A5101405251- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Animal Disease Management and Epidemiology
- Virus-based gene therapy research
- Microbial Metabolic Engineering and Bioproduction
- SARS-CoV-2 detection and testing
- Invertebrate Immune Response Mechanisms
- Plant Molecular Biology Research
- Vector-Borne Animal Diseases
- Plant-Microbe Interactions and Immunity
- Viral Infectious Diseases and Gene Expression in Insects
- Aquaculture disease management and microbiota
- Genomics and Chromatin Dynamics
- Plant Gene Expression Analysis
- T-cell and Retrovirus Studies
- Plant Pathogenic Bacteria Studies
- Biofuel production and bioconversion
- Enzyme Production and Characterization
- Plant Virus Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Probiotics and Fermented Foods
- Enzyme Catalysis and Immobilization
- Photosynthetic Processes and Mechanisms
- Wheat and Barley Genetics and Pathology
South China Agricultural University
2021-2025
Ji Hua Laboratory
2022-2025
Liaoning Normal University
2012-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Shandong University
2015-2024
Shenzhen Metro (China)
2024
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
Shantou University
2021-2023
Rice Research Institute
2023
Significance Biosynthesis of the plant immune signal salicylic acid (SA) is normally induced upon pathogen challenge through transcriptional activation key SA synthetic enzyme gene, ICS1 . However, how different pathogenic signals trigger synthesis in both local and systemic tissues during responses poorly understood. Our study filled this knowledge gap by identification two transcription factors (TFs): one required for biosynthesis stomata to prevent entry these epidermal openings, other...
Genomic surveillance is a critical tool for tracking emerging variants of SARS-CoV-2 (the virus that causes COVID-19), which can exhibit characteristics potentially affect public health and clinical interventions, including increased transmissibility, illness severity, capacity immune escape. During June 2021-January 2022, CDC expanded genomic data sources to incorporate sequence from repositories produce weighted estimates variant proportions at the jurisdiction level refined analytic...
CDC has used national genomic surveillance since December 2020 to monitor SARS-CoV-2 variants that have emerged throughout the COVID-19 pandemic, including Omicron variant. This report summarizes U.S. trends in variant proportions from during January 2022-May 2023. During this period, remained predominant, with various descendant lineages reaching predominance (>50% prevalence). first half of 2022, BA.1.1 reached by week ending 8, followed BA.2 (March 26), BA.2.12.1 (May 14), and BA.5 (July...
Abstract Heterosis, the phenotypic superiority of a hybrid over its parents, has been demonstrated for many traits in Arabidopsis thaliana , but effect on defence remains largely unexplored. Here, we show that hybrids between some A. accessions increased resistance to biotrophic bacterial pathogen Pseudomonas syringae pv. tomato ( Pst ) DC3000. Comparisons transcriptomes these and their parents after inoculation reveal several key salicylic acid (SA) biosynthesis genes are significantly...
Abstract To detect new and changing SARS-CoV-2 variants, we investigated candidate Delta–Omicron recombinant genomes from Centers for Disease Control Prevention national genomic surveillance. Laboratory bioinformatic investigations identified validated 9 genetically related viruses with a hybrid spike protein.
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence new variant lineages that have exacerbated COVID-19 pandemic. Some those variants were designated as concern/interest (VOC/VOI) by national or international authorities based on many factors including their potential impact vaccine-mediated protection from disease. To ascertain and rank risk VOCs VOIs, we analyze ability 14 (614G, Alpha, Beta, Gamma, Delta, Epsilon, Zeta, Eta, Theta,...
African swine fever (ASF) is a highly infectious disease caused by the virus (ASFV) in swine. It characterized death of cells infected tissues. However, molecular mechanism ASFV-induced cell porcine alveolar macrophages (PAMs) remains largely unknown. In this study, transcriptome sequencing ASFV-infected PAMs found that ASFV activated JAK2-STAT3 pathway early stages and apoptosis late infection. Meanwhile, was confirmed to be essential for replication. AG490 andrographolide (AND) inhibited...
Application of a low-input chromatin profiling method, CUT&RUN, to FACS-purified Arabidopsis endosperm nuclei generates parental-specific genome-wide H3K27me3 landscapes with high sensitivity, specificity and reproducibility. Endosperm is an essential seed tissue unique epigenetic landscape. During development, differential regulation the maternal paternal genomes plays important roles in regulating gene expression, especially at imprinted genes. In Arabidopsis, landscape on scale...
Abstract Recombination between SARS-CoV-2 virus variants can result in different viral properties (e.g., infectiousness or pathogenicity). In this report, we describe viruses with recombinant genomes containing signature mutations from Delta and Omicron variants. These are the first evidence for a Delta-Omicron hybrid Spike protein United States.
Abstract Background The benefits of combining benzoic acid and essential oils (BAO) to mitigate intestinal impairment during the weaning process have been well established, while detailed underlying mechanism has not fully elucidated. Previous research primarily focused on reparative effects BAO injury, neglecting its potential in enhancing stress resistance. Methods In this study, we investigated pre-protective effect against LPS-induced using a modified experimental procedure. Piglets were...
Tanshinones are valuable natural diterpenoids from danshen (Salvia miltiorrhiza Bunge). Here, it was demonstrated that maize transcription factor C1 improved the accumulation of tanshinones by comprehensively upregulating pathway genes, especially SmMDC and SmPMK in hairy roots, yielding total up to 3.59mg g–1 dry weight line C1-6, a 3.4-fold increase compared with control. Investigation 2024bp promoter fragment revealed C1-mediated upregulation terpenoid genes possibly due direct...
The cyanobacterium Synechococcus elongatus PCC 7942 has multiple copies of its single chromosome, and the copy number varies in individual cells, providing an ideal system to study effect genome copy-number variation on cell size gene expression. Using single-cell fluorescence imaging, we found that protein concentration remained constant across cells regardless number. Cell volume total amount from a were both positively, linearly correlated with number, suggesting changes play important...
Abstract African swine fever (ASF) is an acute infectious haemorrhagic of pigs caused by virus (ASFV). Aloe-emodin (Ae) active ingredient Chinese herbs with antiviral, anticancer, and anti-inflammatory effects. We investigated the antiviral activity mechanism action Ae against ASFV using Real-time quantitative PCR (qPCR), western blotting, indirect immunofluorescence assays. significantly inhibited replication. Furthermore, transcriptomic analysis revealed that infection activated NF-κB...
Porcine epidemic diarrhea, characterized by vomiting, dehydration, and is an acute highly contagious enteric disease caused porcine diarrhea virus (PEDV) in neonatal piglets. This has large economic losses to the industry worldwide. Thus, identifying host factors involved PEDV infection important develop novel strategies control transmission. study shows that upregulates karyopherin α 2 (KPNA2) expression Vero intestinal epithelial (IEC) cells. KPNA2 binds degrades E protein via autophagy...
Bacterial extracellular proteases are important for bacterial nutrition and marine sedimentary organic nitrogen degradation. However, only a few from bacteria have been characterized. Some subtilases protease-associated (PA) domain inserted in the catalytic domain. Although structural analysis deletion mutation suggests that PA is involved substrate binding, direct evidence to support this function still absent. Here, protease, P57, secreted by Photobacterium sp. A5-7 isolated sediment was...
African swine fever virus (ASFV) is a complex large DNA enveloped that causes (ASF) with fatality rate of up to 100%, seriously threatening the global industry. Due strict cell tropism ASFV, there no effective in vitro line, which hinders its prevention and control. Herein, we analyzed genome-wide transcriptional profiles ASFV-susceptible porcine alveolar macrophages (PAMs) non-susceptible lines PK15 3D4-21, an found PAM surface pattern recognition receptors (PRRs) were significantly higher...
Porcine epidemic diarrhea (PED) is an enterophilic infectious disease caused by the porcine virus (PEDV), which can lead to dehydration-like in piglets with a mortality rate of up 100%, causing huge economic losses global pig industry. In this study, we isolated two PEDV strains, FS202201 and JY202201, from diarrheal samples collected new PED outbreak farms 2022. We performed phylogenetic analysis S gene whole sequence. The effects different mutations on viral pathogenicity were investigated...