A5105830444- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Vibrio bacteria research studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Neurofibromatosis and Schwannoma Cases
- Receptor Mechanisms and Signaling
- Bacterial biofilms and quorum sensing
- Aquaculture disease management and microbiota
- Neural dynamics and brain function
- Meningioma and schwannoma management
- Mitochondrial Function and Pathology
- Zebrafish Biomedical Research Applications
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Protein Tyrosine Phosphatases
- Retinal Development and Disorders
- Antibiotic Resistance in Bacteria
- Ion channel regulation and function
- Sports Performance and Training
- Axon Guidance and Neuronal Signaling
- Neuroendocrine regulation and behavior
- Neuroblastoma Research and Treatments
- Autism Spectrum Disorder Research
- Photoreceptor and optogenetics research
University of California, Los Angeles
2014-2024
Behavioral Pharma (United States)
2024
Santa Fe Institute
2024
Public Health Department
2024
Hospital de Clínicas Universidade Federal do Paraná
2023
Universidade Federal do Paraná
2023
Morehouse School of Medicine
2009-2019
University of Trás-os-Montes and Alto Douro
2013-2019
UCLA Health
2019
Neurobehavioral Systems
2010-2018
As a first step in program to use genetically altered mice the study of memory mechanisms, mutant were produced that do not express α-calcium-calmodulin-dependent kinase II (α-CaMKII). The α-CaMKII is highly enriched postsynaptic densities hippocampus and neocortex may be involved regulation long-term potentiation (LTP). Such exhibited mostly normal behaviors presented no obvious neuroanatomical defects. Whole cell recordings reveal including N -methyl-D-aspartate (NMDA) receptor function,...
Although long-term potentiation (LTP) has been studied as the mechanism for hippocampus-dependent learning and memory, evidence this hypothesis is still incomplete. The mice with a mutation in α-calcium-calmodulin-dependent kinase II (α-CaMKII), synaptic protein enriched hippocampus, are appropriate addressing issue because hippocampus of these deficient LTP but maintains intact postsynaptic mechanisms. These mutant exhibit specific impairments, an indication that α-CaMKII prominent role...
Memory retrieval is not a passive phenomenon. Instead, it triggers number of processes that either reinforce or alter stored information. Retrieval thought to activate second memory consolidation cascade (reconsolidation) requires protein synthesis. Here, we show the temporal dynamics reconsolidation are dependent on strength and age memory, such younger weaker memories more easily reconsolidated than older stronger memories. We also report extinction, two opposing triggered by retrieval,...
The calcium-calmodulin–dependent kinase II (CaMKII) is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)–dependent activity, CaMKII can undergo autophosphorylation, resulting in CaM-independent activity. A point mutation was introduced into the αCaMKII gene that blocked autophosphorylation of threonine at position 286 (Thr ) this without affecting CaM-dependent mutant mice had no N -methyl- d -aspartate receptor–dependent...
Although the molecular, cellular, and systems mechanisms required for initial memory processing have been intensively investigated, those underlying permanent storage remain elusive. We present neuroanatomical, pharmacological, genetic results demonstrating that anterior cingulate cortex plays a critical role in remote contextual fear conditioning. Imaging of activity-dependent genes shows is activated by this activation impaired null α-CaMKII mutation blocks memory. Accordingly, reversible...
Competition between neurons is necessary for refining neural circuits during development and may be important selecting the that participate in encoding memories adult brain. To examine neuronal competition memory formation, we conducted experiments with mice which manipulated function of CREB (adenosine 3',5'-monophosphate response element-binding protein) subsets neurons. Changes influenced probability individual lateral amygdala were recruited into a fear trace. Our results suggest...
The ability to learn and remember individuals is critical for the stability of social groups. Social recognition reflects mice identify conspecifics. assessed as a decrease in spontaneous investigation behaviors observed mouse reexposed familiar conspecific. Our results demonstrate that group-housed show memory juvenile when tested immediately, 30 min, 24 h, 3 days, 7 days after single 2-min-long interaction. Interestingly, chronic isolation disrupts long-term, but not 30-min, memory. Even...
Matrix metalloproteinases (MMPs) are extracellular proteases that have well recognized roles in cell signaling and remodeling many tissues. In the brain, their activation function customarily associated with injury or pathology. Here, we demonstrate a novel role for MMP-9 hippocampal synaptic physiology, plasticity, memory. protein levels proteolytic activity rapidly increased by stimuli induce late-phase long-term potentiation (L-LTP) area CA1. Such regulation requires NMDA receptors...
The authors describe how (a) the timing of hippocampal lesions and (b) behavioral-representational demands task affect requirement for hippocampus in contextual fear conditioning. Post- but not pretraining greatly reduced In contrast, abolished context discrimination, a procedure which mice are trained to discriminate between 2 similar chambers (shock vs. no-shock context). Whereas either contextual- or cue-based strategies can be used recognize an aversive context, discrimination contexts...