A5033576561- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Stroke Rehabilitation and Recovery
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Botulinum Toxin and Related Neurological Disorders
- S100 Proteins and Annexins
- RNA and protein synthesis mechanisms
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Advanced Neuroimaging Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Fractal and DNA sequence analysis
- Genomics and Rare Diseases
- Bangladesh Politics, Society, and Development
- Transcranial Magnetic Stimulation Studies
- Neurological Disorders and Treatments
- Educational Methods and Media Use
- Axon Guidance and Neuronal Signaling
- Technology-Enhanced Education Studies
- Genomics and Phylogenetic Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuropeptides and Animal Physiology
Jackson Laboratory
2023-2024
University of California, Los Angeles
2016-2023
Laguna State Polytechnic University
2022
Biocon (India)
2016
University College London
2014
Institute of Bioinformatics
2003-2005
Human Protein Reference Database (HPRD) is an object database that integrates a wealth of information relevant to the function human proteins in health and disease. Data pertaining thousands protein-protein interactions, posttranslational modifications, enzyme/substrate relationships, disease associations, tissue expression, subcellular localization were extracted from literature for nonredundant set 2750 proteins. Almost all was obtained manually by biologists who read interpreted >300,000...
Cis-regulatory elements (CREs) control gene expression, orchestrating tissue identity, developmental timing and stimulus responses, which collectively define the thousands of unique cell types in body
Stroke recovery research involves distinct biological and clinical targets compared to the study of acute stroke. Guidelines are proposed for pre-clinical modeling stroke alignment studies trials in recovery.
Stroke recovery research involves distinct biological and clinical targets compared to the study of acute stroke. Guidelines are proposed for pre-clinical modeling stroke alignment studies trials in recovery.
Ischemic injury to white matter tracts is increasingly recognized play a key role in age-related cognitive decline, vascular dementia, and Alzheimer's disease. Knowledge of the effects ischemic axonal on cortical neurons limited yet critical identifying molecular pathways that link neurodegeneration ischemia. Using mouse model subcortical coupled with retrograde neuronal tracing, we employed magnetic affinity cell sorting fluorescence-activated capture layer-specific performed...
Recently, chemokine receptor CC 5 (CCR5) was found to be a negative modulator of learning and memory. Its inhibition improved outcome after stroke traumatic brain injury (TBI). To better understand its role TBI establish therapeutic strategies, we investigated the effect reduced CCR5 signaling as neuroprotective strategy temporal changes expression in different cell types. silence expression, ccr5 short hairpin RNA (shRNA) or dsred shRNA (control) injected into cornu ammonis (CA) 1 CA3...
Stroke causes death of brain tissue leading to long-term deficits. Behavioral evidence from neurorehabilitative therapies suggest learning-induced neuroplasticity can lead beneficial outcomes. However, molecular and cellular mechanisms that link learning stroke recovery are unknown. We show in a mouse model stroke, which exhibits enhanced function due genetic perturbations memory genes, animals display activity-dependent transcriptional programs normally active during formation or storage...
Pharmacological inhibitors of epidermal growth factor receptor (ErbB1) attenuate the ability CNS myelin to inhibit axonal regeneration. However, it has been claimed that such effects are mediated by off-target interactions. We have tested role ErbB1 in regeneration culturing neurons from knockout mice presence various regeneration: myelin, chondroitin sulfate proteoglycans (CSPG), fibrinogen or polyinosinic:polycytidylic acid (poly I:C). confirmed was activated cultures cerebellar granule...
The gap that exists between reading and writing proficiency in English continues to grow. Moreover, the poor performance of students is alarming when it comes writing. kind approach, strategy, method has a big impact factor which would affect students’ performance. purpose this study determine significant difference Intensive approach terms word recognition, comprehension, speed. Also, Task- based sentence structure, vocabulary, cohesion, transition device. Consequently, intensive with...
Introduction: Small vessel ischemic strokes account for 25% of in the US. They often occur silently, increasing prevalence 5-10 fold and are progressive with new occurring adjacent to prior strokes. In this common form stroke, there is a local injury damaging axons white matter, distant neurons affected by leading cortical thinning connected cortex. This selective neuronal loss contributes minor stroke related cognitive dysfunction disability yet molecular response stroke-injured remains...