A5074233627- Acute Ischemic Stroke Management
- Adipokines, Inflammation, and Metabolic Diseases
- Cerebrovascular and Carotid Artery Diseases
- Dementia and Cognitive Impairment Research
- Stroke Rehabilitation and Recovery
- Blood properties and coagulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disorders and Treatments
- Cerebral Venous Sinus Thrombosis
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Lipoproteins and Cardiovascular Health
- Neurological and metabolic disorders
- Venous Thromboembolism Diagnosis and Management
- Cholinesterase and Neurodegenerative Diseases
- Apelin-related biomedical research
- Intraoperative Neuromonitoring and Anesthetic Effects
- Cardiovascular Disease and Adiposity
- Blood Coagulation and Thrombosis Mechanisms
- Posttraumatic Stress Disorder Research
- Traumatic Brain Injury and Neurovascular Disturbances
Tel Aviv Sourasky Medical Center
2016-2025
Tel Aviv University
2016-2025
Academic College of Tel Aviv-Yafo
2025
Shaare Zedek Medical Center
2021-2024
Hebrew University of Jerusalem
2024
Biomedical Research Institute
2022
Hospital de Sant Pau
2022
University College London
2022
Carmel Medical Center
2017
University of New Mexico
2016
Background:The percentage of working age people with mild stroke has risen. Evidence indicates that even impact cognition, executive functioning, and daily consequently affecting participation, quality life (QoL) return to work (RTW).Objectives:(1) Compare participation QoL between 3 months post-mild who RTW those did not; (2) To determine the correlates these variables participants post-stroke.Methods:We visited at home 163 survivors (117 men, 46 women) ranging from 50 89 years....
Inflammation may contribute to cognitive impairment after stroke. Inflammatory markers are associated with hippocampal atrophy. We tested whether of inflammation, erythrocyte sedimentation rate (ESR), and serum levels C-reactive protein reduced volume poor performance among stroke survivors.We analyzed 368 consecutive cases from our prospective study first-ever mild-moderate patients. MRI, tests, inflammatory were determined. Patients reevaluated 6 12 months the event.ESR remained unchanged...
Purpose: This study focused on the relationships between cognition, participation and quality of life (QoL) among first-ever mild ischemic stroke patients 3 months post-event. We hypothesized that significant correlations exist executive functions (EF), QoL participation; EF will significantly contribute to beyond demographics severity at from 6 post-stroke. Methods: A prospective cohort study, recruiting consecutive a large tertiary hospital. The inclusion criteria were first event, (NIHSS...
Background: White matter hyperintensities (WMH) were shown to predict cognitive decline following stroke or transient ischemic attack (TIA). However, WMH are only one among other radiological markers of cerebral small vessel disease (SVD). Objective: The aim this study was determine whether adding SVD improves prediction post-stroke performances. Methods: Consecutive first-ever TIA patients ( n = 266) from the Tel Aviv Acute Brain Stroke Cohort (TABASCO) enrolled. MRI scans performed within...
Type 2 diabetes mellitus (T2DM) is associated with diseases of the brain, kidney, and vasculature. However, relationship between T2DM, chronic kidney disease, brain alterations, cognitive function after stroke unknown. We aimed to evaluate inter-relationship impaired renal function, pathology on imaging, decline in a longitudinal poststroke cohort.The TABASCO (Tel Aviv acute cohort) prospective cohort stroke/transient ischemic attack survivors. The volume white matter integrity, lesions,...
Background:Stroke is a major cause of cognitive impairment and dementia. However, the underlying mechanisms beyond post-stroke (PSCI) are not fully explained to date. Objective:We studied contribution vascular pathology measures PSCI, separate from in conjunction with pathologic markers associated Alzheimer's disease (AD). Methods:Data 397 cognitively intact ischemic stroke patients were available. All underwent 3T MRI evaluated for white matter hyperintensity volume (WMHV) integrity,...
Cerebral microbleeds are associated with the risks of ischemic stroke and intracranial hemorrhage, causing clinical dilemmas for antithrombotic treatment decisions. We aimed to evaluate hemorrhage in patients atrial fibrillation treated vitamin K antagonists, direct oral anticoagulants, antiplatelets, combination therapy (i.e. concurrent anticoagulant antiplatelet).
Background Recent studies have demonstrated that even survivors of mild stroke experience residual damage, which persists and in fact increases subsequent years. About 45% victims remain with different levels disability. Identifying factors associated poststroke cognitive neurological decline could potentially yield more effective therapeutic opportunities. Aims hypothesis We hypothesize data based on biochemical, neuroimaging, genetic psychological measures can, aggregate, serve as better...
Background and purpose Stroke is a major cause of cognitive impairment dementia in adults, however the role ischemic lesions themselves, on top other risk factors known elderly, remains controversial. This study used structural equation modeling to determine respective impact new lesions' volume, preexisting white matter integrity post stroke state. Methods Consecutive first ever mild moderate or transient attack patients recruited into ongoing prospective TABASCO underwent magnetic...
Background Patients with chronic kidney disease are at increased risk of stroke and frequently have cerebral microbleeds. Whether such patients also encounter an recurrent has not been firmly established. We aimed to determine whether impaired function is associated the stroke, microbleed presence, distribution severity. Methods used pooled data from Microbleeds International Collaborate Network investigate associations function, defined as estimated glomerular filtration rate (eGFR) <60...
Early biomarkers for survival in an acute ischaemic stroke/transient attack might serve as a useful tool the clinician. Several studies have highlighted role of inflammatory early signal stroke prognosis.This study examines potential advantage using high-sensitivity interleukin-6 possible biomarker at stages identifying patients high risk 12-month mortality.Inflammatory and neurological scores were determined 250 following mild to moderate within 24 h hospital admission. Outcome data on...
Posttraumatic stress disorder (PTSD) can be triggered by life-threatening medical emergencies, such as stroke. Data suggest that up to 25% of stroke survivors will develop PTSD symptomatology, but little is known about predisposing factors. We sought examine whether neuroimaging measures and coping styles are related symptoms after stroke.Participants were first-ever, mild-moderate ischemic stroke, or transient attack from the TABASCO study (Tel Aviv Brain Acute Stroke Cohort). All...
To reveal the potential prognostic implications of admission inflammatory markers in patients with acute ischemic neurological events.Sixty an event who were examined within 24 h from appearance symptomatology. We determined high-sensitive C-reactive protein (hs-CRP) concentrations, erythrocyte sedimentation rate (ESR), fibrinogen concentrations and degree adhesiveness/aggregation.A significant correlation was noted between baseline hs-CRP ESR as well adhesiveness/aggregation outcome by...
Background and purpose Polymorphic paraoxonase ( PON 1) variants can variably prevent low‐ high‐density lipoprotein oxidation, but their role in provoking atherosclerosis remained unclear. We addressed this issue by profiling 1 polymorphisms enzymatic activities, assessing cerebral arteriosclerosis severity post‐stroke patients. Methods Carotid artery intima‐media‐thickness IMT ), white matter lesions WML serum ‐108 C / T , Q 192 R L 55 M polymorphisms, acetylcholinesterase (AChE) enzyme...
Patients with stroke are at risk for developing cognitive impairment. We tested whether the assessment of balance and gait can enhance prediction long-term outcome in survivors.Participants were patients first-ever, mild-moderate ischemic or transient attack from Tel Aviv Brain Acute Stroke Cohort (TABASCO) study, a large prospective cohort who underwent 3-T MRI followed ≥2 years using neurological, neuropsychological, mobility examinations 6, 12, 24 months after index event.Data available...
To evaluate the interrelationship among impaired renal function, brain pathology on imaging, and cognitive decline in a longitudinal poststroke cohort.The Tel Aviv Brain Acute Stroke Cohort study is prospective cohort of mild-moderate ischemic stroke/TIA survivors without dementia who underwent 3T MRI were cognitively assessed at admission for 24 months following stroke. Renal function was evaluated by creatinine clearance (CCl) estimation. The volumes lesions preexisting white matter...