A5061267714- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- HIV Research and Treatment
- Polyomavirus and related diseases
- Immune responses and vaccinations
- Chemokine receptors and signaling
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
University of California, Los Angeles
2016-2021
Modeling studies suggest that clustered structural plasticity of dendritic spines is an efficient mechanism information storage in cortical circuits. However, why new occur specific locations and how their formation relates to learning memory (L&M) remain unclear. Using vivo two-photon microscopy, we track spine dynamics retrosplenial cortex before, during, after two forms episodic-like find turnover before predicts future L&M performance, as well the localization rates clustering....
Although the role of CCR5 in immunity and HIV infection has been studied widely, its neuronal plasticity, learning memory is not understood. Here, we report that decreasing function increases MAPK/CREB signaling, long-term potentiation (LTP), hippocampus-dependent mice, while overexpression caused deficits. Decreasing mouse barrel cortex also resulted enhanced spike timing dependent plasticity consequently, dramatically accelerated experience-dependent plasticity. These results suggest a...
Postnatal immune activation leads to social deficits in a mouse model of TSC by abnormal interferon production microglia.