A5066162603- Language Development and Disorders
- Reading and Literacy Development
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Neurobiology of Language and Bilingualism
- Phonetics and Phonology Research
- Infant Development and Preterm Care
- Congenital heart defects research
- Genomic variations and chromosomal abnormalities
- Family and Disability Support Research
- RNA and protein synthesis mechanisms
- Cognitive and developmental aspects of mathematical skills
- Infant Health and Development
- High Altitude and Hypoxia
- Children's Physical and Motor Development
- Genomics and Rare Diseases
- Biochemical Analysis and Sensing Techniques
- Voice and Speech Disorders
- Writing and Handwriting Education
- Oil and Gas Production Techniques
- Neuroscience and Music Perception
- Hearing, Cochlea, Tinnitus, Genetics
- CRISPR and Genetic Engineering
- Cardiovascular and exercise physiology
- Animal Vocal Communication and Behavior
Arizona State University
2016-2025
Petronas (Malaysia)
2024
Google (United States)
2010-2023
Saint Louis University
2016-2021
Otto-von-Guericke University Magdeburg
2002-2020
University of Washington
2005-2016
Seattle University
2010-2013
Pfizer (United Kingdom)
2002
University of Glasgow
1988-1995
Eosinophils are recruited to sites of inflammation via the action a number chemical mediators, including PAF, leukotrienes, eotaxins, ECF-A and histamine. Although many cell-surface receptors for these mediators have been identified, histamine-driven chemotaxis has not conclusively attributed any three known histamine receptor subtypes, suggesting possibility 4th histamine-responsive on eosinophils. We identified cloned novel G protein-coupled (GPCR), termed Pfi-013, from an IL-5 stimulated...
Two functionally related genes, FOXP2 and CNTNAP2, influence language abilities in families with rare syndromic common nonsyndromic forms of impaired language, respectively. We investigated whether these genes are associated component phenotypes dyslexia measures sequential motor ability. Quantitative transmission disequilibrium testing (QTDT) linear association modeling were used to evaluate associations phonological memory (nonword repetition, NWR), expressive (sentence repetition),...
<b><i>Background:</i></b> Physical exercise has a positive effect on cognitive performance and quality of life (QoL). One reason for this is the upregulation brain-derived neurotrophic factor, which improves brain plasticity. Intermittent hypoxia promotes first proliferation endogenous neuroprogenitors leads to an increased number newborn neurons second expression factor in adult hippocampus. may, therefore, support synaptic plasticity, process learning provoke...
This article provides an overview of (a) issues in definition and diagnosis specific reading disabilities at the behavioral level that may occur different constellations developmental phenotypic profiles (patterns); (b) rapidly expanding research on genetic heterogeneity gene candidates for dyslexia other disabilities; (c) emerging gene-brain relationships; (d) current understanding epigenetic mechanisms whereby environmental events alter expression variations. A glossary terms (denoted by...
Childhood apraxia of speech (CAS) is a severe and socially debilitating form sound disorder with suspected genetic involvement, but the etiology not yet well understood. Very few known or putative causal genes have been identified to date, e.g., FOXP2 BCL11A. Building knowledge base CAS will make it possible identify infants at risk motivate development effective very early intervention programs. We investigated in two large multigenerational families familial CAS. Complementary genomic...
Purpose: Down syndrome (DS) is associated with lifelong difficulties verbal communication, beginning in infancy when vocalizations are sparse and first words emerge late. Because DS diagnosed at or even before birth, these can be anticipated, yet there have been limited developments of systematic, proactive interventions. The purpose the pilot study described here was to investigate feasibility potential benefits such an intervention toward a fully powered clinical trial. Method: We piloted...
The purpose of this study was to investigate the hypothesis that individuals with dyslexia and childhood apraxia speech share an underlying persisting deficit in processing sequential information. Levels impairment (sensory encoding, memory, retrieval, motor planning/programming) were also investigated. Participants 22 adults dyslexia, 10 a probable history (phCAS), typical controls. All participants completed nonword repetition, multisyllabic real word decoding tasks. Using phonological...
Precision medicine is an emerging approach to managing disease by taking into consideration individual's genetic and environmental profile toward two avenues improved outcomes: prevention personalized treatments. This framework largely geared conditions conventionally falling the field of medical genetics. Here, we show that same improving outcomes can be applied in behavior genomics, specifically disorders spoken language. Babble Boot Camp (BBC) first comprehensive program designed...
The purpose of this study was to evaluate a global deficit in sequential processing as candidate endophenotypein family with familial childhood apraxia speech (CAS). Of 10 adults and 13 children three-generational sound disorder (SSD) consistent CAS, 3 6 had past or present SSD diagnoses. Two preschoolers unremediated CAS showed high number sequencing errors during single-word production. Performance on tasks loads differentiated between the affected unaffected members, whereas there were no...
The aim of this pilot study was to investigate a measure motor sequencing deficit as potential endophenotype speech sound disorder (SSD) in multigenerational family with evidence familial SSD.In motor-based SSD, affectation status and during oral testing were obtained. To further the role an for genetic studies, parametric nonparametric linkage analyses carried out using genome-wide panel 404 microsatellites.In seven 10 members available data, SSD coincided. Linkage analysis revealed four...
Childhood apraxia of speech (CAS) is a proposed disorder subtype that interferes with motor planning and/or programming, affecting prosody in many cases. Pilot data (Peter & Stoel‐Gammon, ) were consistent the notion deficits timing accuracy and music‐related tasks may be associated CAS. This study replicated expanded earlier findings. Eleven children disorders age‐and gender‐matched controls participated non‐word imitation, clapped rhythm paced repetitive tapping tasks. Results suggest...
Interstitial and terminal 6q25 deletions are associated with developmental delays, hypotonia, eye pathologies, craniofacial dysmorphologies, structural brain anomalies. In most cases, speech language deficits not described in detail. We report on a case (Patient 1, age 7 years) de novo 6q25.3‐qter deletion, 11.1 Mb long encompassing 108 genes, 2, 5 an inherited interstitial 6q25.3 located within Patient 1's deletion region 403 kb long, the smallest reported to date. Both children have motor...
Interest in diseases of the nervous system resulting from occupational exposure to mixed organic solvents has greatly increased. The aim our study was identify preclinical effects low-level chronic solvent on central car painters by assessing their cognitive performance.This psychological involved 169 clinically healthy male volunteers (84 and 85 controls) is part a comprehensive investigating exposure. test battery included paper-pencil tests (vocabulary test, block design c.i., d2 test),...
Impaired speech prosody has been identified as a critical feature of suspected childhood apraxia (sCAS). Lexical stress productions children with sCAS have characterized 'excessive/equal/misplaced'. This investigation examines two potential explanations this particular deficit, articulatory difficulty and impaired intrinsic timing. Two diagnosis (ages 4 years, 3 months 9 5 months) age-matched controls were observed during three music tasks. Acoustic analysis revealed that in all tasks, the...
The purpose of this study was to address the hypothesis that childhood apraxia speech (CAS) is influenced by an underlying deficit in sequential processing also expressed other modalities. In a sample 21 adults from five multigenerational families, 11 with histories various familial sound disorders, 3 biologically related family CAS showed motor sequencing deficits alternating task. Compared adults, these three participants tasks requiring high loads processing, including nonword imitation,...
Background: Resistance training (RT) under hypoxic conditions has been used to increase muscular performance normoxic in young people. However, the effects of RT and thus hypoxia (RTH) could also be valuable for parameters physical capacity body composition across lifespan. Therefore, we compared low- moderate-load RTH with matched designed on strength capacity, cardiopulmonary hematological adaptation, vs. older Methods: In a pre-post randomized, blinded, controlled experiment, 42 (18 30...
<ns4:p><ns4:bold>Background:</ns4:bold> Speech and language therapy is typically initiated reactively after a child shows delays. Infants with classic galactosemia (CG), metabolic disease known high risk for both speech disorders, hold the keys towards evaluating whether preventive treatment effective when risks are at birth. We present pilot data from randomized parallel trial of an innovative proactive intervention program, Babble Boot Camp (BBC). </ns4:p><ns4:p>...