A5101437318- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Immune Cell Function and Interaction
- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Nutrition and Health in Aging
- Studies on Chitinases and Chitosanases
- MicroRNA in disease regulation
- Cardiovascular and exercise physiology
- Circular RNAs in diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vagus Nerve Stimulation Research
- Diabetes and associated disorders
- Antioxidant Activity and Oxidative Stress
- Heart Rate Variability and Autonomic Control
- Sports injuries and prevention
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- S100 Proteins and Annexins
- Liver Disease and Transplantation
- Diet and metabolism studies
- Nerve injury and regeneration
- Diabetes Treatment and Management
- Clinical Nutrition and Gastroenterology
Rigshospitalet
2011-2024
Copenhagen University Hospital
2007-2024
Novo Nordisk (Denmark)
2023
University of Southern Denmark
2018
Frederiksberg Hospital
2018
University of Copenhagen
2007-2016
Universidad de Las Palmas de Gran Canaria
2012
Gentofte Hospital
2012
University of Thessaly
2010
Muscle specific miRNAs, myomiRs, have been shown to control muscle development in vitro and are differentially expressed at rest diabetic skeletal muscle. Therefore, we investigated the expression of these including miR-1, miR-133a, miR-133b miR-206 biopsies from vastus lateralis healthy young males (n = 10) relation a hyperinsulinaemic–euglycaemic clamp as well acute endurance exercise before after 12 weeks training. The subjects increased their capacity, VO2max (l min−1) by 17.4% (P <...
Skeletal muscle insulin resistance (IR) is considered a critical component of type II diabetes, yet to date IR has evaded characterization at the global gene expression level in humans. MicroRNAs (miRNAs) are fine-scale rheostats protein-coding product abundance. The relative importance and mode action miRNAs human complex diseases remains be fully elucidated. We produce map coding non-coding RNAs with aim identifying novel disease biomarkers. profiled >47,000 mRNA sequences >500 using...
MiRNAs are potent intracellular posttranscriptional regulators and also selectively secreted into the circulation in a cell-specific fashion. Global changes miRNA expression skeletal muscle response to endurance exercise training have been reported. Therefore, our aim was establish signature human plasma acute chronic by utilizing novel methodological approach. RNA isolated from collected young healthy men before after an bout following 12 weeks of training. (742 miRNAs) measurements were...
The cytokine interleukin-15 (IL-15) has been demonstrated to have anabolic effects in cell culture systems. We tested the hypothesis that IL-15 is predominantly expressed by type 2 skeletal muscle fibres, and resistance exercise regulates expression muscle. Triceps brachii, vastus lateralis quadriceps soleus biopsies were obtained from normally physically active, healthy, young male volunteers (n = 14), because these muscles are characterized having different fibre-type compositions. In...
OBJECTIVE Fibroblast growth factor-21 (FGF-21) is a potent metabolic regulator, which in animal models has been shown to improve glucose metabolism and insulin sensitivity. Recently, FGF-21 was be expressed secreted from murine muscle cells response stimulation. RESEARCH DESIGN AND METHODS We studied muscular expression plasma after acute stimulation young healthy men during hyperinsulinemic- euglycemic clamp. Furthermore, we investigated systemic levels humans with or without resistance...
IL-15 decreases lipid deposition in preadipocytes and the mass of white adipose tissue rats, indicating that may take part regulating this tissue. is expressed human skeletal muscle be a source plasma way regulate mass.The relation between mRNA expression, IL-15, was studied 199 humans divided into four groups on basis obesity type 2 diabetes. Furthermore, using DNA electrotransfer model, we assessed effect overexpression mice.In humans, multiple regression analysis showed negative...
Background: There is a considerable commercial market, especially within the sports community, claiming need for antioxidant supplementation. One argument supplementation in that physical exercise associated with increased reactive oxygen and nitrogen species (RONS) production, which may cause cell damage. However, RONS production also activate redox-sensitive signaling pathways transcription factors, subsequently, promote training adaptation. Purpose: Our aim was to investigate effects of...
FSP27 (fat-specific protein 27) is a member of the cell death-inducing DNA fragmentation factor-alpha-like effector (CIDE) family. Although Cidea and Cideb were initially characterized as activators apoptosis, recent studies have demonstrated important metabolic roles for these proteins. In this study, we investigated function another family, (Cidec), in apoptosis adipocyte metabolism. overexpression sufficient to increase 293T 3T3-L1 cells, more physiological levels expression stimulate...
Follistatin is a member of the TGF-β super family and inhibits action myostatin to regulate skeletal muscle growth. The regulation follistatin during physical exercise unclear but may be important because activity major intervention prevent age-related sarcopenia. First, healthy subjects performed either bicycle or one-legged knee extensor exercise. Arterial-venous differences were assessed experiment. Next, mice 1 h swimming, expression was examined in various tissues using quantitative...
YKL-40 is produced by macrophages, and plasma elevated in patients with diseases characterized inflammation. In the present study, was examined relation to obesity, inflammation, type 2 diabetes.Plasma adipose tissue mRNA levels were investigated 199 subjects who divided into four groups depending on presence or absence of diabetes obesity. addition, healthy during a hyperglycemic clamp, which glucose level kept at 15 mmol/l for 3 h, hyperinsulinemic-euglycemic clamp.Patients had higher...
The two inflammatory molecules, S100A8 and S100A9, form a heterodimer, calprotectin. Plasma calprotectin levels are elevated in various disorders. We hypothesized that plasma would be increased subjects with low-grade systemic inflammation i.e. either obese or type 2 diabetes.Plasma skeletal muscle mRNA were measured cohort consisting of 199 divided into four groups depending on presence absence diabetes (T2D), obesity. There was significant interaction between obesity T2D (p = 0.012)....
Mutations in PINK1 cause the mitochondrial-related neurodegenerative disease Parkinson's. Here we investigate whether obesity, type 2 diabetes, or inactivity alters transcription from locus. We utilized a cDNA-array and quantitative real-time PCR for gene expression analysis of muscle healthy volunteers following physical inactivity, adipose tissue nonobese obese subjects with normal glucose tolerance diabetes. Functional studies were performed utilizing RNA interference cell culture models....
Objective Myostatin is a secreted growth factor expressed in skeletal muscle tissue, which negatively regulates mass. Recent animal studies suggest role for myostatin insulin resistance. We evaluated the possible metabolic of patients with type 2 diabetes and healthy controls. Design 76 92 control subjects were included study. They matched age, gender BMI. Plasma samples biopsies from vastus lateralis obtained to assess plasma expression muscle. Results Patients had higher fasting glucose...
Aim: It was recently reported that serum retinol‐binding protein (RBP), also known as 4 (RBP4), positively associated with systemic insulin resistance. We hypothesized an imbalance between RBP and retinol might be the underlying cause for this association. Methods: studied ratio in 233 humans divided into groups depending on normal glucose tolerance (NGT), impaired (IGT), type 2 diabetes (T2DM) presence or absence of obesity. Results: Plasma levels were lower patients T2DM than individuals...
While production of reactive oxygen and nitrogen species (RONS) is associated with some the beneficial adaptations to regular physical exercise, it not established whether RONS play a role in improved insulin-stimulated glucose uptake skeletal muscle obtained by endurance training. To assess effect antioxidant supplementation during training on uptake, 21 young healthy (age 29 ± 1 y, BMI 25 3 kg/m(2)) men were randomly assigned either an [AO; 500 mg vitamin C 400 IU E (α-tocopherol) daily]...
Vitamin C and E supplementation has been shown to attenuate the acute exercise-induced increase in plasma interleukin-6 (IL-6) concentration. Here, we studied effect of antioxidant vitamins on regulation IL-6 expression muscle circulation response exercise before after high-intensity endurance training. Twenty-one young healthy men were allocated into either a vitamin (VT; E, n = 11) or placebo (PL, 10) group. A 1-h bicycling trial at 65% maximal power output was performed 12 wk progressive...
Abstract Background Plasma follistatin is elevated in patients with low‐grade inflammation and insulin resistance as observed polycystic ovary syndrome. In the present study, we evaluated plasma type 2 diabetes characterised by assessed acute effects of hyperglycemia, hyperinsulinemia LPS on follistatin. Methods Baseline inflammatory biomarkers were measured a cross‐sectional study that involved 95 103 matched controls. To determine effect hyperglycemia follistatin, hyperglycemic...