A5087241001- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Animal Vocal Communication and Behavior
- T-cell and B-cell Immunology
- Infant Health and Development
- Hepatitis B Virus Studies
- Aquatic Ecosystems and Phytoplankton Dynamics
- Algal biology and biofuel production
- Polyomavirus and related diseases
- Epigenetics and DNA Methylation
- vaccines and immunoinformatics approaches
- Neuroendocrine regulation and behavior
- Viral Infections and Immunology Research
- Clostridium difficile and Clostridium perfringens research
- Biocrusts and Microbial Ecology
- Employment and Welfare Studies
- Animal Behavior and Reproduction
- SARS-CoV-2 detection and testing
- RNA Interference and Gene Delivery
- Plant Molecular Biology Research
- Immune Cell Function and Interaction
- Marine animal studies overview
- Long-Term Effects of COVID-19
Mercy Research
2021-2024
Mercy Hospital
2022
Baylor University
2022
University of California, Los Angeles
2012-2021
Children's Mercy Hospital
2021
Laboratoire d’immunologie intégrative du cancer
2013
Virginia Commonwealth University
2010
Antibody Responses after a Single Dose of SARS-CoV-2 mRNA VaccineTo the Editor: Currently, two vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that involve messenger RNA (mRNA) platform technology have been approved for emergency use by Food and Drug Administration (FDA) (mRNA-1273, Moderna; BNT162b2, Pfizer). 1,2Phase 3 trials these showed greater than 90% efficacy at preventing symptomatic infection doses administered to 4 weeks apart.These primarily involved...
Similarities between speech and birdsong make songbirds advantageous for investigating the neurogenetics of learned vocal communication—a complex phenotype probably supported by ensembles interacting genes in cortico-basal ganglia pathways both species. To date, only FoxP2 has been identified as critical to birdsong. We performed weighted gene coexpression network analysis on microarray data from singing zebra finches discover regulated during behavior. found ∼2,000 singing-regulated...
Abstract Background The global pandemic of coronavirus disease 2019 (COVID-19) is caused by infection with the SARS-CoV-2 virus. Currently, there are three approved vaccines against in USA, including two based on messenger RNA (mRNA) technology that has demonstrated high vaccine efficacy. We sought to characterize humoral immune responses, at resolution, during immunization BNT162b2 (Pfizer-BioNTech) individuals or without prior history natural infection. Methods determined antibody...
SARS-CoV-2 is a novel betacoronavirus that caused coronavirus disease 2019 and has resulted in millions of deaths worldwide. Novel infections humans have steadily become more common. Understanding antibody responses to SARS-CoV-2, identifying conserved, cross-reactive epitopes among strains could inform the design vaccines therapeutics with broad application. Here, we determined individuals previous infection or vaccinated Pfizer-BioNTech BNT162b2 vaccine produced cross-reacted related...
Gunnera plants have the unique ability to form endosymbioses with N2-fixing cyanobacteria, primarily Nostoc. Cyanobacteria enter through transiently active mucilage-secreting glands on stems. We took advantage of nitrogen (N)-limitation-induced gland development in manicata identify factors that may enable plant tissue attract and maintain cyanobacteria colonies. Cortical cells stems N-stressed were found accumulate a copious amount starch, while starch neighboring mature was nearly...
Determining the duration of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines is critical for informing timing booster immunization. Many genetic and environmental factors could influence both magnitude persistence antibody response. Here, we showed that SARS-CoV-2 infection before vaccination age affected decay responses messenger RNA vaccine.
Postnatal immune activation leads to social deficits in a mouse model of TSC by abnormal interferon production microglia.
Abstract Genetic and epigenetic changes in components of the Reelin-signaling pathway ( RELN, DAB1 ) are associated with autism spectrum disorder (ASD) risk. Social communication deficits a key component ASD diagnostic criteria, but underlying neurogenetic mechanisms remain unknown. Reln insufficient mice exhibit ASD-like behavioral phenotypes including altered neonatal vocalization patterns. Reelin affects multiple pathways through receptors, Very low-density lipoprotein receptor (Vldlr),...
Understanding the B cell response to SARS-CoV-2 vaccines is a high priority. High-throughput sequencing of receptor (BCR) repertoire allows for dynamic characterization response. Here, we sequenced BCR individuals vaccinated by Pfizer mRNA vaccine. We compared repertoires with previous COVID-19 infection (seropositive) without (seronegative). discovered that vaccine-induced expanded IgG clonotypes had shorter heavy-chain complementarity determining region 3 (HCDR3), and seropositive...
The SARS-CoV-2 Omicron variant has caused infections among individuals vaccinated or with prior COVID-19, suggesting immune escape. Here, we showed a decrease in binding and surrogate neutralizing antibody responses to the after 2 doses of Pfizer COVID-19 mRNA vaccine. Individuals recovered from infection before vaccination had higher levels avidity compared without infection. This suggested that elicited magnitude affinity response variant, repeated exposure through vaccine may be required...
Abstract Natural killer (NK) cells are cytotoxic innate lymphocytes that provide defense against pathogens and malignancy. New evidence identified NK capable of memory-like immune responses in certain settings. This memory is thought to be imprinted through epigenetic modifications. However, precise epigenic pathways or strategies modulate long-term cell activity not well defined. In this study, we performed a screen an library containing 160 drug compounds with well-characterized regulatory...
Abstract SARS-CoV-2 is a novel betacoronavirus that causes coronavirus disease 2019 and has resulted in millions of deaths worldwide. Novel infections humans have steadily become more common. Understanding antibody responses to SARS-CoV-2, identifying conserved, cross-reactive epitopes among strains could inform the design vaccines therapeutics with broad application. Here, we determined individuals previous infection or vaccinated Pfizer-BioNTech BNT162b2 vaccine produced cross-reacted...
To slow the Great Resignation and mitigate its impact on our economy, leaders must understand similarities differences in characteristics of these generations’ characteristics, work attitudes, trends. While some use generational to drive wedges with younger colleagues, there is tremendous potential embrace leverage strengths make entire team better. There are also many among generations that can be focused upon give everyone common ground understanding, which enhances collaborative creative...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel betacoronavirus causing Coronavirus disease 2019 (COVID-19). B cell receptors (BCRs) are expressed at the surface of and secreted as soluble antibodies. These antibodies can block viral infection by neutralizing virus, critical for resolution SARS-CoV-2 infection, may be correlates protection COVID-19 vaccines. We have previously shown that immunization elicits robust antibody response significantly higher in...