), H]etorphine, and H]bremazocine stereoselective bindings were used to assay these interactions. The found be heterogeneous: identified high affinity all subtypes sites. H]EKC, presence saturating concentrations [D‐Ala 2 , D‐Leut]‐enkephalin (DADLE) (5μ M ), was identify 1 sites, on which dynorphin A (1–13) bound affinity. Either H]EKC or H]etorphine...
Abstract Type 1 diabetes is characterized by insulin deficiency due to the destruction of pancreatic β cells, leading hyperglycemia, which in turn induces vascular complications. In current study, we investigated effect intraperitoneal administration clove essential oil (CEO: 20 mg/kg body weight) on certain oxidative stress and glucose metabolism enzymes, as well expression proinflammatory mediators. Administration CEO diabetic rats showed a significant decline blood levels, total...
Response surface methodology (RSM) with a Box-Behnken design (BBD) was used to optimize the extraction of bioactive compounds from Ephedra fragilis. The results suggested that 61.93% ethanol at 44.43 °C for 15.84 h best solution this combination variables. crude extract (CEE) obtained under optimum conditions sequentially fractionated solvents increasing polarity. content total phenolic (TP) and flavonoid (TF) as well antioxidant antiglycation activities were measured. phytochemical...
The purpose of this work was to investigate the protective effect five essential oils (EOs); Rosmarinus officinalis, Thymus vulgaris, Origanum compactum Benth., Eucalyptus globulus Labill. and Ocimum basilicum L.; against oxidative stress induced by hydrogen peroxide in Saccharomyces cerevisiae. chemical composition EOs analyzed gas chromatography (GC) chromatography-mass spectrometry (GC/MS). vitro antioxidant activity evaluated investigated. Yeast cells were pretreated with different...
Lavandula mairei is an aromatic, and medicinal plant endemic to Morocco, mainly found in the southeastern region of Kingdom, used traditional medicine for its many benefits. The purpose study was identify chemical composition essential oil using Gas Chromatography - Tandem Mass Spectrometry, evaluate antimicrobial activity against bacterial strains (Staphylococcus aureus, Staphylococcus aureus MRSA, Enterococcus faecalis, Escherichia coli ATCC 25922, coli, Klebsiella pneumoniae 700603), two...
Abstract This study determined the chemical composition of Cinnamomum verum J.Presl, Cistus ladaniferus L., Laurus nobilis L. , Senecio anteuphorbuim, Boswellia serrata Roxb. ex Colebr. and Schinus molle essential oils (EOs) by gas chromatography‐mass spectrometry. Moreover, six EOs were screened in order to reveal their antibacterial antioxidant activities. They initially tested against pathogenic bacteria: Staphylococcus aureus (MRSA: methicillin‐resistant ), Escherichia coli (ESBL:...
ABSTRACT The aril of the plant Myristica fragrans is one most broadly used spices in Moroccan gastronomy. This research demonstrated its antimicrobial activity against both gram‐positive and gram‐negative bacterial species. Likewise, toxicity was investigated on Swiss albino mice. Mice were treated orally with 0.003 0.3 mg/day during 7 days. Plasmatic markers antioxidant defense systems assessed histological alterations evaluated. Our results showed a significant increase creatine...
Five ethanol extracts of wild plants from the Casablanca region (Morocco) used in local traditional medicine for treatment inflammatory diseases were evaluated their vivo topical anti-inflammatory activity (inhibition carrageenan-induced ear edema mice) and vitro antioxidant antiradical properties linoleic acid oxidation, DPPH radical scavenging). All showed an effect: 300 μg/cm 2 provoked reductions ranging 22 to 28%. also exerted scavenging and/or properties, most active plant being Mentha...
Artemisia campestris L. commonly known as Allal in the southeastern region of Morocco (Tigri-Tendrara) is a medicinal plant. The seeds this species are particularly used by local population preparation traditional medicine. For first time, essential oil obtained from hydrodistilled Moroccan was analyzed GC-FID and GC-MS. A total fifty-four compounds amounting 86.7% were identified. major components β-pinene (12.0%), spathulenol (10.8%), α-pinene (7.5%), limonene (7.0%) o-cymene (5.4%)....
Numerous studies have suggested that the antiproliferative potency of somatostatin (SS) analogues may be an efficient tool to improve prognosis colorectal cancer. In order facilitate current efforts design potent antitumour SS analogues, we studied distribution human receptors (hsst1-5) mRNAs in a large set tumoural and normal colonic tissues. Localisation hsst1-5 tissues was performed by situ hybridisation using radioactive antisense or sense riboprobes. Semi-quantitative analysis hsst5...
Acetaminophen (Paracetamol) is among the most commonly used analgesic and antipyretic drugs worldwide, itâs often, but anomalously, classified as non-steroidal anti-inflammatory (NSAIDs) in textbooks of pharmacology . This study aims to evaluate if paracetamol has an antioxidant effect, relative its weak activities, or it possesses a cytotoxic potential. Oxidative stress was induced by intraperetoneal injection peroxide hydrogen (H<SUB>2</SUB>O<SUB>2</SUB>), then comparative made...