A5065374782- Viral gastroenteritis research and epidemiology
- COVID-19 epidemiological studies
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Influenza Virus Research Studies
- Data-Driven Disease Surveillance
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- Vaccine Coverage and Hesitancy
- Climate Change and Health Impacts
- Hepatitis B Virus Studies
- Infection Control and Ventilation
- Healthcare Policy and Management
- Virus-based gene therapy research
- PI3K/AKT/mTOR signaling in cancer
- Animal Virus Infections Studies
- Salmonella and Campylobacter epidemiology
- Hemoglobinopathies and Related Disorders
- Protein Tyrosine Phosphatases
- Clostridium difficile and Clostridium perfringens research
- Long-Term Effects of COVID-19
National Center for Emerging and Zoonotic Infectious Diseases
2024
Centers for Disease Control and Prevention
2016-2023
Emory University
2016-2022
National Center for Immunization and Respiratory Diseases
2016-2022
Centers for Disease Control and Prevention
2021
Lurie Children's Hospital
2020
CDC Foundation
2020
University of Georgia
2020
Hospital for Sick Children
2009
<h3>Importance</h3> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiology of disease 2019 (COVID-19), is readily transmitted person to person. Optimal control COVID-19 depends on directing resources and health messaging mitigation efforts that are most likely prevent transmission, but relative importance such measures has been disputed. <h3>Objective</h3> To assess proportion SARS-CoV-2 transmissions in community occur from persons without symptoms. <h3>Design, Setting,...
Previous reports of COVID-19 case, hospitalization, and death rates by vaccination status
Genomic surveillance is a critical tool for tracking emerging variants of SARS-CoV-2 (the virus that causes COVID-19), which can exhibit characteristics potentially affect public health and clinical interventions, including increased transmissibility, illness severity, capacity immune escape. During June 2021-January 2022, CDC expanded genomic data sources to incorporate sequence from repositories produce weighted estimates variant proportions at the jurisdiction level refined analytic...
<h3>Importance</h3> The number of SARS-CoV-2 infections and COVID-19–associated hospitalizations deaths prevented among vaccinated persons, independent the effect reduced transmission, is a key measure vaccine impact. <h3>Objective</h3> To estimate adults in US. <h3>Design, Setting, Participants</h3> In this modeling study, multiplier model was used to extrapolate from data on stratified by state, month, age group (18-49, 50-64, ≥65 years) US December 1, 2020, September 30, 2021. These...
SARS-CoV-2, the virus that causes COVID-19, is constantly mutating, leading to new variants (1).Variants have potential affect transmission, disease severity, diagnostics, therapeutics, and natural vaccine-induced immunity.In November 2020, CDC established national surveillance for SARS-CoV-2 using genomic sequencing.As of May 6, 2021, sequences from 177,044 SARS-CoV-2-positive specimens collected during December 20, 2020-May 55 U.S. jurisdictions had been generated by or reported CDC.These...
In the United States, Coronavirus Disease 2019 (COVID-19) deaths are captured through National Notifiable Surveillance System and death certificates reported to Vital Statistics (NVSS). However, not all COVID-19 recognized because of limitations in testing, exacerbation chronic health conditions that listed as cause death, or delays reporting. Estimating may provide a more comprehensive understanding total COVID-19–attributable deaths. We estimated unrecognized attributable deaths, from...
Background In the United States, COVID-19 is a nationally notifiable disease, meaning cases and hospitalizations are reported by states to Centers for Disease Control Prevention (CDC). Identifying reporting every case from facility in States may not be feasible long term. Creating sustainable methods estimating burden of established sentinel surveillance systems becoming more important. Objective We aimed provide method leveraging data create long-term solution estimate monthly rates...
Identifying asymptomatic individuals early through serial testing is recommended to control coronavirus disease 2019 (COVID-19) in nursing homes, both response an outbreak ("outbreak testing" of residents and healthcare personnel) facilities without outbreaks ("nonoutbreak personnel). The effectiveness isolation with or nonoutbreak was evaluated.Using published SARS-CoV-2 transmission parameters, the fraction transmissions prevented (weekly, every 3 days, daily) persons compared...
Abstract Background Although most adults infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) fully recover, a proportion have ongoing symptoms, or post-COVID conditions (PCC), after infection. The objective of this analysis was to estimate the number United States (US) activity-limiting PCC on 1 November 2021. Methods We modeled prevalence using reported infections occurring from February 2020 30 September 2021, and population-based, household survey data new symptoms...
Salmonella enterica bacteria are a leading cause of foodborne illness in the United States; however, most illnesses not associated with known outbreaks, and predicting source sporadic remains challenge. We used supervised random forest model to determine likely sources responsible for human salmonellosis cases States. trained by using whole-genome multilocus sequence typing data from 18,661 isolates collected single food feature selection subset loci influential prediction. The overall...
ABSTRACT The COVID‐19‐Associated Hospitalization Surveillance Network (COVID‐NET) was established in March 2020 to monitor trends hospitalizations associated with SARS‐CoV‐2 infection. COVID‐NET is a geographically diverse population‐based surveillance system for laboratory‐confirmed COVID‐19‐associated combined catchment area covering approximately 10% of the US population. Data collected includes monthly counts persons confirmed infection who reside within defined area. A Bayesian modeling...
Noroviruses are the leading cause of acute gastroenteritis and foodborne diarrheal disease in United States. Norovirus vaccine development has progressed recent years, but critical questions remain regarding which age groups should be vaccinated to maximize population impact.We developed a deterministic, age-structured compartmental model norovirus transmission immunity U.S.The was fit age-specific monthly U.S. hospitalizations between 1996 2007. We simulated mass immunization both pediatric...
When an influenza pandemic emerges, temporary school closures and antiviral treatment may slow virus spread, reduce the overall disease burden, provide time for vaccine development, distribution, administration while keeping a larger portion of general population infection free. The impact such measures will depend on transmissibility severity timing extent their implementation. To robust assessments layered intervention strategies, Centers Disease Control Prevention (CDC) funded network...
Abstract Norovirus is the leading cause of acute gastroenteritis outbreaks in United States. We estimated basic (R0) and effective (Re) reproduction numbers for 7,094 norovirus reported to National Outbreak Reporting System (NORS) during 2009–2017 used regression models assess whether transmission varied by outbreak setting. The median R0 was 2.75 (interquartile range [IQR] 2.38–3.65), Re 1.29 (IQR 1.12–1.74). Long-term care assisted living facilities had an 3.35 (95% CI 3.26–3.45), but did...
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Abstract Background SARS-CoV-2 outbreaks in nursing homes can be large with high case fatality. Identifying asymptomatic individuals early through serial testing is recommended to control COVID-19 homes, both response an outbreak (“outbreak testing” of residents and healthcare personnel) facilities without (“non-outbreak personnel). The effectiveness isolation or non-outbreak was evaluated. Methods Using published transmission parameters, the fraction transmissions prevented (weekly, every...
Norovirus is the leading cause of acute gastroenteritis and foodborne disease in United States. The Food Drug Administration recommends that food workers infected with norovirus be excluded from workplace while symptomatic for 48 hours after their symptoms subside. Compliance this recommendation not ideal, population-level impacts changes food-worker compliance have yet to quantified. We aimed assess population varying degrees current through use a compartmental model. modeled number...
Background Prior to vaccine introduction in 2006, rotavirus was the leading cause of severe diarrhea children under five years age U.S. Vaccination infants has led major reductions disease burden, a shift seasonal peak and emergence biennial pattern disease. However, coverage remained relatively low (70–75%) compared other infant immunizations Part reason for this lower is that whose care provided by family practitioners (FP) have considerably probability being vaccinated those seen be...
Noroviruses are the leading cause of acute gastroenteritis in United States and outbreaks frequently occur daycare settings. Results norovirus vaccine trials have been promising, however there open questions as to whether vaccination children would be cost-effective. We investigated incremental cost-effectiveness a hypothetical for settings compared no vaccination. conducted model-based analysis using disease transmission model attending daycare. Vaccination with 90% coverage rate addition...