A5031236850- Animal Vocal Communication and Behavior
- Animal Behavior and Reproduction
- Marine animal studies overview
- Neurobiology and Insect Physiology Research
- Biochemical Analysis and Sensing Techniques
- Pelvic floor disorders treatments
- Music and Audio Processing
- RNA and protein synthesis mechanisms
- Autism Spectrum Disorder Research
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- Multisensory perception and integration
- Platelet Disorders and Treatments
- Photoreceptor and optogenetics research
- Toxin Mechanisms and Immunotoxins
- Cardiac, Anesthesia and Surgical Outcomes
- Virology and Viral Diseases
- Hormonal and reproductive studies
- Parkinson's Disease Mechanisms and Treatments
- Developmental Biology and Gene Regulation
- Crustacean biology and ecology
- Echinoderm biology and ecology
- Language and cultural evolution
- Streptococcal Infections and Treatments
- Advanced Radiotherapy Techniques
University of Arizona
2006-2025
Language Computer (United States)
2018
Knox County Health Department
2016
University of Florida
2015
Laboratoire d’immunologie intégrative du cancer
2014
University of California, Los Angeles
2007-2012
University of Utah
2008
Northwestern University
2005-2006
Defence Science and Technology Laboratory
2003
National Institute of Dental and Craniofacial Research
2000
Similarities between speech and birdsong make songbirds advantageous for investigating the neurogenetics of learned vocal communication—a complex phenotype probably supported by ensembles interacting genes in cortico-basal ganglia pathways both species. To date, only FoxP2 has been identified as critical to birdsong. We performed weighted gene coexpression network analysis on microarray data from singing zebra finches discover regulated during behavior. found ∼2,000 singing-regulated...
Although measles was eliminated in the United States 2000, importations of virus continue to cause outbreaks. We describe epidemiologic features an outbreak that originated from two unvaccinated Amish men whom incubating at time their return Philippines and explore effect public health responses on limiting spread measles.
Neuronal plasticity and synaptic remodeling play important roles during the development of invertebrate nervous system. In addition, structural neuroplasticity as a result long-term environmental changes, behavioral modifications, age, experience have been demonstrated in brains sexually mature insects. adult vertebrates, persistent neurogenesis is found granule cell layer mammalian hippocampus subventricular zone, well telencephalon songbirds, indicating that neurogenesis, which presumably...
Cognitive and motor deficits associated with language speech are seen in humans harboring FOXP2 mutations. The neural bases for mutation-related thought to reside structural abnormalities distributed across systems important learning including the cerebral cortex, basal ganglia, cerebellum. In these brain regions, our prior research showed that FoxP2 mRNA expression patterns strikingly similar between developing songbirds. Within songbird brain, this pattern persists throughout life includes...
Abstract Wireless battery free and fully implantable tools for the interrogation of central peripheral nervous system have quantitatively expanded capabilities to study mechanistic circuit level behavior in freely moving rodents. The light weight small footprint such devices enables full subdermal implantation that results capability perform studies with minimal impact on subject yields broad application a range experimental paradigms. While these advantages been successfully proven rodents...
ABSTRACT The mode of embryonic and larval development the ethology metamorphosis in spider crab American lobster are very different, we took advantage this to compare neuronal two species. goals study were discover whether differences maturation neuromuscular system pereopods metamorphic changes motor behavior between species reflected at level developing nervous (‘neurometamorphosis’). Furthermore, wanted broaden our understanding mechanisms that govern arthropods. Proliferation stem cells...
The neuromodulatory interactions of sex steroids with the opioid system may result in differences pain and analgesia. Dynorphin is an endogenous kappa-opioid peptide that upregulated animal model peripheral inflammation hyperalgesia possibly regulated by circulating levels steroids. present study compared behavioral responses male, cycling female, gonadectomized Sprague–Dawley rats a persistent pain. Cycling female were behaviorally tested over 14-day period, their estrous cycles monitored...
Communication and swallowing deficits are common in Parkinson's disease (PD). Evidence indicates that voice speech dysfunction manifest early, prior to motor typically associated with striatal dopamine loss. Unlike the extremities, cranial sensorimotor refractory standard dopamine-related pharmacological surgical interventions, thus mechanisms underlying vocal unclear. Although neurotoxin models have provided some insight, they model nigrostriatal depletion therefore limited. Widespread...
Trial by trial variability during motor learning is a feature encoded the basal ganglia of both humans and songbirds, important for reinforcement optimal patterns, including those that produce speech birdsong. Given many parallels between these behaviors, songbirds provide useful model to investigate neural mechanisms underlying vocal learning. In juvenile adult male zebra finches, endogenous levels FoxP2, molecule critical language, decrease two hours after morning song onset within area X,...
Both avian and mammalian basal ganglia are involved in voluntary motor control. In birds, such movements include hopping, perching flying. Two organizational features that distinguish the songbird striatal pallidal neurons intermingled, dedicated to vocal-motor function clustered together a dense cell group known as area X sits within surrounding striato-pallidum. This specification allowed us perform molecular profiling of two striato-pallidal subregions, comparing transcriptional patterns...
Deterioration in the quality of a person’s voice and speech is an early marker Parkinson’s disease (PD). In humans, neural circuit that supports vocal motor control consists cortico-basal ganglia-thalamo-cortico loop. The basal ganglia regions, striatum globus pallidus, this loop play role modulating acoustic features behavior such as loudness, pitch, articulatory rate. PD, area implicated pathogenesis. animal models accumulation toxic aggregates containing neuronal protein alpha-synuclein...
Midbrain dopamine (DA) modulates the activity of basal ganglia circuitry important for motor control in a variety species. In songbirds, DA underlies motivational behavior including reproductive drive and is implicated as gatekeeper neural governing vocal variability. zebra finch, Taeniopygia guttata, levels increase Area X, song-dedicated subregion ganglia, when male bird sings his courtship song to female (female-directed; FD). Levels remain stable he less stereotyped version that not...
Purpose The zebra finch is used as a model to study the neural circuitry of auditory-guided human vocal production. terminology birdsong production and acoustic analysis, however, differs from voice production, making it difficult for researchers either species navigate literature other. purpose this research note identify common measures better compare information across species. Method Terminology in will be mapped onto literature. Measures typically quantify percepts pitch, loudness,...
Voice changes due to natural aging and neurodegenerative diseases are prevalent in the population diminish quality of life.Most treatments involve behavioral interventions that target larynx because a limited understanding central brain mechanisms.The songbird offers unique entry-point into studying age-related vocalizations well-characterized neural circuitry for song shares homology human vocal control areas.Previously, we established translational dictionary evaluating acoustic features...