A5059403151- Traumatic Brain Injury and Neurovascular Disturbances
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- Sepsis Diagnosis and Treatment
- Cardiovascular and exercise physiology
- Long-Term Effects of COVID-19
- Heart Rate Variability and Autonomic Control
- Intensive Care Unit Cognitive Disorders
- Transplantation: Methods and Outcomes
- Immune Response and Inflammation
- Optical Imaging and Spectroscopy Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Innovative Teaching Methods
- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Pulmonary Hypertension Research and Treatments
- Thermal Regulation in Medicine
- Acute Ischemic Stroke Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Innovations in Medical Education
- Exercise and Physiological Responses
- Neonatal Respiratory Health Research
University of Copenhagen
2014-2025
University of South Wales
2009-2025
Copenhagen University Hospital
2009-2025
Rigshospitalet
2016-2025
Bispebjerg Hospital
2016-2025
Naturalis Biodiversity Center
2024
UNSW Sydney
2023-2024
Capital Region of Denmark
2013-2024
University of Reading
2019
University College Cork
2019
According to animal studies, intake of probiotic bacteria may improve glucose homeostasis. We hypothesised that insulin sensitivity by attenuating systemic inflammation. Therefore, the effects oral supplementation with bacterium Lactobacillus acidophilus NCFM on and inflammatory response were investigated in subjects normal or impaired sensitivity. In a double-blinded, randomised fashion, forty-five males type 2 diabetes, tolerance enrolled allocated 4-week treatment course either L....
Background Many people recovering from coronavirus disease 2019 (COVID-19) experience prolonged symptoms, particularly breathlessness. We urgently need to identify safe and effective COVID-19 rehabilitative strategies. The aim of the current study was investigate potential role inspiratory muscle training (IMT). Methods 281 adults (age 46.6±12.2 years; 88% female) self-reported (9.0±4.2 months post-acute infection) were randomised 4:1 an 8-week IMT or a “usual care” waitlist control arm....
BackgroundSevere immunopathology may drive the deleterious manifestations that are observed in advanced stages of coronavirus disease 2019 (COVID-19) but poorly understood.ObjectiveOur aim was to phenotype leukocyte subpopulations and cytokine milieu lungs blood critically ill patients with COVID-19 acute respiratory distress syndrome (ARDS).MethodsWe consecutively included less than 72 hours after intubation following informed consent from their next kin. Bronchoalveolar lavage fluid...
Abstract We examined the extent to which apnoea‐induced extremes of oxygen demand/carbon dioxide production impact redox regulation cerebral bioenergetic function. Ten ultra‐elite apnoeists (six men and four women) performed two maximal dry apnoeas preceded by normoxic normoventilation, resulting in severe end‐apnoea hypoxaemic hypercapnia, hyperoxic hyperventilation designed ablate hypoxaemia, hyperoxaemic hypercapnia. Transcerebral exchange ascorbate radicals (by electron paramagnetic...
Patients who have undergone double lung transplantation (DLTx) are at increased risk of pulmonary thromboembolism (PTE). Although the presence clinically overt PTE can adversely affect short-term mortality, prognostic impact asymptomatic (silent) detected by routine imaging after DLTx is unclear. This study aimed to determine whether identified ventilation-perfusion single-photon emission computed tomography (V̇-Q̇ SPECT) 12 weeks post-DLTx associated with subsequent all-cause and...
This study examined whether hypoxia causes free radical-mediated disruption of the blood-brain barrier (BBB) and impaired cerebral oxidative metabolism this has any bearing on neurological symptoms ascribed to acute mountain sickness (AMS). Ten men provided internal jugular vein radial artery blood samples during normoxia 9-h passive exposure (12.9% O(2)). Cerebral flow was determined by Kety-Schmidt technique with net exchange calculated Fick principle. AMS headache were clinically...
Systemic inflammation is often associated with impaired glucose metabolism. We therefore studied the activation of inflammatory pathway intermediates that interfere uptake during systemic by applying a standardised stimulus in vivo. After ethical approval, informed consent and thorough physical examination, 10 patients type 2 diabetes participants normal tolerance (NGT) were given an intravenous bolus E. coli lipopolysaccharide (LPS) 0.3 ng/kg. Skeletal muscle biopsies plasma obtained at...
Abstract To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure of dipalmitoylphosphatidylcholine (DPPC). A total eleven patients with moderate-to-severe ARDS (CARDS) 15 healthy controls were included. CARDS had lower DPPC controls. Moreover, a principal component analysis was able separate patient groups into distinguishable subgroups. Our...
Abstract Background Plasma follistatin is elevated in patients with low‐grade inflammation and insulin resistance as observed polycystic ovary syndrome. In the present study, we evaluated plasma type 2 diabetes characterised by assessed acute effects of hyperglycemia, hyperinsulinemia LPS on follistatin. Methods Baseline inflammatory biomarkers were measured a cross‐sectional study that involved 95 103 matched controls. To determine effect hyperglycemia follistatin, hyperglycemic...
Abstract The mean flow index—usually referred to as Mx—has been used for assessing dynamic cerebral autoregulation (dCA) almost 30 years. However, concerns have arisen regarding methodological consistency, construct and criterion validity, test–retest reliability. Methodological nuances, such choice of input (cerebral perfusion pressure, invasive or non‐invasive arterial pressure), pre‐processing approach artefact handling, significantly influence index values, previous studies correlating...
There is limited knowledge on diffusing capacity in scoliosis patients. It remains to be determined if impaired pulmonary mostly influenced by reduced alveolar-capillary membrane (DM, CO), capillary blood volume (VC) or both. This study aims report findings from dual test gas for carbon monoxide and nitric oxide (DL, CO, NO) with quantification of corrected haemoglobin a five s breath-hold COc, 5s) NO, 5s), DM, CO VC. The included 57 patients idiopathic seen at our department 1972 1983, all...
Abstract Background Cardiopulmonary exercise testing (CPET) is usually considered the gold standard for assessing maximal oxygen consumption (V̇O 2max ), a health and performance marker in patients with chronic obstructive pulmonary disease (COPD). Despite widespread application of CPET, absolute relative test‐retest reliability CPET‐derived metrics remains unexamined. Objective To examine compare CPET derived individuals COPD healthy matched controls. Methods 12 age‐ sex‐matched controls...
High-intensity interval training (HIIT) has shown to improve exercise capacity, symptom burden, and quality of life in COPD patients, but it remains be investigated if HIIT can counteract limb muscle dysfunction. Therefore, we examined the impact a 12-week supervised protocol on oxygen conductance. Eight patients with mild moderate eight age-, sex- BMI-matched controls underwent intervention. Leg blood flow (Q̇ leg ) arterio-venous samples were collected at rest during active single-leg knee...
Abstract Purpose To investigate the efficacy of pulmonary blood volume (PBV) as a marker cardiac hyperemic response to adenosine during myocardial perfusion imaging (MPI). Methods Forty healthy subjects underwent four consecutive Rubidium‐82 rest/adenosine‐stress MPI: two sessions were conducted without any caffeine consumption (baseline), while remaining involved controlled (arm 1: 100 and 300 mg; arm 2: 200 400 mg). We evaluate ability stress‐to‐rest ratio PBV (PBV ratio) identify an...