Paul A. Gastañaduy

ORCID: 0000-0003-2690-4799
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About
Contact & Profiles
Research Areas
  • Virology and Viral Diseases
  • Vaccine Coverage and Hesitancy
  • Viral gastroenteritis research and epidemiology
  • COVID-19 epidemiological studies
  • Hepatitis Viruses Studies and Epidemiology
  • Viral Infections and Outbreaks Research
  • Immune responses and vaccinations
  • Viral Infections and Immunology Research
  • Zoonotic diseases and public health
  • Respiratory viral infections research
  • Travel-related health issues
  • Infection Control and Ventilation
  • SARS-CoV-2 and COVID-19 Research
  • Immunodeficiency and Autoimmune Disorders
  • Syphilis Diagnosis and Treatment
  • Animal Virus Infections Studies
  • Animal Disease Management and Epidemiology
  • COVID-19 Digital Contact Tracing
  • Rabies epidemiology and control
  • Virus-based gene therapy research
  • Coronary Artery Anomalies
  • COVID-19 Impact on Reproduction
  • Migration, Health and Trauma
  • Cytomegalovirus and herpesvirus research
  • Cardiovascular Issues in Pregnancy

Centers for Disease Control and Prevention
2016-2025

National Center for Immunization and Respiratory Diseases
2013-2024

University of California, Irvine
2024

Holloman Air Force Base
2022

CDC Foundation
2019

Global Viral
2019

Washington Center
2019

Center for Surveillance, Epidemiology, and Laboratory Services
2016

Epidemic Intelligence Service
2011-2016

University of Central Asia
2016

Although recognized as the leading cause of epidemic acute gastroenteritis across all age groups, norovirus has remained poorly characterized with respect to its endemic disease incidence. Use different methods, including attributable proportion extrapolation, population-based surveillance, and indirect modeling, in several recent studies considerably improved incidence estimates for United States. Norovirus causes an average 570-800 deaths, 56,000-71,000 hospitalizations, 400,000 emergency...

10.3201/eid1908.130465 article EN cc-by Emerging infectious diseases 2013-07-10

As of April 26, 2019, CDC had reported 704 cases measles in the United States since beginning representing largest number country a single year 1994, when 963 occurred, and was declared eliminated* 2000 (1,2). Measles is highly contagious, acute viral illness characterized by fever maculopapular rash; complications include pneumonia, encephalitis, death. Among cases, 503 (71%) were unvaccinated persons 689 (98%) occurred U.S. residents. Overall, 66 (9%) patients hospitalized. Thirteen...

10.15585/mmwr.mm6817e1 article EN MMWR Morbidity and Mortality Weekly Report 2019-04-29

During January 1-October 1, 2019, a total of 1,249 measles cases and 22 outbreaks were reported in the United States. This represents most U.S. single year since 1992 (1), second highest number annually was declared eliminated* States 2000 (2). Measles is an acute febrile rash illness with attack rate approximately 90% susceptible household contacts (3). Domestic can occur when travelers contract outside subsequently transmit infection to unvaccinated persons they expose Among 1,163 (93%)...

10.15585/mmwr.mm6840e2 article EN MMWR Morbidity and Mortality Weekly Report 2019-10-04

Measles is a highly contagious, acute viral illness that can lead to complications such as pneumonia, encephalitis, and death. As result of high 2-dose measles vaccination coverage in the United States improved control World Health Organization's Region Americas, declared elimination (defined interruption year-round endemic transmission) 2000. Importations from other countries where remains continue occur, however, which clusters cases States. To update surveillance data on current...

10.1001/jama.299.22.2621 article EN JAMA 2008-06-10

Although measles was eliminated in the United States 2000, importations of virus continue to cause outbreaks. We describe epidemiologic features an outbreak that originated from two unvaccinated Amish men whom incubating at time their return Philippines and explore effect public health responses on limiting spread measles.

10.1056/nejmoa1602295 article EN New England Journal of Medicine 2016-10-05

Abstract Background Multisystem inflammatory syndrome in children (MIS-C) is a severe hyperinflammatory condition persons aged <21 years associated with antecedent acute respiratory coronavirus 2 (SARS-CoV-2) infection. Our objective was to describe MIS-C cases reported Centers for Disease Control and Prevention’s (CDC’s) national surveillance since the disease 2019 (COVID-19) pandemic began. Methods We included patients meeting case definition onset date from 19 February 2020 through...

10.1093/cid/ciab1007 article EN public-domain Clinical Infectious Diseases 2021-12-02

Gastroenteritis remains an important cause of morbidity in the United States. The burden norovirus gastroenteritis ambulatory US patients is not well understood.Cause-specified and cause-unspecified emergency department (ED) outpatient visits during July 2001-June 2009 were extracted from MarketScan insurance claim databases. By using cause-specified encounters, time-series regression models fitted to predict number unspecified due specific pathogens other than norovirus. Model residuals...

10.1093/infdis/jis942 article EN The Journal of Infectious Diseases 2013-01-08

Background. Botswana introduced monovalent G1P[8] rotavirus vaccine (RV1) in July 2012, providing one of the first opportunities to assess effectiveness routine RV1 vaccination a high-burden setting Africa. We sought determine against diarrhea hospitalization using case-control evaluation. Methods. Vaccine age-eligible children <5 years age admitted with at 4 hospitals were enrolled from June 2013 April 2015. Card-confirmed history was compared between case patients (children...

10.1093/cid/civ1207 article EN Clinical Infectious Diseases 2016-04-08

The global measles vaccination program has been extraordinarily successful in reducing measles-related disease and deaths worldwide. Eradication of is feasible because several key attributes, including humans as the only reservoir for virus, broad access to diagnostic tools that can rapidly detect measles-infectious persons, availability highly safe effective measles-containing vaccines (MCVs). All 6 World Health Organization (WHO) regions have established elimination goals. Globally, during...

10.1093/infdis/jiaa793 article EN cc-by The Journal of Infectious Diseases 2020-12-29

In Mexico, declines in childhood diarrhea deaths have been documented during 2008-2010 after rotavirus vaccine introduction 2007. Because of concerns about variation efficacy by socioeconomic status, we compared reductions mortality the lesser developed southern region versus more northern and central regions Mexico.We obtained data from national vital statistics on among children aged <5 years 2002 through 2011. We region-specific before (2003-2006) (2009-2011) introduction. Regional...

10.1542/peds.2012-2797 article EN PEDIATRICS 2013-03-05

Background. A monovalent human rotavirus vaccine (RV1) was introduced in Botswana July 2012. We assessed the impact of RV1 vaccination on childhood gastroenteritis-related hospitalizations and deaths 2013 2014. Methods. obtained data from registers 4 hospitals gastroenteritis, regardless cause, among children <5 years age. Gastroenteritis during prevaccine period (January 2009–December 2012) were compared to postvaccine 2013–December 2014). Vaccine coverage estimated collected through a...

10.1093/cid/civ1210 article EN Clinical Infectious Diseases 2016-04-08

In anticipation of introduction a rotavirus vaccine into the national immunization program Bangladesh, active hospital-based surveillance was initiated to provide prevaccine baseline data on disease.Children 5 years age and younger admitted with acute gastroenteritis (AGE) (≥3 watery or looser-than-normal stools ≥1 episode forceful vomiting) at 7 hospitals throughout Bangladesh were identified. Clinical information stool specimens collected from every 4th patient. Specimens tested for...

10.1097/inf.0000000000001381 article EN The Pediatric Infectious Disease Journal 2016-10-29

Measles, a vaccine-preventable disease that can cause severe complications, was declared eliminated from the United States in 2000. The last published summary of US measles epidemiology during 2001–2008. We summarized 2009–2014. compared demographic, vaccination, and virologic data on confirmed cases reported to Centers for Disease Control Prevention January 1, 2009–December 31, 2014 2001–December 2008. During 2009–2014, 1264 were States, including 275 importations 58 countries 66 outbreaks....

10.1093/jpids/piv080 article EN Journal of the Pediatric Infectious Diseases Society 2015-12-13

Although measles was declared eliminated from the United States in 2000, cases and outbreaks continue to occur, resulting importations of disease countries where it remains endemic. We describe epidemiology international virus into during postelimination era. From 2001 2016, 553 imported were reported Centers for Disease Control Prevention. A median 28 occurred each year (range: 18–80). The age case-patients 18 years 3 months–75 years); 87% unvaccinated or had an unknown vaccination status....

10.1093/infdis/jiy701 article EN The Journal of Infectious Diseases 2018-12-04

<h3>Importance</h3> Measles cases and outbreaks continue to occur in the United States after introduction of measles from endemic settings. <h3>Objective</h3> To discern factors associated with transmission had been eliminated. <h3>Design, Setting, Participants</h3> This cross-sectional study was conducted January 1, 2001, December 31, 2017, among US residents international visitors confirmed measles. A maximum likelihood algorithm that uses observed dates rash onset known distribution...

10.1001/jamapediatrics.2019.4357 article EN cc-by JAMA Pediatrics 2019-11-18

Mumps is an acute viral illness that classically presents with parotitis. Although the United States experienced a 99% reduction in mumps cases following implementation of 2-dose vaccination program 1989, has resurged past 10 years.We assessed epidemiological characteristics outbreaks ≥20 reported electronically through National Notifiable Diseases Surveillance System and from supplemental outbreak data direct communications jurisdictions July 2010 December 2015. were defined using 2012...

10.1093/cid/ciy779 article EN public-domain Clinical Infectious Diseases 2018-09-07
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