A5079171698- Asthma and respiratory diseases
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Air Quality and Health Impacts
- COVID-19 and healthcare impacts
- Chronic Disease Management Strategies
- Noise Effects and Management
- Health Promotion and Cardiovascular Prevention
- Health disparities and outcomes
- Intensive Care Unit Cognitive Disorders
- Air Quality Monitoring and Forecasting
- Climate Change and Health Impacts
- COVID-19 epidemiological studies
- Inhalation and Respiratory Drug Delivery
- Global Health Care Issues
- Influenza Virus Research Studies
- School Health and Nursing Education
- Cardiovascular and exercise physiology
- IL-33, ST2, and ILC Pathways
- Vitamin D Research Studies
- Allergic Rhinitis and Sensitization
- Infection Control and Ventilation
Health Data Research UK
2021-2024
Swansea University
2015-2024
Swansea Bay University Health Board
2011-2024
University Hospitals Birmingham NHS Foundation Trust
2024
Queen Elizabeth Hospital
2024
Restore America's Estuaries
2023
NIHR Leicester Biomedical Research Centre
2021-2023
University Hospitals of Leicester NHS Trust
2023
University of Leicester
2021-2023
Glenfield Hospital
2023
There are a lack of reliable data on the epidemiology and associated burden costs asthma. We sought to provide first UK-wide estimates epidemiology, healthcare utilisation asthma.We obtained analysed asthma-relevant from 27 datasets: these comprised national health surveys for 2010-11, routine administrative, social care datasets 2011-12; 2011-12 were estimated in pounds sterling using economic modelling.The prevalence asthma depended definition source used. The UK lifetime patient-reported...
Background Many people recovering from coronavirus disease 2019 (COVID-19) experience prolonged symptoms, particularly breathlessness. We urgently need to identify safe and effective COVID-19 rehabilitative strategies. The aim of the current study was investigate potential role inspiratory muscle training (IMT). Methods 281 adults (age 46.6±12.2 years; 88% female) self-reported (9.0±4.2 months post-acute infection) were randomised 4:1 an 8-week IMT or a “usual care” waitlist control arm....
To determine the effect of population level implementation a test-and-treat approach to correction suboptimal vitamin D status (25-hydroxyvitamin (25(OH)D) <75 nmol/L) on risk all cause acute respiratory tract infection and covid 19.Phase 3 open label randomised controlled trial.United Kingdom.6200 people aged ≥16 years who were not taking supplements at baseline.Offer postal finger prick test blood 25(OH)D concentration with provision six month supply lower dose (800 IU/day, n=1550) or...
The COVID-19 pandemic's impact on people with asthma is poorly understood. We hypothesised that lockdown restrictions were associated reductions in severe exacerbations requiring emergency admissions and/or leading to death.Using data from Public Health Scotland and the Secure Anonymised Information Linkage Databank Wales, we compared weekly counts of deaths due over first 18 weeks 2020 national averages 2015-2019. modelled instigating these outcomes using interrupted time-series analysis....
The COVID-19 pandemic and ensuing national lockdowns have dramatically changed the healthcare landscape. pandemic's impact on people with chronic obstructive pulmonary disease (COPD) remains poorly understood. We hypothesised that UK-wide lockdown restrictions were associated reductions in severe COPD exacerbations. provide first level analyses of exacerbations resulting emergency hospital admissions and/or leading to death as well those recorded primary care or departments.
Risk factors for severe COVID-19 include older age, male sex, obesity, black or Asian ethnicity and underlying medical conditions. Whether these also influence susceptibility to developing is uncertain.We undertook a prospective, population-based cohort study (COVIDENCE UK) from 1 May 2020 5 February 2021. Baseline information on potential risk was captured by an online questionnaire. Monthly follow-up questionnaires incident COVID-19. We used logistic regression models estimate...
Prospective population-based studies investigating multiple determinants of pre-vaccination antibody responses to SARS-CoV-2 are lacking.
Antibody responses to SARS-CoV-2 vaccines vary for reasons that remain poorly understood. A range of sociodemographic, behavioural, clinical, pharmacologic and nutritional factors could explain these differences. To investigate this hypothesis, we tested presence combined IgG, IgA IgM (IgGAM) anti-Spike antibodies before after 2 doses ChAdOx1 nCoV-19 (ChAdOx1, AstraZeneca) or BNT162b2 (Pfizer-BioNTech) in UK adults participating a population-based longitudinal study who received their first...
To elicit the views of adolescents, with and without asthma, about exercise perceived benefits barriers to participation. The adolescent elicited would subsequently inform design a high-intensity intervention improve asthma control.Fifty-four adolescents (age 13.1 ± 0.9 years; 26 asthma) participated in twelve semi-structured group interviews. Questions were structured around knowledge, attitudes beliefs towards its impact on participation lifestyle. interviews transcribed verbatim,...
There is currently no consensus on approaches to defining asthma or assessing outcomes using electronic health record-derived data. We explored these in the recent literature and examined clarity of reporting. systematically searched for asthma-related articles published between January 1, 2014 December 31, 2015, extracted algorithms used identify patients assess severity, control exacerbations, how validity was justified. From 113 eligible articles, we found significant heterogeneity define...
Understanding of strategies to support individuals recovering from coronavirus disease 2019 (COVID-19) is limited. 'Long COVID' a multisystem characterised by range respiratory, gastrointestinal, cardiovascular, neurological, and musculoskeletal symptoms extending beyond 12 weeks. The aim this study was explore individuals' experiences COVID-19 provide better understanding the acute long-term impact on physical activity (PA). Individualised semi-structured interviews were conducted with 48...
Socioeconomic deprivation is known to be associated with worse outcomes in asthma, but there a lack of population-based evidence its impact across all stages patient care. We investigated the association socioeconomic asthma-related care and primary secondary death Wales.We constructed national cohort, identified from 76% (2.4 million) Welsh population, continuously treated asthma patients between 2013 2017 using anonymised, person-level, linked, routinely collected data Secure Anonymised...
Little is known about how demographic, behavioural, and vaccine-related factors affect risk of post-vaccination SARS-CoV-2 infection. We aimed to identify for infection after primary booster vaccinations. This prospective, population-based, UK study in adults (≥16 years) vaccinated against assessed breakthrough up February, 2022, participants who completed a vaccination course (ChAdOx1 nCoV-19 or BNT162b2) those received dose (BNT162b2 mRNA-1273). Cox regression models explored associations...
Abstract Microbial communities at the airway mucosal barrier are conserved and highly ordered, in likelihood reflecting co-evolution with human host factors. Freed of selection to digest nutrients, microbiome underpins cognate management immunity pathogen resistance. We show here initial results systematic culture whole-genome sequencing thoracic bacteria, identifying 52 novel species amongst 126 organisms that constitute 75% commensals typically present heathy individuals. Clinically...
This paper focuses on adverse drug reactions and the potential for introduction of nurse-led medication monitoring.The prevention patient harm caused by health-care organizations was accorded international priority over a decade ago, yet remain significant treatment burden to patients.This reviews literature summarize existing knowledge understand burdens associated with reactions.While epidemiological studies explore magnitude complex nature incidents in organizations, monitoring prescribed...
Asthma is now one of the most common long-term conditions in UK. It therefore important to develop a comprehensive appreciation healthcare and societal costs order inform decisions on care provision planning. We plan build our earlier estimates national prevalence from asthma by filling data gaps previously identified relation broadening field enquiry include costs. This work will provide first UK-wide asthma. In context for UK its member countries (ie, England, Northern Ireland, Scotland...
To assess the clinical effect of medication monitoring using West Wales Adverse Drug Reaction (ADR) Profile for Respiratory Medicine.Single-site parallel-arm pragmatic trial stratified randomisation.Nurse-led respiratory outpatient clinic in general hospital South Wales.54 patients with chronic disease receiving bronchodilators, corticosteroids or leukotriene receptor antagonists.Following initial observation usual nursing care, we allocated participants at random to receive follow up:...
Higher levels of cardiorespiratory fitness are associated with reduced asthma severity and increased quality life in those asthma. Therefore, the purpose this study was to evaluate effectiveness a 6-month high-intensity interval training (HIIT) intervention adolescents without asthma.A total 616 (334 boys; 13.0 ± 1.1 years, 1.57 0.10 m, 52.6 12.9 kg, mean SD), including 155 (78 boys), were recruited as part randomized controlled trial from 5 schools (4 control 1 intervention). The 221...
Background The imposition of restrictions on social mixing early in the COVID-19 pandemic was followed by a reduction asthma exacerbations multiple settings internationally. Temporal trends mixing, incident acute respiratory infections (ARI) and following relaxation have not yet been described. Methods We conducted population-based longitudinal study 2312 UK adults with between November 2020 April 2022. Details face covering use, ARI severe were collected via monthly online questionnaires....